Advances in communication and computer technologies have revolutionized the way health information is gathered, disseminated, and used by healthcare providers, patients, citizens, and mass media, leading to the emergence of a new field and new language captured in the term "e-health." As exciting as these technologic changes are, they have led to sometimes overly optimistic prognostications about what e-health can do to improve the health of patients and the public and the quality of care available from providers. While conceding the significant advantages bestowed by the technologic developments and their adoption into the healthcare system, we contend that without careful and systematic research and policy, e-health may work primarily to the advantage of individuals and communities with greater resources and healthcare systems that serve them. This could have the effect of deepening disparities in health status between population subgroups.There are some significant challenges that must be addressed by the research community to assure that advances in e-health will help eliminate, not exacerbate, health disparities. These include identifying and clearly articulating specific disparity issues that affect different domains of e-health, enhancing survey sampling and measurement in e-health research to better understand and address disparities, and critically examining e-health and communicationrelated policies that may affect health disparities.