The Role of Curcumin in Modulating Colonic Microbiota During Colitis and Colon Cancer Prevention

McFadden, Rita Marie T.; Larmonier, Claire B.; Shehab, Kareem W.; Midura-Kiela, Monica T.; Ramalingam, Rajalakshmy; Harrison, Christy A.; Besselsen, David G.; Chase, John; Caporaso, J. Gregory; Jobin, Christian; Ghishan, Fayez K.; Kiela, Pawel R.

doi:10.1097/mib.0000000000000522

Cited by 186 publications

(116 citation statements)

References 68 publications

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“…For some of these molecules, it is clear that they can be incorporated into the skin . However, for others, it remains possible that their mode of action may be via gut microbial metabolism , or by altering the gut microbiota .…”

Section: How Gut and Skin Can Impact On One Another – Principle Pathwaysmentioning

confidence: 99%

The gut‐skin axis in health and disease: A paradigm with therapeutic implications

et al. 2016

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As crucial interface organs gut and skin have much in common. Therefore it is unsurprising that several gut pathologies have skin co-morbidities. Nevertheless, the reason for this remains ill explored, and neither mainstream gastroenterology nor dermatology research have systematically investigated the 'gut-skin axis'. Here, in reviewing the field, we propose several mechanistic levels on which gut and skin may interact under physiological and pathological circumstances. We focus on the gut microbiota, with its huge metabolic capacity, and the role of dietary components as potential principle actors along the gut-skin axis. We suggest that metabolites from either the diet or the microbiota are skin accessible. After defining open key questions around the nature of these metabolites, how they are sensed, and which cutaneous changes they can induce, we propose that understanding of these pathways will lead to novel therapeutic strategies based on targeting one organ to improve the health of the other.

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Section: How Gut and Skin Can Impact On One Another – Principle Pathwaysmentioning

confidence: 99%

The gut‐skin axis in health and disease: A paradigm with therapeutic implications

et al. 2016

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“…Moreover, McFaden et al [45] used a well-documented model of a study on the development of colitis-associated CRC. This study was performed using specific pathogen-free wild-type (WT) 129/SvEv mice and germ-free interleukin (IL)10−/− mice.…”

Section: In Vivo Studies: the Effect Of Curcumin On Colorectal Cancermentioning

confidence: 99%

Curcumin and Colorectal Cancer: From Basic to Clinical Evidences

Pricci

Girardi

Giorgio

et al. 2020

IJMS

160

100

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Curcumin diffuses through cell membranes into the endoplasmic reticulum, mitochondria, and nucleus, where it exerts actions, as an antioxidant property. Therefore, its use has been advocated for chemopreventive, antimetastatic, and anti-angiogenic purposes. We conducted a literature review to summarize studies investigating the relationship between curcumin and colorectal cancer (CRC). In vitro studies, performed on human colon cancer cell lines, showed that curcumin inhibited cellular growth through cycle arrest at the G2/M and G1 phases, as well as stimulated apoptosis by interacting with multiple molecular targets. In vivo studies have been performed in inflammatory and genetic CRC animal models with a chemopreventive effect. To improve curcumin bioavailability, it has been associated with small particles that increase its absorption when orally administered with excellent results on both inflammation and carcinogenesis. Curcumin has been used, moreover, as a component of dietetic formulations for CRC chemoprevention. These combinations showed in vitro and in vivo anticarcinogenetic properties in inflammation-related and genetic CRC. A synergic effect was suggested using an individual constituent dosage, which was lower than that experimentally used “in vivo” for single components. In conclusion, curcumin falls within the category of plant origin substances able to prevent CRC in animals. This property offers promising expectations in humans.

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“…Dietary interventions, such as a curcumin-supplemented diet increased survival and entirely eliminated tumor burden in a mouse model of colitis-associated colorectal cancer. The beneficial effect of curcumin on tumorigenesis was associated with the maintenance of a more diverse colonic microbial ecology (Mcfadden et al, 2015). Furthermore, dietary intervention with polyphenol extracts modulate the human gut microbiota toward a more healthy profile increasing the relative abundance of bifidobacteria and lactobacilli (Marchesi et al, 2015).…”

Section: Toward the Clinical Applications Of Host-microbiome Interactmentioning

confidence: 99%

Host-Microbiome Interaction and Cancer: Potential Application in Precision Medicine

et al. 2016

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It has been experimentally shown that host-microbial interaction plays a major role in shaping the wellness or disease of the human body. Microorganisms coexisting in human tissues provide a variety of benefits that contribute to proper functional activity in the host through the modulation of fundamental processes such as signal transduction, immunity and metabolism. The unbalance of this microbial profile, or dysbiosis, has been correlated with the genesis and evolution of complex diseases such as cancer. Although this latter disease has been thoroughly studied using different high-throughput (HT) technologies, its heterogeneous nature makes its understanding and proper treatment in patients a remaining challenge in clinical settings. Notably, given the outstanding role of host-microbiome interactions, the ecological interactions with microorganisms have become a new significant aspect in the systems that can contribute to the diagnosis and potential treatment of solid cancers. As a part of expanding precision medicine in the area of cancer research, efforts aimed at effective treatments for various kinds of cancer based on the knowledge of genetics, biology of the disease and host-microbiome interactions might improve the prediction of disease risk and implement potential microbiota-directed therapeutics. In this review, we present the state of the art of sequencing and metabolome technologies, computational methods and schemes in systems biology that have addressed recent breakthroughs of uncovering relationships or associations between microorganisms and cancer. Together, microbiome studies extend the horizon of new personalized treatments against cancer from the perspective of precision medicine through a synergistic strategy integrating clinical knowledge, HT data, bioinformatics, and systems biology.

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The Role of Curcumin in Modulating Colonic Microbiota During Colitis and Colon Cancer Prevention

Cited by 186 publications

References 68 publications

The gut‐skin axis in health and disease: A paradigm with therapeutic implications

The gut‐skin axis in health and disease: A paradigm with therapeutic implications

Curcumin and Colorectal Cancer: From Basic to Clinical Evidences

Host-Microbiome Interaction and Cancer: Potential Application in Precision Medicine

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