The role of curcumin in aging and senescence: Molecular mechanisms

Zia, Aliabbas; Farkhondeh, Tahereh; Pourbagher‐Shahri, Ali Mohammad; Samarghandian, Saeed

doi:10.1016/j.biopha.2020.111119

Cited by 219 publications

(118 citation statements)

References 139 publications

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“…Oral administration of curcumin protects Swiss albino mice against rotenone-induced dysfunction in the mitochondrial respiratory chain and conserves the mitochondrial enzyme complex, which is reflected in the improvement of motor behavior of the animals after three weeks of curcumin administration [ 114 ]. In addition, curcumin beneficially modulates mitochondrial malfunction and immature senescence [ 115 , 116 ]. It efficiently improves mitochondrial enzyme complex activities in the rotenone-induced PD model [ 114 ].…”

Section: Curcumin As a Potential Neuroprotective Agentmentioning

confidence: 99%

Neuroprotective Activities of Curcumin in Parkinson’s Disease: A Review of the Literature

Nebrisi

2021

IJMS

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Parkinson’s disease (PD) is a slowly progressive multisystem disorder affecting dopaminergic neurons of the substantia nigra pars compacta (SNpc), which is characterized by a decrease of dopamine (DA) in their striatal terminals. Treatment of PD with levodopa or DA receptor agonists replaces the function of depleted DA in the striatum. Prolonged treatment with these agents often has variable therapeutic effects and leads to the development of undesirable dyskinesia. Consequently, a crucial unmet demand in the management of Parkinson’s disease is the discovery of new approaches that could slow down, stop, or reverse the process of neurodegeneration. Novel potential treatments involving natural substances with neuroprotective activities are being developed. Curcumin is a polyphenolic compound isolated from the rhizomes of Curcuma longa (turmeric). It has been demonstrated to have potent anti-inflammatory, antioxidant, free radical scavenging, mitochondrial protecting, and iron-chelating effects, and is considered a promising therapeutic and nutraceutical agent for the treatment of PD. However, molecular and cellular mechanisms that mediate the pharmacological actions of curcumin remain largely unknown. Stimulation of nicotinic receptors and, more precisely, selective α7 nicotinic acetylcholine receptors (α7-nAChR), have been found to play a major modulatory role in the immune system via the “cholinergic anti-inflammatory pathway”. Recently, α7-nAChR has been proposed to be a potential therapeutic approach in PD. In this review, the detailed mechanisms of the neuroprotective activities of curcumin as a potential therapeutic agent to help Parkinson’s patients are being discussed and elaborated on in detail.

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Section: Curcumin As a Potential Neuroprotective Agentmentioning

confidence: 99%

Neuroprotective Activities of Curcumin in Parkinson’s Disease: A Review of the Literature

Nebrisi

2021

IJMS

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“…Curcumin belongs to the class of hormetic agents that stabilize Nrf2 and enhance expression of HO-1. Curcumin triggers Nrf2 pathway, which has a pivotal role in activating antioxidant enzymes, such as thioredoxin reductase, Hsp70, sirtuins [ 49 , 50 , 51 , 52 ]. Furthermore, another study finding reported that curcumin increased the activity of several antioxidant enzymes including protein thiol, non-protein thiol, GPx, and SOD in dogs fed with curcumin on day 30 compared with control dogs.…”

Section: Antioxidant Role Of Curcuminmentioning

confidence: 99%

Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain

et al. 2021

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The nutrients and their potential benefits are a new field of study in modern medicine for their positive impact on health. Curcumin, the yellow polyphenolic compound extracted from Curcuma longa species, is widely used in traditional Ayurvedic medicine to prevent and contrast many diseases, considering its antioxidant, immunomodulatory, anti-inflammatory, anti-microbial, cardio-protective, nephron-protective, hepato-protective, anti-neoplastic, and anti-rheumatic proprieties. In recent years, the investigations of curcumin have been focused on its application to aging and age-associated diseases. Aging is a physiological process in which there is a decreasing of cellular function due to internal or external stimuli. Oxidative stress is one of the most important causes of aging and age-related diseases. Moreover, many age-related disorders such as cancer, neuroinflammation, and infections are due to a low-grade chronic systemic inflammation. Curcumin acting on different proteins is able to contrast both oxidative stress than inflammation. In the brain, curcumin is able to modulate inflammation induced by microglia. Finally in brain tumors curcumin is able to reduce tumor growth by inhibition of telomerase activity. This review emphasizes the anti-aging role of curcumin focusing on its mechanism to counteract aging in the brain. Moreover, new formulations to increase the bioavailability of curcumin are discussed.

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“…Finally, the antioxidant effect of curcumin is mainly correlated to KEAP1-NRF2-ARE pathway (42,43). Curcumin induces NRF2 upregulation, mainly by binding to Kelch-like ECH-associated protein 1 (KEAP1), resulting in oxidative stress reduction (31,44,45). Nonetheless, it has been reported that curcumin exerts a neuroprotective effect by reverting the increased expression of heat shock protein 90 (Hsp90) in models of neurotoxicity (46).…”

Section: Molecular Targets Of Curcuminmentioning

confidence: 99%

The pharmacological basis of the curcumin nutraceutical uses: an update

Canistro¹,

Chiavaroli²,

Cicia³

et al. 2021

Pharm Adv

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Curcumin is the major phytoconstituent found in the rhizomes of Curcuma longa L. Preparations derived from the rhizome of the plant, referred as turmeric, have been used for centuries in the traditional Indian system of medicine. The recent literature has shown curcumin as one of the most interesting pleiotropic nutraceuticals capable of interacting with different molecular targets involved in chronic diseases. The present review summarizes and critically discusses the very recent literature published between 2018 and 2021. We focused on the preclinical pharmacological actions of curcumin in relation to its possible clinical application in several pathophysiological states and disturbances including inflammation and pain, as well as metabolic, cardiovascular, dermatological, and central nervous system diseases. The most relevant molecular targets of curcumin, such as transcription factors, pro-inflammatory mediators, enzymes, and protein kinase as well as pharmacokinetics in humans are also reviewed.

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The role of curcumin in aging and senescence: Molecular mechanisms

Cited by 219 publications

References 139 publications

Neuroprotective Activities of Curcumin in Parkinson’s Disease: A Review of the Literature

Neuroprotective Activities of Curcumin in Parkinson’s Disease: A Review of the Literature

Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain

The pharmacological basis of the curcumin nutraceutical uses: an update

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