The Role of Cyclic Amp in the Interaction of Glucagon and Insulin in the Control of Liver Metabolism*

Exton, John H.; Lewis, Stephen B.; Ho, Ren-Jye; Robison, G. Alan; Park, C. R.

doi:10.1111/j.1749-6632.1971.tb45239.x

Cited by 196 publications

(45 citation statements)

References 20 publications

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“…It is possible that tolbutamide, especially with prolonged incubation time, influences cell membrane transport processes; data from erythrocytes appear compatible with this idea (24). Although the efflux of nucleotide seems to be a sensitive reflection of the time-integrated cyclic AMP stimulation in many experimental systems (25) including islets, (9,14), it is obvious that this is not true under all experimental circumstances.…”

Section: Discussionmentioning

confidence: 99%

Interacting Effects of Sulfonylureas and Glucose on Cyclic AMP Metabolism and Insulin Release in Pancreatic Islets of the Rat

Grill¹,

Cerasi²

1978

J. Clin. Invest.

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Section: Discussionmentioning

confidence: 99%

Interacting Effects of Sulfonylureas and Glucose on Cyclic AMP Metabolism and Insulin Release in Pancreatic Islets of the Rat

Grill¹,

Cerasi²

1978

J. Clin. Invest.

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“…This system is present in hepatocytes and in cells of the proximal tubule, mostly in the pars recta (39,40). As a result, cAMP generated in hepatocytes may be secreted in the blood (24)(25)(26)(27) and taken up and secreted by proximal tubule cells (29,36,41).…”

Section: Discussionmentioning

confidence: 99%

“…Intravenous administration of glucagon is known to induce a marked and prompt rise in plasma cAMP, due to a rapid exit of this nucleotide from hepatocytes (24)(25)(26)(27)(28). cAMP is excreted by the kidney as a result of both filtration and secretion.…”

Section: Introductionmentioning

confidence: 99%

Cyclic AMP is a hepatorenal link influencing natriuresis and contributing to glucagon-induced hyperfiltration in rats.

Ahloulay¹,

Déchaux²,

Hassler³

et al. 1996

J. Clin. Invest.

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The effects of glucagon (G) on proximal tubule reabsorption (PTR) and GFR seem to depend on a prior action of this hormone on the liver resulting in the liberation of a mediator and/or of a compound derived from amino acid metabolism. This study investigates in anesthetized rats the possible contribution of cAMP and urea, alone and in combination with a low dose of G, on phosphate excretion (known to depend mostly on PTR) and GFR. After a 60-min control period, cAMP (5 nmol/min ϫ 100 grams of body weight [BW]) or urea (2.5 mol/min ϫ 100 grams BW) was infused intravenously for 200 min with or without G (1.2 ng/min ϫ 100 grams BW, a physiological dose which, alone, does not influence PTR or GFR). cAMP increased markedly the excretion of phosphate and sodium ( ϩ 303 and ϩ 221%, respectively, P Ͻ 0.01 for each) but did not alter GFR. Coinfusion of cAMP and G induced the same tubular effects but also induced a 20% rise in GFR ( P Ͻ 0.05). Infusion of urea, with or without G, did not induce significant effects on PTR or GFR. After G infusion at increasing doses, the increase in fractional excretion of phosphate was correlated with a simultaneous rise in plasma cAMP concentration and reached a maximum for doubling of plasma cAMP. These results suggest that cAMP, normally released by the liver into the blood under the action of G, ( a ) is probably an essential hepatorenal link regulating the intensity of PTR, and ( b ) contributes, in conjunction with specific effects of G on the nephron, to the regulation of GFR. ( J. Clin. Invest. 1996. 98: 2251-2258.)

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“…The role of cAMP in the metabolic actions of several hormones has been demonstrated in perfused preparations by Park et al (19)(20)(21)(22). In those experiments, catecholamines sti mulated hepatic gluconeogenesis and glycogenolysis by raising the intracellular level of cAMP.…”

Section: Discussionmentioning

confidence: 90%

Adrenergic Receptors in Rat Liver

Hagino

Nakashima

1974

Japanese Journal of Pharmacology

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The Role of Cyclic Amp in the Interaction of Glucagon and Insulin in the Control of Liver Metabolism*

Cited by 196 publications

References 20 publications

Interacting Effects of Sulfonylureas and Glucose on Cyclic AMP Metabolism and Insulin Release in Pancreatic Islets of the Rat

Interacting Effects of Sulfonylureas and Glucose on Cyclic AMP Metabolism and Insulin Release in Pancreatic Islets of the Rat

Cyclic AMP is a hepatorenal link influencing natriuresis and contributing to glucagon-induced hyperfiltration in rats.

Adrenergic Receptors in Rat Liver

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