The Role of Cyclooxygenase Enzymes in the Effects of Losartan and Lisinopril on the Contractions of Rat Thoracic Aorta

Özatik, Fikriye Yasemin; Kaygisiz, Bilgin; Erol, Kevser

doi:10.5152/eurasianjmed.2017.16254

Cited by 3 publications

(3 citation statements)

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“…COX is the rate-limiting enzyme for the synthesis of prostaglandins and the names of its three isozymes are COX-1, COX-2 and COX-3 ( 103 ). COX-1 is COX-1 is constitutively expressed in the majority of cell types regulating vascular homeostasis.…”

Section: Shared Genetic Polymorphisms and Biological Mechanismsmentioning

confidence: 99%

Genetic factors involved in the co‑occurrence of endometriosis with ankylosing spondylitis (Review)

et al. 2023

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Previous research has revealed an association between endometriosis and various autoimmune diseases, while recent data suggest, for the first time, an association between endometriosis and the risk of developing ankylosing spondylitis (AS). AS, the prototype of spondyloarthritides diseases, is a systemic, chronic, immune-mediated inflammatory arthritis, which primarily affects the spine and sacroiliac joints, as well as the axial skeleton with or without extraspinal manifestations. AS is of polygenic inheritance and numerous immunologically relevant genes contribute to its development. Endometriosis is an enigmatic, relatively common, benign, estrogen-dependent, heterogeneous gynecological disease, influenced by multiple genetic, epigenetic and environmental factors. It is characterized by the growth of endometrial tissue occurring in sites other than the uterine cavity, most commonly in the pelvic cavity, including the ovaries and the uterosacral ligaments, affecting up to 10% of the female population of childbearing age, causing pain and infertility. The present review discusses whether a partially shared genetic background may explain the co-occurrence of these disorders, as well as potential similarities regarding the underlying pathogenetic mechanisms and specific molecular and cellular pathways.

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Section: Shared Genetic Polymorphisms and Biological Mechanismsmentioning

confidence: 99%

Genetic factors involved in the co‑occurrence of endometriosis with ankylosing spondylitis (Review)

et al. 2023

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“…Dipyrone (Metamizole ® ) inhibits Cox-3 more effectively than Cox-1 and Cox-2 and this effect is concentration dependent in that high levels (IC50 >1000 mM) inhibit all three isoforms, moderate levels (IC50: 350 mM) inhibt Cox-1 and Cox-3 and low levels (IC50: 52 mM) inhibit only Cox-3 [120 reviewed in 129,130]. It was suggested "that Cox inhibition achieved with dipyrone may be responsible for the augmentation of the smooth-muscle relaxing effects of the angiotensin-converting enzymes (ACEs) inhibitor losartan or lisinopril" while the combination of dipyrone with losartan inhibited phenylephrine (Phe), potassium chloride (KCl), and angiotensin II (Ang II) induced contractions compared to combined dipyrone with lisinopril inhibiting Phe and Ang II-induced contractions [130].…”

Section: Eicosanoidsmentioning

confidence: 99%

Eicosanoids in carcinogenesis

Brücher

Jamall

2019

4open

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Inflammation is the body's reaction to pathogenic (biological or chemical) stimuli and covers a burgeoning list of compounds and pathways that act in concert to maintain the health of the organism. Eicosanoids and related fatty acid derivatives can be formed from arachidonic acid and other polyenoic fatty acids via the cyclooxygenase and lipoxygenase pathways generating a variety of pro- and anti-inflammatory mediators, such as prostaglandins, leukotrienes, lipoxins, resolvins and others. The cytochrome P450 pathway leads to the formation of hydroxy fatty acids, such as 20-hydroxyeicosatetraenoic acid, and epoxy eicosanoids. Free radical reactions induced by reactive oxygen and/or nitrogen free radical species lead to oxygenated lipids such as isoprostanes or isolevuglandins which also exhibit pro-inflammatory activities. Eicosanoids and their metabolites play fundamental endocrine, autocrine and paracrine roles in both physiological and pathological signaling in various diseases. These molecules induce various unsaturated fatty acid dependent signaling pathways that influence crosstalk, alter cell–cell interactions, and result in a wide spectrum of cellular dysfunctions including those of the tissue microenvironment. Although the complete role of eicosanoids, including that of the recently elucidated anti-inflammatory specialized pro-resolving lipid mediators (SPMs), e.g. lipoxins, resolvins, protectins and maresins, is not completely understood, the result of unremitting chronic inflammation is fostering early stages of carcinogenesis. Chronic inflammation facilitates the transition from a normal cell to a cancerous one. The disruption of homeostasis across a wide, but identifiable, swath of diverse molecular pathways creates a micromilieu which constitutes an early and necessary step in the 6-step sequence of carcinogenesis for the vast majority of cancers, termed “sporadic cancers”.

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“…Cyclooxygenase (COX) functions as the rate-limiting enzyme for the prostaglandin (PG) synthesis and has three isozymes, namely COX-1, COX-2 and COX-3 (Ozatik et al, 2017). As an inducing enzyme, COX-2 shows low or even no expression in the majority of tissues under normal physiological status, and expresses lowly only in limited tissues, like the central nervous system and kidney (Eslami et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Connection of COX‐2 variants to ankylosing spondylitis susceptibility

Liu

Wang

Zhang

2021

Journal Cellular Physiology

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This study aimed to explore the associations of COX‐2 polymorphisms rs5275, rs20417, and rs2745557 with the susceptibility to ankylosing spondylitis among Chinese Han people. Polymerase chain reaction‐restriction fragment length polymorphism (PCR/RFLP) was adopted for genotyping COX‐2 polymorphisms rs5275, rs20417, and rs2745557 among 109 AS patients and 122 healthy controls. Genotype distribution in the control group was examined for these three polymorphisms to test whether it conformed to Hardy‐Weinberg equilibrium (HWE) expectation. A χ2‐test was employed to compare genotype and allele frequencies between the two groups. Besides this, logistic regression analyses were also performed to adjust age and gender. A p less than .05 represented a significant level. Genotype distribution of our studied polymorphisms showed fine conformity to HWE in the controls. An increasing effect on AS risk was detected for the polymorphism rs5275 under GG versus AA contrast (crude: OR, 3.040; 95% CI, 1.015–9.104), and the adjustment for age and gender did not change such a relationship (adjusted OR, 3.307; 95% CI, 1.065–10.268). After adjusting age and gender, both polymorphisms of rs20417 and rs2745557 demonstrated a negative relationship with the disease susceptibility. The GC genotype and C allele of rs20417 reduced the disease risk to 0.248 (adjusted: 95% CI, 0.089–0.692) and 0.269 (95% CI, 0.098–0.733), respectively, while the AA genotype and A allele of the latter to 0.413 (adjusted: 95% CI, 0.191–0.893) and 0.676 (adjusted: 95% CI, 0.466–0.981), respectively. Among Chinese Han people, COX‐2 polymorphism rs5275 may contribute to increased risk of developing AS, while the polymorphisms rs20417 and rs2745557 may offer protection against disease incidence.

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The Role of Cyclooxygenase Enzymes in the Effects of Losartan and Lisinopril on the Contractions of Rat Thoracic Aorta

Cited by 3 publications

References 34 publications

Genetic factors involved in the co‑occurrence of endometriosis with ankylosing spondylitis (Review)

Genetic factors involved in the co‑occurrence of endometriosis with ankylosing spondylitis (Review)

Eicosanoids in carcinogenesis

Connection of COX‐2 variants to ankylosing spondylitis susceptibility

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