The Role of Cytocin Imbalance in the Development
Of Man Infertility

Бабинец, Л. С.; Migenko, Bogdan O.; Borovyk, I. O.; Halabitska, I. M.; Lobanets, Nataliia V.; Onyskiv, Orest O.

doi:10.36740/wlek202003123

Cited by 11 publications

(2 citation statements)

References 20 publications

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“…In the present study, IL-17A levels on days 3, 7, and 42 after LPS injection increased and could have been correlated with sperm damage. This result is consistent with the study conducted by Babinets et al [ 30 ], who showed that increased Il-17A levels were correlated with male infertility. A study on urinary tract infections (UTIs) caused by uropathogenic E. coli reported that IL-17 was a key mediator of the innate immune response to UTIs [ 13 ].…”

Section: Discussionsupporting

confidence: 93%

The effect of lipopolysaccharide from uropathogenic Escherichia coli on the immune system, testis tissue, and spermatozoa of BALB/c mice

Khanmohammad

Khalili

Sadeh

et al. 2021

Clin Exp Reprod Med

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Objective: Uropathogenic Escherichia coli is known to cause urinary tract infections, and the endotoxin (lipopolysaccharide [LPS]) of this bacterium may cause deficiencies of sperm quality and morphology. In the present study, the effects of LPS on mouse sperm were studied, and the levels of interleukin (IL)-17A and possible changes in testis tissue were evaluated.Methods: LPS of uropathogenic E. coli was extracted using the methanol-chloroform method, followed confirmation using sodium dodecyl sulfate-polyacrylamide electrophoresis. Purified LPS (100 µg/kg) or phosphate-buffered saline was injected intraperitoneally into BALB/c mice for 7 days consecutively in the test and control groups, Mice were sacrificed on days 3, 7, and 42 after the first injection. Blood was tested for levels of IL-17A using the enzyme-linked immunosorbent assay method. Testis tissue and sperm were collected from each mouse and were studied according to standard protocols. Results: The mean sperm count and motility significantly decreased (p=0.03) at 3, 7, and 42 days after the injections. The level of IL-17A in the test groups increased, but not significantly (p=0.8, p=0.11, and p=0.15, respectively). Microscopic studies showed no obvious changes in the morphology of the testis tissue; however, significant changes were observed in the cellular parenchyma on day 42. Conclusion: LPS can stimulate the immune system to produce pro-inflammatory cytokines, resulting in an immune response in the testis and ultimately leading to deficiency in sperm parameters and testis tissue damage. In addition, the presence of LPS could significantly impair sperm parameters, as shown by the finding of decreased motility.

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Section: Discussionsupporting

confidence: 93%

The effect of lipopolysaccharide from uropathogenic Escherichia coli on the immune system, testis tissue, and spermatozoa of BALB/c mice

Khanmohammad

Khalili

Sadeh

et al. 2021

Clin Exp Reprod Med

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“…In our study, seminal plasma IL-17 level in infertile patients was significantly higher in comparison with healthy controls, which sheds light on its role in the pathogenesis of male infertility. In agreement with our results, Babinets et al [11] found that the concentration of IL-17 increases in infertile men with chronic urethral prostatitis and they concluded that it may be a good biomarker of chronic inflammation of the urogenital tract.…”

Section: Discussionsupporting

confidence: 93%

Evaluation of seminal plasma interleukin 17 in infertile males

et al. 2021

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Background: Interleukin-17 (IL-17) is a proinflammatory cytokine that is involved in the pathogenesis of several autoimmune and inflammatory diseases. Inflammation of the testis and male-reproductive tracts may lead to male infertility. Objective: To assess seminal plasma IL-17 in infertile male patients and to evaluate its relation to the different seminal parameters. Patients and Methods: Fifty male patients with primary infertility were included in addition to 20 age-matched healthy fertile males as controls. The semen was analyzed half an hour after the ejaculation according to the WHO criteria, including sperm count, morphology, motility, viability, and leukocytecount. Seminal plasma levels of IL-17 were measured using the ELISA technique. Results:The mean seminal plasma level of IL-17 was significantly higher in infertile patients (2.42±2.43ng/l) than in controls (0.28±0.66ng/l). Also, the mean seminal plasma IL-17 level was significantly higher in patients with abnormal progressive sperm motility (4.0±2.73ng/l) than patients with normal progressive sperm motility (2.07±2.26ng/l). Conclusion: IL-17 may play an important role in the pathogenesis of male infertility associated with inflammation and infection of the testis and male genital tracts and it could be a good therapeutic target in those cases, but further studies are needed to determine the exact pathogenic role of IL-17 in male infertility.

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Male Fertility in Spondyloarthritis: from Clinical Issues to Cytokines Milieu. A Narrative Review

Scriffignano,

Perrotta,

Lubrano

2024

Curr Rheumatol Rep

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Purposeof Review Male fertility is an emergent issue that should be considered in clinical practice, when dealing with chronic inflammatory diseases in young men. As it is known, the chronic inflammation is the main pathophysiologic mechanism in some rheumatological conditions such as spondyloarthritis (SpA), Ankylosing Spondylitis (AS) and Psoriatic Arthritis (PsA). Therefore, it is paramount to be aware if these diseases could impair male fertility, both due to the inflammation or to the treatments needed: we reviewed the literature on the most relevant and recent evidence on male fertility in patients affected by SpA, AS and PsA. Recent Findings Rheumatological inflammatory diseases (included SpA, AS and PsA) could impair the family planning in man life, especially when diagnosed at young age. Moreover, focusing on sperm quality, it seems that a link between sperm quality impairment and a higher disease activity exist. Focusing on therapies, Tumor Necrosis Factor inhibitors showed a safety profile on human male fertility in clinical studies. Recently, a prospective study and two double-blind placebo-controlled trials assessed the impact of methotrexate and Filgotinib on semen parameters, respectively, showing a safety profile of these drugs on human semen quality. However, there are no clinical data on the impact of Interleukin (IL)17 inhibitors(i), IL12-23i and IL23i. Summary Concerning male fertility in SpA, AS and PsA, an unmet clinical need is still present and new studies are needed to understand the association between these diseases and male fertility, and the implication of the therapies used for these diseases. This narrative review provides an overview of the available data on male fertility in patients affected by SpA, AS and PsA.

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The Role of Cytocin Imbalance in the Development Of Man Infertility

Cited by 11 publications

References 20 publications

The effect of lipopolysaccharide from uropathogenic Escherichia coli on the immune system, testis tissue, and spermatozoa of BALB/c mice

The effect of lipopolysaccharide from uropathogenic Escherichia coli on the immune system, testis tissue, and spermatozoa of BALB/c mice

Evaluation of seminal plasma interleukin 17 in infertile males

Male Fertility in Spondyloarthritis: from Clinical Issues to Cytokines Milieu. A Narrative Review

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