The Role of DACT Family Members in Tumorigenesis and Tumor Progression

Abstract

Disheveled-associated antagonist of β-catenin (DACT), which ubiquitously expressed in human tissue, is critical for regulating cell proliferation and several developmental processes in different cellular contexts. In addition, DACT is essential for some other cellular processes, such as cell apoptosis, migration and differentiation. Given the importance of DACT in these cellular processes, many scientists are gradually interested in studying the role of DACT in tumorigenesis and cancer progression. This review article focuses on the latest research regarding the essential functions and potential DACT mechanisms in the occurrence and progression of tumors. Our study indicates that DACT may act as a tumor biomarker for cancer diagnosis and prognosis, as well as a promising therapeutic target in cancers.

Multiomics integration reveals the effect of Orexin A on glioblastoma

“…Although some advances have been realized in the treatment of GBM, such as the application of temozolomide and bevacizumab, patients with GBM still encounter poor treatment effect and drug resistance. (Tan et al, 2017;Jiapaer et al, 2018;Kickingereder et al, 2020;Reardon et al, 2020;Nayak et al, 2021;Tesileanu et al, 2022;Zeng et al, 2022). Tumor therapeutic field (TTF) therapy has also been approved by the FDA for recurrent (2011) and newly diagnosed (2015) GBM, but the lack of generalizability of data from previous studies has prevented TTF from being widely used.…”