The role of damage- and pathogen-associated molecular patterns in inflammation-mediated vulnerability of atherosclerotic plaques

Abstract

https://mc06.manuscriptcentral.com/cjpp-pubs

IL-17A in Psoriasis and Beyond: Cardiovascular and Metabolic Implications

“…Of note, the same mediators are also known to be linked to endothelial dysfunction and vascular calcification in other inflammatory diseases such as autoimmune diseases, inflammatory bowel syndromes, and rheumatoid arthritis. Cytokines and mediators including TNF-α, IL-1β, IL-6, and IFNγ, along with MMP, are also responsible, upon stimulation, of the destabilization of atherosclerotic plaques, leading to ischemic events (96).…”

Synthetic CpG oligonucleotides as potential modulators of neutrophil survival in PAMP-associated inhibition of apoptosis

“…At the same time, pro‐inflammatory mediator production by PAMP‐stimulated host cells underlies a variety of disorders. It is now widely accepted that the initiation and progression of atherosclerotic lesions involves both sterile and infectious chronic inflammatory responses . Although the molecular mechanisms underlying the pathogenesis of rheumatoid arthritis are not fully understood, there is increasing evidence that activation of PRRs, as well as infections by many microorganisms, might play an important role in the maintenance of inflammation in rheumatoid arthritis.…”

Association of serum neuron‐specific enolase and bilirubin levels with cerebral dysfunction and prognosis in large‐artery atherosclerotic strokes

“…4 Accumulating evidence has shown that arterial walls thickening, the formation of atherosclerotic plaques and vascular stenosis were significant risk factors for ischemic cerebrovascular disease. 6 Although most subtypes of ischemic stroke share similar risk factors, they have different etiologies, 7 so it is important to investigate the pathogenesis and prognostic factors for LAA-type stroke compare with other type of stroke. 6 Although most subtypes of ischemic stroke share similar risk factors, they have different etiologies, 7 so it is important to investigate the pathogenesis and prognostic factors for LAA-type stroke compare with other type of stroke.…”