The role of declining ataxia-telangiectasia-mutated (ATM) function in oocyte aging
Reiko Suzuki,
Xiujuan Tan,
Katarzyna J. Szymanska
et al.
Abstract:Despite the advances in the understanding of reproductive physiology, the mechanisms underlying ovarian aging are still not deciphered. Recent research found an association between impaired ATM-mediated DNA double-strand break (DSB) repair mechanisms and oocyte aging. However, direct evidence connecting ATM-mediated pathway function decline and impaired oocyte quality is lacking. The objective of this study was to determine the role of ATM-mediated DNA DSB repair in the maintenance of oocyte quality in a mouse… Show more
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