The role of depressive symptoms and symptom dimensions in actigraphy-assessed sleep, circadian rhythm, and physical activity

Difrancesco, Sonia; Penninx, Brenda W. J. H.; Riese, Harriëtte; Giltay, Erik J.; Lamers, Femke

doi:10.1017/s0033291720004870

Cited by 14 publications

(12 citation statements)

References 37 publications

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“…They found a unidirectional association between motor activity and subjective mood level and a bidirectional association between motor activity and subjective energy level and sleep duration. Difrancesco et al ( 14 ) obtained similar results, with a negative correlation of gross motor activity (GMA) and sleep parameters with depressive symptoms. Tonon et al ( 15 ) demonstrate the reliability of using an actigraphic strategy for evaluating the intensity of depression.…”

Section: Resultsmentioning

confidence: 70%

Digital phenotype of mood disorders: A conceptual and critical review

et al. 2022

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BackgroundMood disorders are commonly diagnosed and staged using clinical features that rely merely on subjective data. The concept of digital phenotyping is based on the idea that collecting real-time markers of human behavior allows us to determine the digital signature of a pathology. This strategy assumes that behaviors are quantifiable from data extracted and analyzed through digital sensors, wearable devices, or smartphones. That concept could bring a shift in the diagnosis of mood disorders, introducing for the first time additional examinations on psychiatric routine care.ObjectiveThe main objective of this review was to propose a conceptual and critical review of the literature regarding the theoretical and technical principles of the digital phenotypes applied to mood disorders.MethodsWe conducted a review of the literature by updating a previous article and querying the PubMed database between February 2017 and November 2021 on titles with relevant keywords regarding digital phenotyping, mood disorders and artificial intelligence.ResultsOut of 884 articles included for evaluation, 45 articles were taken into account and classified by data source (multimodal, actigraphy, ECG, smartphone use, voice analysis, or body temperature). For depressive episodes, the main finding is a decrease in terms of functional and biological parameters [decrease in activities and walking, decrease in the number of calls and SMS messages, decrease in temperature and heart rate variability (HRV)], while the manic phase produces the reverse phenomenon (increase in activities, number of calls and HRV).ConclusionThe various studies presented support the potential interest in digital phenotyping to computerize the clinical characteristics of mood disorders.

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Section: Resultsmentioning

confidence: 70%

Digital phenotype of mood disorders: A conceptual and critical review

et al. 2022

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“…Findings on physical activity are controversial. While some studies report preliminary evidence for lower physical activity ( Difrancesco et al, 2019 ) and a negative correlation between depressive symptom severity and physical activity in depressed individuals ( Difrancesco et al, 2021 ), another study found no such effects ( Lorenz et al, 2019 ).…”

Section: Circadian Regulation Of Behaviour and Cognitive Functioningmentioning

confidence: 99%

It’s About Time: The Circadian Network as Time-Keeper for Cognitive Functioning, Locomotor Activity and Mental Health

et al. 2022

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A variety of organisms including mammals have evolved a 24h, self-sustained timekeeping machinery known as the circadian clock (biological clock), which enables to anticipate, respond, and adapt to environmental influences such as the daily light and dark cycles. Proper functioning of the clock plays a pivotal role in the temporal regulation of a wide range of cellular, physiological, and behavioural processes. The disruption of circadian rhythms was found to be associated with the onset and progression of several pathologies including sleep and mental disorders, cancer, and neurodegeneration. Thus, the role of the circadian clock in health and disease, and its clinical applications, have gained increasing attention, but the exact mechanisms underlying temporal regulation require further work and the integration of evidence from different research fields. In this review, we address the current knowledge regarding the functioning of molecular circuits as generators of circadian rhythms and the essential role of circadian synchrony in a healthy organism. In particular, we discuss the role of circadian regulation in the context of behaviour and cognitive functioning, delineating how the loss of this tight interplay is linked to pathological development with a focus on mental disorders and neurodegeneration. We further describe emerging new aspects on the link between the circadian clock and physical exercise-induced cognitive functioning, and its current usage as circadian activator with a positive impact in delaying the progression of certain pathologies including neurodegeneration and brain-related disorders. Finally, we discuss recent epidemiological evidence pointing to an important role of the circadian clock in mental health.

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“…Disordered sleep also has a signi cant impact on cognitive ability, as has been shown in studies with children, with the elderly, and with victims of traumatic brain injury, among others (9). Reduced sleep quality can also increase emotional distress, mood swings, behavioral problems, and de cits in cognitive performance (10)(11)(12). The cumulative effect of disrupted sleep can lead to severe impairments in daytime wakefulness and cognitive functioning.…”

Section: Introductionmentioning

confidence: 96%

Underrecognized Sleep Disorders Across Rare Diseases: Real-world Insights From a Patient and Caregiver Summit

Picone¹,

Naujokas²,

Gorman³

et al. 2021

Preprint

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Background: Disorders of sleep-wake stability have a negative impact on patient and caregiver quality of life. There is evidence that sleep disorders and their sequelae may be an underrecognized burden for people living with rare diseases. Given that the sleep-wake cycle is regulated via the hypothalamus, people with neurological disorders may be particularly affected. To collect real-world insights into the impact of sleep disturbances and excessive daytime sleepiness (EDS) on people with rare disorders, Harmony Biosciences organized a Summit on Sleep Disruption. The attendees were from seven patient advocacy groups, each representing a rare neurological disorder reporting sleep disturbances, specifically EDS: Angelman syndrome, idiopathic hypersomnia, Kleine-Levin syndrome, myotonic dystrophy, narcolepsy, Prader-Willi syndrome, and Smith-Magenis syndrome. One person represented COMBINEDBrain, a patient advocacy consortium representing 25 rare, genetic neurological disorders. Results: The overwhelming response was that disordered sleep, particularly EDS, is a major health problem within their populations that they feel is not adequately diagnosed or treated. Participants felt that burdens associated with sleep disturbances were underrecognized as a treatable medical issue and were not effectively addressed by health care providers. Participants noted the following unmet needs: patient and physician education on sleep disturbance, effective medications approved for these disease populations, and medically acceptable patient-centered devices to measure sleep parameters. Participants described impacts of disordered sleep and EDS on behavior and school performance, describing impaired wakefulness as an interference with normal daytime functioning. Participants also revealed tremendous burdens on the caregivers and family members who live with people experiencing sleep-wake instability. Conclusions: These results provide real-world insights that disordered sleep including EDS and subsequent impaired daytime functioning are major burdens in these rare disease communities. Furthermore, these burdens are underrecognized for caregivers and, for some rare diseases, among the patients themselves. Participants identified gaps in knowledge and treatment of sleep disorders and resolved to continue the dialog to find ways to raise awareness of disordered sleep and reduce burdens in these patient populations.

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The role of depressive symptoms and symptom dimensions in actigraphy-assessed sleep, circadian rhythm, and physical activity

Cited by 14 publications

References 37 publications

Digital phenotype of mood disorders: A conceptual and critical review

Digital phenotype of mood disorders: A conceptual and critical review

It’s About Time: The Circadian Network as Time-Keeper for Cognitive Functioning, Locomotor Activity and Mental Health

Underrecognized Sleep Disorders Across Rare Diseases: Real-world Insights From a Patient and Caregiver Summit

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