The role of diet in prostate cancer

Abstract

This is a one-to-one, age- and race-matched case-control study involving 55 histologically confirmed black prostate cancer patients and 55 controls who were seen at three major hospitals in Washington, DC from 1982 to 1984. Personal interviews were conducted to obtain the number of times food items of specified serving size were consumed per week by cases and controls; the subjects were grouped according to the age periods 30-49 and 50 years and older. We then calculated the average daily consumption of each of 18 nutrients per 1,000 calories. There was a significant negative association between linoleic acid (p less than 0.04) for the 50 years and older group, thiamin (p less than 0.05) for those 30-49 years old, riboflavin (p less than 0.03) for the 50 and older group, and iron (p less than 0.05) for those 30-49 years old. The results of this study suggest that the intake of thiamin and iron (in subjects 30-49 years old), linoleic acid and riboflavin (in subjects 50 years and over) could be protective because control subjects consumed more of these nutrients than did the cases.

A Prospective Study of Polyunsaturated Fatty Acid Levels in Blood and Prostate Cancer Risk

“…However, results from epidemiologic studies do not support the notion that 18:2n-6 intake increases prostate cancer risk (16,17). Most investigations have yielded null findings (5,16,(18)(19)(20)(21)(22)(23)(24)(25), with fewer studies reporting statistically significant positive (26,27) or inverse associations (4,28,29) between 18:2n-6 and prostate cancer risk. In previous studies where tissue levels of 18:2n-6 have been related to prostate cancer risk, those where tissues were collected after cancer diagnosis have reported positive associations with prostate cancer (26,27), whereas prospective studies have yielded inverse associations (4,5,19), albeit not always statistically significant.…”

Linking vitamin B1 with cancer cell metabolism

“…However, like so many other nutritional correlations with cancer incidence, the dietary intake of thiamine and cancer risk has provided conflicting results. Using nutritional questionnaires and a calculated average daily intake level, patients with prostate cancer consume less thiamine than those without cancer suggesting a negative association with cancer risk [37]. A 2008 study examined the relationship between the intake of B vitamins and incidence of breast, endometrial, ovarian, colorectal, and lung cancer in women [38].…”

Diet and prostatic cancer: A case‐control study in northern Italy

“…High levels of consumption of fat and animal proteins increased the risk of prostatic cancer significantly in most (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23) but not all studies (24)(25)(26)(27). Indirect evidence on the unfavorable role of excess fat and/or energy intake in prostatic carcinogenesis derives from the finding, in some epidemiological studies (13,15,28,29), that prostatic cancer is more frequent in overweight men.…”