The role of dietary fatty acid intake in inflammatory gene expression: a critical review

Rocha, Daniela Mayumi Usuda Prado; Bressan, Josefina; Hermsdorff, Helen Hermana Miranda

doi:10.1590/1516-3180.2016.008607072016

Cited by 89 publications

(46 citation statements)

References 77 publications

(150 reference statements)

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“…A high SFA intake has been associated with proinflammatory response and gene regulation involved in inflammatory pathways, such as TNF-a, in adipose tissue. 59,60 In contrast, we observed a reduction in the amount of adiponectin messenger RNA (mRNA) expression, with increasing adipocyte size when VCO was combined with HFD. These results evidence that VCO when associated with HFD induces low-grade inflammation in adipose tissue, altering cytokines production, increasing proinflammatory and reducing anti-inflammatory markers.…”

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confidence: 73%

Virgin Coconut Oil Associated with High-Fat Diet Induces Metabolic Dysfunctions, Adipose Inflammation, and Hepatic Lipid Accumulation

Ströher

Oliveira

Martinez-Oliveira

et al. 2020

Journal of Medicinal Food

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Obesity reaches an epidemic level worldwide, and this condition is associated with chronic low-grade inflammation and secondary comorbidities, largely driven by global changes in lifestyle and diet. Various dietary approaches are proposed for the obesity treatment and its associated metabolic disorders. Good taste, antioxidant functions, and vitamins have been attributed to virgin coconut oil (VCO). However, VCO contains a large amount of saturated fatty acids, and the consumption of this fat is associated with a number of secondary diseases. We evaluate the effects of VCO supplementation on biochemical, inflammatory, and oxidative stress parameters in rats fed with high-fat diet (HFD). After feeding with HFD for 12 weeks, the animals were supplemented with VCO for 30 days. HFD+VCO group increased in diet intake, weight gain, low-density lipoprotein cholesterol level, and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. These findings were accompanied by increased in hepatic lipid profile and fat deposition in the liver. Adipocyte hypertrophy was observed in the HFD+VCO group, which was associated with elevated expression of tumor necrosis factor alpha (TNF-a) in adipose tissue. These results revealed that VCO associated with HFD induced important metabolic alterations, adipose inflammation, and hepatic lipid accumulation in rats.

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confidence: 73%

Virgin Coconut Oil Associated with High-Fat Diet Induces Metabolic Dysfunctions, Adipose Inflammation, and Hepatic Lipid Accumulation

Ströher

Oliveira

Martinez-Oliveira

et al. 2020

Journal of Medicinal Food

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“…Hydrogenated fats, ingredients commonly used in ultra-processed foods, have been identified as responsible for an increase in the inflammatory state of the body, via stimulating the activity of prostaglandin E2 and inhibiting anti-inflammatory agents, such as prostaglandins E1 and E3. It is known that prostaglandin E2 acts at birth by inducing uterine contraction 36,37 , which would favor early labor, prematurity and consequently low birth weight in neonates.…”

Section: Discussionmentioning

confidence: 99%

Relationship between food consumption of pregnant women and birth weight of newborns

2020

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The aim of this study was to investigate the relationship between food consumption of 99 pregnant women aged 16-44 years who gave birth at a maternity hospital in Rio de Janeiro and newborn birth weight. Maternal consumption of unprocessed or minimally processed and ultra-processed foods was evaluated through the Food Consumption Markers Form. For ultra-processed foods, most pregnant women regularly consumed sweets (73.7%), soft drinks (71.7%), sausages (65.7%), salted crackers (63.6%) and fried foods (55.6%). Among unprocessed or minimally processed foods, most pregnant women consumed beans (85.9%) and milk or yogurt (60.6%), while less than half consumed fruits (44.4%), raw vegetables (28.3%) and cooked vegetables (27.3%) regularly. Among newborns, 13.5% presented low birth weight. There was a significant relationship between consumption of sausages (p= 0.02) and sweets (p= 0.04) by pregnant women and low birth weight of newborns. Maternal consumption of sausages increased the odds of newborn low birth weight (OR 1.46, 95% CI 1.02-2.10).

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“…The type of FA stored in AT, besides adipocyte fat overload, critically affects tissue functions. FA can directly or indirectly modify immune and inflammatory responses by several mechanisms, acting on cell surface and intracellular receptors that control cell signaling and gene expression [12,13] . Recent studies have indicated that dietary FA quality rather than quantity has major implications in meta-inflammation development.…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies have indicated that dietary FA quality rather than quantity has major implications in meta-inflammation development. In fact, FA exhibit either pro-or anti-inflammatory activity depending on their chemical structure [11,13] . In general, long-chain SFA have been associated with inflammation while short-chain FA show anti-inflammatory effects [14] .…”

Section: Introductionmentioning

confidence: 99%

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Dietary fatty acids and adipose tissue inflammation at the crossroad between obesity and colorectal cancer

Conti¹,

Cornò²,

Scazzocchio³

et al. 2019

JCMT

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Excess adiposity, a worldwide-growing pathological condition, is now recognized as a main risk factor for most chronic diseases including colorectal cancer (CRC). Obese subjects show an increased cancer incidence with obesity representing an important indicator of survival, prognosis, recurrence and response to therapy. A lowgrade chronic inflammation of metabolically active tissues including the adipose tissue (AT), defined as metainflammation, is a main feature of obesity. Fatty acids (FA), the main AT components, are important modulators of inflammation, and the type of FA stored in AT critically affects tissue functions. Their profile within AT mirrors FA dietary intake but also depends on a metabolic control. Obesity, changes in the habitual diet, weight loss or pathological conditions like CRC influence FA profile of AT pointing to these molecules as important actors in AT dysfunction and meta-inflammation, that characterize metabolic diseases and may favor cancer development. Worth of note, diet is receiving growing attention as a main determinant in cancer prevention due to its capacity to modulate immune response and inflammation. Alterations in the balance between different families of FA may contribute to generate a pro-inflammatory profile with deleterious effects on metabolic and immune homeostasis at both local and systemic levels. This review focuses on FA as regulators of human AT inflammation discussing the role of obesity-, diet-, and weight loss-associated changes in FA profile in this process. The relevance of FA composition of AT in linking diet, obesity and CRC will be also reviewed.

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The role of dietary fatty acid intake in inflammatory gene expression: a critical review

Cited by 89 publications

References 77 publications

Virgin Coconut Oil Associated with High-Fat Diet Induces Metabolic Dysfunctions, Adipose Inflammation, and Hepatic Lipid Accumulation

Virgin Coconut Oil Associated with High-Fat Diet Induces Metabolic Dysfunctions, Adipose Inflammation, and Hepatic Lipid Accumulation

Relationship between food consumption of pregnant women and birth weight of newborns

Dietary fatty acids and adipose tissue inflammation at the crossroad between obesity and colorectal cancer

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