The role of dietary polyphenols in the management of erectile dysfunction–Mechanisms of action

Eleazu, Chinedum; Obianuju, Nwite; Eleazu, Kate; Kalu, Winner

doi:10.1016/j.biopha.2017.01.125

Cited by 28 publications

(29 citation statements)

References 66 publications

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“…Based on the pivotal roles of polyphenol on the suppression of MAO-B [32] and its role on penile erection via eNOS [33] together with the improved testicular functions [34] induced by polyphenol rich substance, we did suggest that the sexual enhancing effect of A. occidentale leaves extract might be associated with polyphenolic compounds content in the extract. However, this still required further investigation.…”

Section: Discussionmentioning

confidence: 99%

Sexual Enhancing Effect of Anacardium occidentale in Stress-Exposed Rats by Improving Dopaminergic and Testicular Functions

Prabsattroo

Somsapt

Sritragool

et al. 2018

BioMed Research International

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In this study, we aimed to assess the effect and possible underlying mechanism of Anacardium occidentale leaves extract on male sexual behaviors in stress-exposed rats. Male Wistar rats were orally given A. occidentale extract at doses of 25, 100, and 200 mg/kg BW before 12-hour-immobilization exposure for 14 days. Sexual behaviors, serum testosterone and corticosterone levels, TH-positive cells density in nucleus accumbens (NAc) and ventral tegmental area (VTA), MAO-B activity in NAc and medial preoptic area (MPOA), testis histology together with phosphodiesterase type-5 ( PDE-5) activity, and endothelial nitric oxide synthase (eNOS) expression in penis were evaluated after treatment. All doses of extract improved male sexual behaviors, suppressed MAO-B in NAc, enhanced TH-positive cells density in NAc, suppressed PDE-5 in penis, and enhanced interstitial cell of Leydig. The increase of serum testosterone, TH-positive cells density in VTA, eNOS expression in penis, and the decreased serum corticosterone were observed at some doses. Therefore, the sexual enhancing effect of extract occurred mainly via the improved dopaminergic and testicular functions. PDE-5 suppression in penis also played the role especially in the increased intromission behavior. Therefore, A. occidentale leaves extract is the potential protective agent against sexual dysfunction. However, further researches are necessary.

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Section: Discussionmentioning

confidence: 99%

Sexual Enhancing Effect of Anacardium occidentale in Stress-Exposed Rats by Improving Dopaminergic and Testicular Functions

Prabsattroo

Somsapt

Sritragool

et al. 2018

BioMed Research International

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“…Polyphenols could be classified into five groups namely: (a) phenolic acids, (b) stilbenes, (c) lignans (d) flavonoids, and (e) curcuminoids (Eleazu and Eleazu, 2015; Ly et al, 2015; Eleazu et al, 2017). …”

Section: Methodsmentioning

confidence: 99%

“…They are also abundant in fruits like citruses and apples; in certain vegetables such as shallot, tomatoes, potatoes, and bean sprouts and in various plants and spices (licorice, cardamom). Xanthohumol is the main prenylated chalcone, predominately found in beer (Mojzer et al, 2016; Eleazu et al, 2017). …”

Section: Methodsmentioning

confidence: 99%

“…Curcuminoids represent another class of polyphenols; a typical example being curcumin which is found in Curcuma longa (Eleazu et al, 2017). …”

Section: Methodsmentioning

confidence: 99%

“…Natural polyphenols have increasingly gained public interest in recent times. This could be attributed to the emerging evidence that suggests their roles in the prevention of various disease that implicate free radicals/reactive oxygen species (ROS; Scalbert et al, 2005; Eleazu et al, 2013a,b, 2017). However, the role of these polyphenols in the management of BPH and their mechanisms of action are yet to be reported.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Management of Benign Prostatic Hyperplasia: Could Dietary Polyphenols Be an Alternative to Existing Therapies?

Eleazu¹,

Eleazu

Kalu

2017

Front. Pharmacol.

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The incidence of benign prostatic hyperplasia (BPH) is gradually on the increase. While conventional drugs such as the α1-adrenergic receptor antagonists and 5α-reductase inhibitors have been found to be useful in the treatment of BPH, the adverse side effects associated with their usage, have led to increased search for alternative means of managing this disease. Furthermore, although surgery has also been suggested to be a sure method, the cost and risks associated with it excludes it as a routine treatment. Dietary polyphenols have gained public interest in recent times due to their roles in the prevention of various diseases that implicate free radicals/reactive oxygen species. However, their roles in the management of BPH have not been explored. Hence, this review on their prospects in the management of BPH and their mechanisms of action. Literature search was carried out in several electronic data bases such as PubMed, Google Scholar, Medline, Agora, and Hinari from1970 to 2017 to identify the current status of knowledge on this concept. The findings from these data bases suggest that while dietary polyphenols may not replace the need for the existing therapies in the management of BPH, they hold promise in BPH management which could be explored by researchers working in this field.

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Effects of Talinum triangulare leaf flavonoid extract on streptozotocin‐induced hyperglycemia and associated complications in rats

Oluba

Adebiyi

Dada

et al. 2018

Food Science & Nutrition

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Talinum triangulare leaf flavonoid extract (TTFE) was evaluated for its effects on streptozotocin‐hyperglycemia and associated complications especially as it relates to dyslipidemia, lipid peroxidation, and renal dysfunction in rats. Two normoglycemic rat groups designated: control (administered distilled water) and control + TTFE (administered 10 mg/kg b.w. TTFE) and two streptozotocin‐induced (STZ) diabetic rat groups designated: STZ‐control (administered distilled water) and STZ + TTFE (administered 10 mg/kg TTFE). The treatment was given orally once daily for 21 consecutive days. Body weight and insulin concentration showed significant improvement while blood glucose, uric acid, creatinine, and total bilirubin concentrations were significantly reduced in diabetic rats administered TTFE compared to diabetic untreated rats. Furthermore, triglycerides, total cholesterol, LDL‐cholesterol, and malondialdehyde concentrations were significantly lowered in diabetic rats administered TTFE compared with diabetic untreated rats. Key enzymes involved in carbohydrate breakdown and cholesterol synthesis, α‐amylase and 3‐hydroxy‐3‐methylglutaryl‐CoA (HMG‐CoA) reductase, respectively, were significantly inhibited in TTFE‐treated diabetic rats compared to diabetic control. Results presented in this study suggest that administration of TTFE for 21 days normalized STZ‐induced hyperglycemia and its associated dyslipidemia by a mechanism involving inhibition of α‐amylase and HMG‐CoA reductase activities, respectively, in rats.

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The role of dietary polyphenols in the management of erectile dysfunction–Mechanisms of action

Cited by 28 publications

References 66 publications

Sexual Enhancing Effect of Anacardium occidentale in Stress-Exposed Rats by Improving Dopaminergic and Testicular Functions

Sexual Enhancing Effect of Anacardium occidentale in Stress-Exposed Rats by Improving Dopaminergic and Testicular Functions

Management of Benign Prostatic Hyperplasia: Could Dietary Polyphenols Be an Alternative to Existing Therapies?

Effects of Talinum triangulare leaf flavonoid extract on streptozotocin‐induced hyperglycemia and associated complications in rats

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