The role of dietary polyphenols in the moderation of the inflammatory response in early stage colorectal cancer

Little, Cariss; Combet, Emilie; McMillan, Donald C.; Horgan, Paul G.; Roxburgh, Campbell S.D.

doi:10.1080/10408398.2014.997866

Cited by 28 publications

(20 citation statements)

References 134 publications

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“…As a matter of fact, polyphenol-rich propolis extracts have been demonstrated to possess anti-inflammatory properties through regulation of I κ B- α /NF- κ B/p65 pathway by specifically delaying the ubiquitination of TRAF 6 [23]. Many other studies have also suggested that dietary polyphenols have many targets to attenuate inflammation, including but not limited to STAT, PI3K, and COX [24]. The exact target of M against inflammation is being explored in our laboratory.…”

Section: Discussionmentioning

confidence: 99%

Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting IκBα/NFκB and Enhancing Nrf2/HO‐1

Liao

Zhu

Hong

et al. 2017

Oxidative Medicine and Cellular Longevity

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Diabetic cardiomyopathy (DCM) is associated with a greater risk of mortality in patients with diabetes mellitus. Currently, no specific treatment has been suggested for DCM treatment. This study demonstrated that myricetin (M) attenuated DCM-associated cardiac injury in mice subjected to streptozotocin (SZT) and in neonatal rat cardiomyocytes (NRCM) challenged with high glucose. In vivo investigation demonstrated 6 months of M treatment (200 mg/kg/d) significantly alleviated cardiac hypertrophy, apoptosis, and interstitial fibrosis. Mechanically, M treatment significantly increased the activity of Nrf2/HO-1 pathway, strengthening antioxidative stress capacity evidenced by reversed activities of GPx and SOD, and decreased MDA production. M treatment also inhibited IκBα/NF-κB pathway, resulting in reduced secretion of inflammation cytokines including IL-1β, TNF-α, and IL-6. Besides, the TGFβ/Smad3 signaling was also blunted in DCM mice treated with M. These beneficial effects of M treatment protected cardiomyocytes from apoptosis as shown by decreased TUNEL-positive nucleus, c-caspase 3, and Bax. Similar effects of M treatment could be reproduced in NRCM treated with high glucose. Furthermore, through silencing Nrf2 in NRCM, we found that the regulation of IκBα/NFκB by M was independent on its function on Nrf2. Thus, we concluded that M possesses potential protective effects on DCM through inhibiting IκBα/NFκB and enhancing Nrf2/HO-1.

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Section: Discussionmentioning

confidence: 99%

Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting IκBα/NFκB and Enhancing Nrf2/HO‐1

Liao

Zhu

Hong

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…There is an emerging body of work on the potential impact of (poly)phenolic metabolites on age-related factors (inflammation, oxidative stress, glycation, dysbiosis) contributing to chronic diseases such as CRC [9][10][11][12][13][14]. Recently, the International Scientific Association for Probiotics and Prebiotic expanded the definition of the prebiotics to include (poly)phenolics as they are selectively metabolised by gut microbiota and release microbial bioactive molecules (including phenolic acids) that may confer local and systematic health benefits [15].…”

Section: Electronic Supplementary Materialsmentioning

confidence: 99%

The urinary phenolic acid profile varies between younger and older adults after a polyphenol-rich meal despite limited differences in in vitro colonic catabolism

2018

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Purpose To investigate whether age influences colonic polyphenol metabolism. Methods Healthy participants, younger (n = 8; 23-43 years) and older (n = 13; 51-76 years), followed a 3-day low-polyphenol diet (LPD) and a 3-day high-polyphenol diet (HPD). Urinary phenolic acids (PA), short chain fatty acids (SCFA), pH and gas were monitored, alongside selected colonic bacteria. Human faecal in vitro fermentations of rutin with or without raftiline were used to evaluate the gut microbiota capacity in a subset of both groups. Results Total urinary PA were higher in the older group after HPD compared to the younger group (1.5-fold; p = 0.04), with no difference between groups in terms of a change between diets (Δ high-low diet). While 17 PA were detected in all younger participants after HPD, a narrower range (n = 8 to 16 PA) was detected in most (n = 9/13) older participants, with lower level of benzoic acid (19-fold; p = 0.03), vanillic acid (4.5-fold; p = 0.04) but higher hippuric acid (2.7-fold; p = 0.03). Faecal SCFA concentration did not change after HPD within group, with similar differential excretion (Δ high-low diet) between groups. There were no differences between groups for faecal pH, total, faecal bacteria including Flavonifractor plautii, bifidobacteria, and bacteroides. In human in vitro faecal fermentations, seven PAs were detected in both groups after 24 h of rutin fermentation, with no quantitative and modest qualitative differences between groups. Total SCFA in faecal fermentation did not differ between groups, except for butyric acid (twofold higher in the older group; p = 0.009) when rutin was fermented with raftiline over 24 h. Conclusions Urinary phenolic acids were less diverse in older participants despite limited difference in functional capacity of in vitro faecal fermentations.

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“…[57,58] As noted in the previous sections, quercetin, kaempferol, catechins, resveratrol, rutin, and their derivatives are known for their health benefits in humans and the prevention of various HDs (especially cancer, cardiovascular diseases, diabetes, obesity, liver disorder, and infectious diseases). [17,27,31,38,[59][60][61][62][63][64][65][66] Since fruits, especially apples, pears, apricots, cherries, berries, and grape, and vegetables, such as carrot, tomato, onion, garlic, cabbage, and celery, contain up to 200-300 mg of PCs per 100 g of their fresh weight, they can be used as dietary supplements of PCs. [67] The presence of these compounds in food and pharmaceutical industries has improved the quality of food and drugs.…”

Section: Which Compounds Received More Attention?mentioning

confidence: 99%

Polyphenols and their benefits: A review

Rasouli

Farzaei

Khodarahmi

2017

International Journal of Food Properties

307

259

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Let food be thy medicine and medicine be thy food" was expressed by Hippocrates more than 2000 years ago and the health benefits of natural food products have been considered for different goals since the ancient times. As natural phytochemicals, phenolic compounds (PCs) are a major class of semi-water-soluble compounds (from fruit and vegetable sources) with one or more benzene rings that are generally found in nature as glycosides. According to a review of the literature, food scientists have studied the many health benefits of these compounds against pernicious human diseases (HDs). Today, choosing a healthy diet has become an essential part of healthy living and fitness. Many studies have shown that people who follow a specific diet (especially polyphenol-rich diets) are at a low risk for a range of chronic diseases, such as obesity, diabetes, cancer, heart disease, etc. The present research is a comprehensive review of studies on PCs with a focus on HDs that seeks to find out why some PCs have received such considerable attention all over the world. Data were collected from the Scopus database and a hierarchical cluster analysis was used with Ward's method to analyze the data. The results showed that three countries most involved in research on PCs are USA, China, and India, and also found that quercetin, catechin, and kaempferol are the three most studied PCs. Cardiovascular diseases, cancer, obesity, diabetes, and infectious diseases are the major treatment targets for PCs. The review of the literature showed that these compounds share a common molecular mode of action against HDs. The Journal of Agriculture and Food Chemistry, Food Chemistry, PLOS ONE, and Planta Medica are also the most popular journals for covering original research on PCs. However, this study seeks to facilitate future studies on PCs through its findings.

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The role of dietary polyphenols in the moderation of the inflammatory response in early stage colorectal cancer

Cited by 28 publications

References 134 publications

Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting IκBα/NFκB and Enhancing Nrf2/HO‐1

Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting IκBα/NFκB and Enhancing Nrf2/HO‐1

The urinary phenolic acid profile varies between younger and older adults after a polyphenol-rich meal despite limited differences in in vitro colonic catabolism

Polyphenols and their benefits: A review

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