The role of diuretic hormones (DHs) and their receptors in Drosophila

Abstract

Maintaining internal homeostasis and regulating innate behaviors are essential for animal survival. In various animal species, a highly conserved neuroendocrine system integrates sensory inputs and regulates physiological responses to environmental and internal changes. Diuretic hormones 44 and 31, which are homologs of mammalian corticotropin-releasing factor (CRF) and calcitonin gene-related peptide (CGRP), respectively, control body fluid secretion in Drosophila. These neuropeptides and their receptors have multiple physiological roles, including the regulation of body-fluid secretion, sleep:wake cycle, internal nutrientsensing, and CO2-dependent response. This review discusses the physiological and behavioral roles of DH44 and DH31 signaling pathways, consisting of neuroendocrine cells that secrete DH44 or DH31 peptides and their receptor-expressing organs. Further research is needed to understand the regulatory mechanisms of the behavioral processes mediated by these neuroendocrine systems. BMB Rep. www.bmbreports.org Invited Mini ReviewThe role of DHs and their receptors in Drosophila Gahbien Lee, et al.

Cellular and molecular organization of the Drosophila foregut

“…Body temperature regulation is mediated by Dh31/Dh31-R in Drosophila. In vertebrates, the Dh31-R ortholog, the calcitonin receptor (CalcR), controls body temperature ( 78 , 79 ). Circadian clock regulation of many aspects of animal physiology is also conserved ( 80 , 81 ).…”

Structural and functional characterization of an egg-laying hormone signaling system in a lophotrochozoan – The pacific oyster (Crassostrea gigas)

“…Both vertebrate CRH family peptides and ecdysozoan DH44 are key players of the physiological response or tolerance to stress (Cannell et al, 2016;Deussing and Chen, 2018) and are involved in the regulation of a variety of physiological functions including feedingassociated processes (Cannell et al, 2016;Czimmer and Tache, 2017;Dus et al, 2015;Stengel and Taché, 2014;van Wielendaele et al, 2012), immunity (Lee et al, 2023), reproduction (van Wielendaele et al, 2012, body fluid secretion in Drosophila (Cabrero et al, 2002) and the renal function (Devetzis et al, 2013). Among Lophotrochozoa, besides gastropod ELHs, only a first insight into the physiological role of ELH as an egg-laying (spawning) hormone had been provided so farin the Sydney rock oyster (Saccostrea glomerata) (In et al, 2016).…”