The role of doxycycline in the management of chronic rhinosinusitis with nasal polyps

International consensus statement on allergy and rhinology: rhinosinusitis 2021

“…Most recently, Parasher et al attempted to study doxycycline against placebo in an RCT for CRSwNP with moderate to severe symptoms as measured on a VAS 1624 . Patients were randomized to a 20‐day course of doxycycline or placebo; both groups were also prescribed an oral methylprednisolone taper.…”

Chronic Rhinosinusitis With Nasal Polyps: Quality of Life in the Biologics Era

“…Antibiotics such as azithromycin and doxycycline are occasionally used in CRSwNP treatment. [100][101][102][103][104] Because of limited evidence, the use of leukotriene receptor antagonists (eg, montelukast) is not recommended. 2,105 Our search results include studies showing significant improvements in QoL after medical therapy, including consistent short-term efficacy with intranasal corticosteroids (spray, drops, or exhalation delivery systems) 106 and oral corticosteroids (Table EI).…”

Data_Sheet_1.docx

“…The number of prescribed antibiotics in this study is likely to be an under-estimation due to some missing data, and it is important to note that we are relying on prescription information to reflect patients' actual antibiotic intake. One recent study has shown that despite intensive antibiotic prescription, no effects of antibiotic treatment on radiological (Lund-Mackay) and outcome scores (SNOT-22) were observed (Parasher et al, 2019). Our results indicated no differences in patient outcome between patients with pre-operative prescriptions of antibiotics and nonantibiotic users.…”