Climate models agree that semi-arid regions around the world are likely to experience increased rainfall variability and longer droughts in the coming decades. In regions dependent on agriculture, such changes threaten to aggravate existing food insecurity and economic underdevelopment, and to push migration to urban areas. In the Brazilian semi-arid region, the Sertão, farmers' vulnerability to climate-past, present, and future-stems from several factors, including low yielding production practices and reliance on scarce and seasonally variable water resources. Using interpolated local climate data, we show that, since 1962, in the Bacia do Jacuípe-one of the poorest regions in the Sertão of Bahía state-average temperatures have increased~2°C and rainfall has decreased~350 mm. Over the same time period, average milk productivity-the main rural economic activity in the county-has fallen while in Brazil and in Bahía as a whole milk productivity has increased dramatically. This paper teases apart the drivers of climate vulnerability of the Bacia do Jacuípe in relation to the rest of Bahía. We then present the results of a suite of pilot projects by Adapta Sertão, a coalition of organizations working to improve the adaptive capacity of farmers living in the semi-arid region. By testing a number of different technologies and arrangements at the farm level, Adapta Sertão has shown that interventions focused on balanced animal diets and efficient irrigation systems can help reduce (but not eliminate) the dependence of production systems