The role of E and N-cadherin in the postoperative course of gonadotroph pituitary tumours

Øystese, Kristin Astrid Berland; Berg, Jens Petter; Normann, Kjersti Ringvoll; Zucknick, Manuela; Casar‐Borota, Olivera; Bollerslev, Jens

doi:10.1007/s12020-018-1679-0

Cited by 19 publications

(34 citation statements)

References 43 publications

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“…The ECM plays a critical role in tumorigenesis and invasiveness/aggressiveness in several cancers, being a bridge between cell differentiation and proliferation, angiogenesis, and cell motility. The epithelial–mesenchymal transition process (EMT) has previously been studied in several subtypes of pituitary tumors and found to be of importance for both hormone production and aggressiveness [ 38 , 39 , 40 , 41 ]. Interestingly, in a recent multi-omics study, the silent corticotroph tumors presented low EMT, whereas USP8-wild-type functioning tumors showed and increased EMT, somehow challenging the classical imagistic phenotype of SCA as an aggressive tumor [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Distinct Pattern of Endoplasmic Reticulum Protein Processing and Extracellular Matrix Proteins in Functioning and Silent Corticotroph Pituitary Adenomas

Eieland

Normann

Sundaram

et al. 2020

Cancers

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Functioning (FCA) and silent corticotroph (SCA) pituitary adenomas act differently from a clinical perspective, despite both subtypes showing positive TBX19 (TPIT) and/or adrenocorticotropic hormone (ACTH) staining by immunohistochemistry. They are challenging to treat, the former due to functional ACTH production and consequently hypercortisolemia, and the latter due to invasive and recurrent behavior. Moreover, the molecular mechanisms behind their distinct behavior are not clear. We investigated global transcriptome and proteome changes in order to identify signaling pathways that can explain FCA and SCA differences (e.g., hormone production vs. aggressive growth). In the transcriptomic study, cluster analyses of differentially expressed genes revealed two distinct groups in accordance with clinical and histological classification. However, in the proteomic study, a greater degree of heterogeneity within the SCA group was found. Genes and proteins related to protein synthesis and vesicular transport were expressed by both adenoma groups, although different types and a distinct pattern of collagen/extracellular matrix proteins were presented by each group. Moreover, several genes related to endoplasmic reticulum protein processing were overexpressed in the FCA group. Together, our findings shed light on the different repertoires of activated signaling pathways in corticotroph adenomas, namely, the increased protein processing capacity of FCA and a specific pattern of adhesion molecules that may play a role in the aggressiveness of SCA.

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Section: Discussionmentioning

confidence: 99%

Distinct Pattern of Endoplasmic Reticulum Protein Processing and Extracellular Matrix Proteins in Functioning and Silent Corticotroph Pituitary Adenomas

Eieland

Normann

Sundaram

et al. 2020

Cancers

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“…Oestrogen induces expression of pituitary tumour transforming gene (PTTG) 50 and modulates epithelial-cadherin (E-cadherin). 51 In a cohort study of NFPT, increased ERα together with decreased E-cadherin and ERβ expression were observed in invasive compared with non-invasive tumours. 52 By contrast, other studies have linked loss of ERα expression with propensity for resistance to conventional therapies and early re-intervention in lactotroph and NFPT.…”

Section: Oestrogen Receptor α (Erα)mentioning

confidence: 97%

“…71,72 During EMT, membranous E-cadherin is translocated to the nucleus. 51 Several studies have demonstrated…”

Section: Epithelial-mesenchymal Transition (Emt) and Extracellular Matrix (Ecm) Degradationmentioning

confidence: 99%

“…In NFPT, downregulation of membranous E-cadherin expression was observed in invasive compared to non-invasive counterparts, and also correlated with reintervention. 51,52 PITX2 is a transcription factor associated with normal pituitary organogenesis, cell differentiation and proliferation. PITX2 expression has been correlated with tumour invasiveness, facilitated by a proposed anti-apoptotic role during NFPT tumorigenesis.…”

Section: Ecm Degradation Mmp-9mentioning

confidence: 99%

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Towards precision medicine for clinically non‐functioning pituitary tumours

Lenders

Inder

McCormack

2021

Clinical Endocrinology

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Objective: Clinically non-functioning pituitary tumours (NFPT) are a heterogenous group of neoplasms with diverse outcomes. The purpose of this narrative review was to summarize available data on predictive factors, both in routine practice and research settings.Design: A literature review was conducted for papers published in peer-reviewed journals, investigating clinical, radiological, pathological and genetic predictive factors in NFPT.Results: Several clinical and radiological factors have been associated with NFPT recurrence and/or aggressiveness, including larger size and pre-/post-operative growth rates. Application of transcription factor immunohistochemistry has given rise to improved subtype identification, including 'higher-risk' subtypes, in routine clinical practice. Numerous other pathological and genetic biomarkers have demonstrated promise for prognostication in the research setting. Conclusion:NFPT are a heterogenous group of tumours, characterized by diverse presentation, pathogenesis and outcomes. Ongoing refinements in understanding of tumour biology are likely to pave the way to improved integrative prognostication and precision medicine for NFPT.

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“…The cadherin family, a class of Ca 2+ -dependent transmembrane glycoproteins, serves an important role in tissue morphogenesis and coordination of cell movement(42). E-cadherin and N-cadherin are two representatives of the cadherin family and are associated with EMT(43,44). Thus, increases in MMP2, MMP9, N-cadherin…”

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confidence: 99%

Downregulation of lncRNA ZFAS1 inhibits the hallmarks of thyroid carcinoma via the regulation of miR‑302‑3p on cyclin D1

et al. 2020

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At present, treatment options for thyroid carcinoma remain limited. The present study aimed to investigate the role of ZFAS1 in various major hallmarks of cancer and the underlying mechanisms in thyroid carcinoma cells. The interactions between long non-coding RNAs (lncRNAs), microRNAs (miRs) and target genes were predicted by bioinformatics and confirmed by performing dual-luciferase assays. The mRNA and protein expressions were determined by reverse transcription-quantitative PCR and western blotting. Cell invasion, migration, and viability were evaluated via Transwell, wound-healing and Cell Counting Kit-8 assays, respectively. The results demonstrated that lncRNA ZFAS1 expression was upregulated in thyroid carcinoma tissues, TT and SW579 cells, and was associated with the proliferation of these two cell lines. Notably, downregulation ZFAS1 reduced migration and invasion, and reversed the promotive effects of miR-302a-3p inhibitor on the proliferation, migration and invasion of TT and SW579 cells. Moreover, cyclin D1 (CCND1) is targeted by miR-302a-3p, and was regulated by ZFAS1. In addition, the downregulation of ZFAS1 not only reversed the promotive effects of miR-302a-3p inhibitor on CCND1 expression and the epithelial-mesenchymal transition (EMT) of TT and SW579 cells, but also targeted and increased the expression of miR-302a-3p, and further reduced the expression of CCND1, resulting in suppression of the proliferation, migration, invasion and EMT of thyroid carcinoma cells.

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The role of E and N-cadherin in the postoperative course of gonadotroph pituitary tumours

Cited by 19 publications

References 43 publications

Distinct Pattern of Endoplasmic Reticulum Protein Processing and Extracellular Matrix Proteins in Functioning and Silent Corticotroph Pituitary Adenomas

Distinct Pattern of Endoplasmic Reticulum Protein Processing and Extracellular Matrix Proteins in Functioning and Silent Corticotroph Pituitary Adenomas

Towards precision medicine for clinically non‐functioning pituitary tumours

Downregulation of lncRNA ZFAS1 inhibits the hallmarks of thyroid carcinoma via the regulation of miR‑302‑3p on cyclin D1

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The role of E and N-cadherin in the postoperative course of gonadotroph pituitary tumours

Cited by 19 publications

References 43 publications

Distinct Pattern of Endoplasmic Reticulum Protein Processing and Extracellular Matrix Proteins in Functioning and Silent Corticotroph Pituitary Adenomas

Distinct Pattern of Endoplasmic Reticulum Protein Processing and Extracellular Matrix Proteins in Functioning and Silent Corticotroph Pituitary Adenomas

Towards precision medicine for clinically non‐functioning pituitary tumours

Downregulation of lncRNA ZFAS1 inhibits the hallmarks of thyroid carcinoma via the regulation of miR‑302‑3p on cyclin&nbsp;D1

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Downregulation of lncRNA ZFAS1 inhibits the hallmarks of thyroid carcinoma via the regulation of miR‑302‑3p on cyclin D1