The role of E3 ubiquitin-ligases MuRF-1 and MAFbx in loss of skeletal muscle mass

Rom, Oren; Reznick, Abraham Z.

doi:10.1016/j.freeradbiomed.2015.12.031

Cited by 185 publications

(162 citation statements)

References 159 publications

(255 reference statements)

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“…Its expression is decreased by the activation of insulin signaling pathway and facilitated by the increase in the protein expression of tumor necrosis factor-␣ (TNF-␣) in skeletal muscle (51)(52)(53). KKAy mice have been reported to show decreased proteins level of insulin signaling pathway and increased mRNA expression of TNF-␣ in skeletal muscle (54)(55)(56).…”

Section: Discussionmentioning

confidence: 99%

Effects of Aerobic Exercise Combined with Panaxatriol Derived from Ginseng on Insulin Resistance and Skeletal Muscle Mass in Type 2 Diabetic Mice

Takamura

Nomura

Uchiyama

et al. 2017

J Nutr Sci Vitaminol

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Summary Insulin resistance reduces insulin-induced muscle protein synthesis and accelerates muscle protein degradation. Ginseng ingestion has been reported to improve insulin resistance through the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway. We hypothesized that panaxatriol (PT) derived from ginseng in combination with aerobic exercise (EX) may further promote protein synthesis and suppress protein degradation, and subsequently maintain muscle mass through the amelioration of insulin resistance. KKAy insulin-resistant mice were divided into control, panaxatriol only (PT), exercise only (EX), and EXϩPT groups. EX and EXϩPT ran on the treadmill for 45 min at 15 m/min 5 d/wk for 6 wk. PT and EXϩPT groups were fed a standard diet containing 0.2% PT for 6 wk. Homeostasis model assessment for insulin resistance (HOMA-R) values was significantly improved after exercise for 6 wk. Moreover, EXϩPT mice showed improved HOMA-R as compared to EX mice. p70S6K phosphorylation after a 4 h fast was significantly higher in EX than in the non-exercise control, and it was higher in EXϩPT mice than in EX mice. Atrogin1 mRNA expression was significantly lower in EX than in the non-exercise control, and was significantly lowered further by PT treatment. EX and EXϩPT mice showed higher soleus muscle mass and cross-sectional area (CSA) of the soleus myofibers than control animals, with higher values noted for both parameters in EXϩPT than in EX. These results suggest that aerobic exercise and PT ingestion may contribute to maintain skeletal muscle mass through the amelioration of insulin resistance.

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Section: Discussionmentioning

confidence: 99%

Effects of Aerobic Exercise Combined with Panaxatriol Derived from Ginseng on Insulin Resistance and Skeletal Muscle Mass in Type 2 Diabetic Mice

Takamura

Nomura

Uchiyama

et al. 2017

J Nutr Sci Vitaminol

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“…FOXOs activate lysosomal cathepsins and cytosolic protease calpains which progresses towards ATP-dependent UPS activation via FOXO3a associated MuRF-1 and MAFbx regulation [reviewed in (66, 117)]. Thus, FOXO mediated autophagy via the UPS may be an important regulator of muscle mass in aging.…”

Section: Foxo Proteins and The Ubiquitin Proteasome System (Ups) In Mmentioning

confidence: 99%

Mitochondria Initiate and Regulate Sarcopenia

Alway

Mohamed

Myers

2017

Exercise and Sport Sciences Reviews

114

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“…muscle atrophy F box (encoded by MAFbx/atrogin-1) and muscle RING finger 1 (MuRF1)], which cause polyubiquitation of proteins targeted for degradation. [95]…”

Section: 2 Pathophysiology Of Cimwmentioning

confidence: 99%

Bone Pain and Muscle Weakness in Cancer Patients

Milgrom

Lad

Koniaris

et al. 2017

Curr Osteoporos Rep

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Purpose of review In this article we will discuss the current understanding of bone pain and muscle weakness in cancer patients. We will describe the underlying physiology and mechanisms of cancer-induced bone pain (CIBP) and cancier-induced muscle wasting (CIMW), as well as current methods of diagnosis and treatment. We will discuss future therapies and research directions to help patients with these problems. Recent Findings There are several pharmacologic therapies that are currenly in pre-clinical and clinical testing that appear to be promising adjuncts to current CIBP and CIMW therapies. Such therapies include resiniferitoxin, which is a targeted inhibitor of nociptive nerve fibers, and selective androgen receptor modulators, which show promise in increasing lean mass. Summary CIBP and CIMW are a significant causes of morbidity in affected patients. Current management is mostly palliative; however, targeted therapies are poised to revolutionize how these problems are treated.

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The role of E3 ubiquitin-ligases MuRF-1 and MAFbx in loss of skeletal muscle mass

Cited by 185 publications

References 159 publications

Effects of Aerobic Exercise Combined with Panaxatriol Derived from Ginseng on Insulin Resistance and Skeletal Muscle Mass in Type 2 Diabetic Mice

Effects of Aerobic Exercise Combined with Panaxatriol Derived from Ginseng on Insulin Resistance and Skeletal Muscle Mass in Type 2 Diabetic Mice

Mitochondria Initiate and Regulate Sarcopenia

Bone Pain and Muscle Weakness in Cancer Patients

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