The Role of Early Treatment in the Management of Axial Spondyloarthritis: Challenges and Opportunities

Mauro, Daniele; Forte, Giulio; Poddubnyy, Denis; Ciccia, Francesco

doi:10.1007/s40744-023-00627-0

Rheumatol Ther

2023

DOI: 10.1007/s40744-023-00627-0

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The Role of Early Treatment in the Management of Axial Spondyloarthritis: Challenges and Opportunities

Daniele Mauro,

Giulio Forte,

Denis Poddubnyy

et al.

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2024

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Cited by 7 publications

References 86 publications

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A qualitative exploration of the patient journey in axial spondyloarthritis towards a people-centered understanding

Berr,

Ziehfreund,

Welcker

et al. 2024

Sci Rep

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This exploratory qualitative study aims to gain a people-centered understanding of the patient journey in axial spondyloarthritis (axSpA). Semi-structured interviews were conducted with 15 individuals diagnosed with axSpA, aged 18 years and older, who were purposively recruited from a rheumatologic practice in southern Germany. The interviews were carried out as web-based video calls between September and October 2021, audio-recorded, transcribed verbatim, and analyzed according to Kuckartz’s qualitative content analysis. Patient journey narratives encompassed both healthcare journeys and personal journeys. Healthcare journeys were characterized as fragmented and difficult to navigate, with diagnosis often marking a turning point toward more coordinated care. Post-diagnosis, new challenges emerged (e.g., time management for treatment). Personal journeys comprised perceptions of axSpA in social contexts (e.g., stigmatization) and the continuous interplay of comorbidities and biographical events with healthcare related to axSpA. This study proposes a people-centered perspective on the patient journey in axSpA, emphasizing the interplay of biographies, comorbidities, and social context with healthcare events. Recognizing these personal factors in clinical practice is encouraged to address complex health needs and tailor treatment to each individual. Further efforts should promote collaboration between medical disciplines and integrate healthcare and social support at all stages of the axSpA patient journey.

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A qualitative exploration of the patient journey in axial spondyloarthritis towards a people-centered understanding

Berr,

Ziehfreund,

Welcker

et al. 2024

Sci Rep

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Early psoriatic arthritis: clinical and therapeutic challenges

Caso,

Costa,

Megna

et al. 2024

Expert Opinion on Investigational Drugs

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British Axial Spondyloarthritis Inception Cohort (BAxSIC): a protocol for a multicentre real-world observational cohort study of early axial spondyloarthritis

Weddell,

Harrison,

Bennett

et al. 2024

Rheumatology Advances in Practice

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Objectives Timely diagnosis remains a challenge in axial Spondyloarthritis (axSpA). In addition, data are scarce on the impact of diagnostic delay and disease progression in affected individuals. The British Axial Spondyloarthritis Inception Cohort (BAxSIC) study aims to investigate the impact of newly diagnosed axSpA, the natural history of the disease and the effect of diagnostic delay on disease outcomes. Methods BAxSIC is a prospective, multi-centre, observational study. Eligible participants are adults (aged 16 years old or over), with a physician-confirmed diagnosis of axial Spondyloarthritis in the six months prior to study entry, recruited from secondary and tertiary rheumatology centres in the United Kingdom (UK). Participants will be followed up for 3 years, with in-person visits at baseline and 24 months. In addition, patient self-reported assessments (PROMs questionnaires) will be recorded remotely via the online electronic case report form (eCRF) at 6, 12, 18, 30 and 36 months. Results Trial status: The first patient was enrolled in BAxSIC in June 2023. Recruitment is currently ongoing and is planned to end in June 2026. Initial results will be available in 2027. Since opening, the trial has undergone two protocol amendments. Conclusion The BAxSIC study is the first inception cohort designed to investigate the impact of diagnostic delay on clinical presentation and long-term functional outcomes in patients with axSpA in the UK. With an innovative, patient-led virtual longitudinal data collection model, data generated from this study will help inform and improve the care of people newly diagnosed with axSpA.

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The Role of Early Treatment in the Management of Axial Spondyloarthritis: Challenges and Opportunities

Cited by 7 publications

References 86 publications

A qualitative exploration of the patient journey in axial spondyloarthritis towards a people-centered understanding

A qualitative exploration of the patient journey in axial spondyloarthritis towards a people-centered understanding

Early psoriatic arthritis: clinical and therapeutic challenges

British Axial Spondyloarthritis Inception Cohort (BAxSIC): a protocol for a multicentre real-world observational cohort study of early axial spondyloarthritis

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