This study aimed to determine the pattern of cannabis and tobacco use among adolescent students in Sokoto and measure antinutritional factors in the two drugs. Qualitative and quantitative standard methods were applied.Reagents and materials of analytical grade were used to evaluate the antinutrients. Signs of drug abuse among adolescents are untidiness (33.3%), blackening of lips and toes (24.2%), poor concentration (20.0%), poor/foul odor (12.1%), false images (6.7%), hostility (5.5%), and reduced weight (1.2%). The perceived causes of drug abuse are peer pressure (36.4%), poor parental guidance (30.3%), labor/work (15.2%), learning musical art (9.1%), unemployment (6.1%), and sports (3.0%). The submitted effects linked to cannabis and cigarette revealed are health effects (27.3%), followed by poor academic performance (24.2%), confusion (21.2%), school dropout (16.9%), disrespect (7.3%), and lastly disrespect (3.0%). The preventions are strict restriction on drugs (33.3%), education/awareness about the effects of drug abuse (26.7%), religious intervention (21.2%), avoiding deviant peers (9.7%), and poor parental guidance (9.1%). Substance abuse is a menace among the studied adolescents, and antinutrients present in the drugs affect the users, especially their academic performance.