The Role of Emollients in the Management of Diseases with Chronic Dry Skin

Proksch, Ehrhardt

doi:10.1159/000112957

Cited by 64 publications

(59 citation statements)

References 66 publications

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“…Deficient skin barrier function leading to increased transepidermal water loss (TEWL) and decreased stratum corneum hydration (dry skin) is a characteristic feature of AD (22,23). Clinical studies showed that the daily use of skin care products may prevent AD or can prolong the time between flare-ups (24)(25)(26).…”

Section: Atopic Dermatitismentioning

confidence: 99%

Topical use of dexpanthenol: a 70th anniversary article

Proksch

Bony

Trapp

et al. 2017

Journal of Dermatological Treatment

117

143

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Approximately 70 years ago, the first topical dexpanthenol-containing formulation (Bepanthen TM Ointment) has been developed. Nowadays, various topical dexpanthenol preparations exist, tailored according to individual requirements. Topical dexpanthenol has emerged as frequently used formulation in the field of dermatology and skin care. Various studies confirmed dexpanthenol's moisturizing and skin barrier enhancing potential. It prevents skin irritation, stimulates skin regeneration and promotes wound healing. Two main directions in the use of topical dexpanthenol-containing formulations have therefore been pursued: as skin moisturizer/skin barrier restorer and as facilitator of wound healing. This 70th anniversary paper reviews studies with topical dexpanthenol in skin conditions where it is most frequently used. Although discovered decades ago, the exact mechanisms of action of dexpanthenol have not been fully elucidated yet. With the adoption of new technologies, new light has been shed on dexpanthenol's mode of action at the molecular level. It appears that dexpanthenol increases the mobility of stratum corneum molecular components which are important for barrier function and modulates the expression of genes important for wound healing. This review will update readers on recent advances in this field. ARTICLE HISTORY

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Section: Atopic Dermatitismentioning

confidence: 99%

Topical use of dexpanthenol: a 70th anniversary article

Proksch

Bony

Trapp

et al. 2017

Journal of Dermatological Treatment

117

143

View full text Add to dashboard Cite

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“…18 Topical moisturizers are beneficial for managing dry skin, 19 with many studies showing demonstrable improvements in skin condition compared to use of a moisturizer with placebo base cream, although no conclusive recommendations were reached in a systematic review. 20 Although no particular ingredient or formulation of moisturizer could be recommended, this study revealed that application of moisturizer for prevention of fissure in patients with diabetes should be followed for a suggested skin hydration of 20.0%.…”

Section: Relevance To Clinical Practicementioning

confidence: 99%

Skin hydration of the heel with fissure in patients with diabetes: a cross-sectional observational study

Oe¹,

Takehara²,

Noguchi³

et al. 2018

CWCMR

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Purpose: Foot fissure should be prevented in patients with diabetes due to the likelihood of subsequent diabetic ulcer. The purpose of this study was to investigate a cutoff point for skin hydration with fissure and the factors associated with low skin hydration in patients with diabetes. Subjects and methods: Subjects were patients with diabetes who visited the diabetic foot clinic and were evaluated for skin hydration on the heel between April 2008 and March 2015. Information about fissure, skin hydration, age, sex, autonomic neuropathy, angiopathy, and tinea pedis were collected from the medical charts. Skin hydration on the heel was measured using a moisture checker. Skin hydration was compared between heels with and without fissure, and a cutoff for skin hydration with fissure was determined using receiver operating characteristic analysis. Based on the determined cutoff, factors associated with lower skin hydration were analyzed using logistic regression analysis. Results: Participants comprised 693 patients. Mean±SD age was 66.8±10.8 years, and 57.0% of subjects were male. The frequency of fissures on the heels was 10.4%. Area under the receiver operating characteristic curve for skin hydration in the presence of fissure was 0.717. Twenty percent was selected as the cutoff point, offering sensitivity of 0.478 and specificity of 0.819. Logistic regression analysis showed correlations between three factors (male sex, tinea pedis, and room temperature) and skin hydration <20.0% (odds ratio [OR] 1.587, 95% CI 1. p=0.004; OR 1.548, p=0.005; and OR 0.900, p=0.021, respectively). Conclusion: To prevent heel fissures, moisturizing care should aim at achieving skin hydration of 20%. If skin hydration is <20%, prevention of fissures may warrant not only specialized moisturizing care but also consideration of treatment for tinea pedis.

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“…American Diabetes Association -ADA) stosowanie emolientów jest wskazane u diabetyków w profilaktyce suchej skóry i świądu [40]. Emolienty to preparaty miejscowo nawilżające i natłuszczające skórę.…”

Section: Pielęgnacja Skóry Cukrzycowejunclassified

Molecular factors involved in skin dryness in diabetic patients

Bednarski¹,

Lesiak²

2016

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STRESZCZENIECukrzyca, która jest chorobą przewlekłą oraz układową, dotyka aż 8,3% populacji ogólnej i staje się poważnym problemem klinicznym i finansowym dla systemów opieki zdrowotnej na świecie. Powikłania cukrzycy obejmują zarówno uszkodzenia wielu narządów wewnętrz-nych, jak i zmiany skórne, które mogą wyprzedzać kliniczne objawy cukrzycy. Ponadto skóra diabetyków często jest podrażniona i przesuszona, co przyczynia się do zwiększonego ryzyka występowania infekcji skórnych. Niemniej niewiele dotychczas wiadomo na temat molekularnych podstaw zmian zachodzących w skórze w przebiegu cukrzycy. Wszystkie prowadzone do tej pory badania koncentrują się wokół uszkodzenia bariery naskórkowej, zaburzeń integralności naskórka oraz zaburzeń funkcjonowania gruczołów łojowych. Innym, złożonym problemem jest sama pielęgnacja skóry osób chorujących na cukrzycę. Kompleksowe zrozumienie procesów zachodzących na poziomie komórkowym mogłoby pozwolić na odkrycie nowych markerów monitorujących skuteczność stosowanego leczenia zmian skórnych oraz nowych preparatów pielęgnacyjnych. ABSTRACTDiabetes is a chronic systemic disease affecting 8.3% of the general population, thus constituting an important clinical and financial problem for healthcare systems throughout the world. Complications of diabetes damage both many internal organs and skin. Skin complications of diabetes can anticipate its clinical symptoms. Diabetic skin, irritated and dry in many cases, is susceptible to skin infections. However, there is little known about molecular changes in skin in diabetes. Many studies are concentrated on epidermal barrier damage, dysfunction of epidermis integrity and dysfunction of sebaceous glands. Another complex problem is skin care in diabetic patients. A profound understanding of cellular-level processes in diabetes could lead to the discovery of new therapy efficacy markers and new skin care products. SŁOWA KLUCZOWE:cukrzyca, sucha skóra, emolienty.

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The Role of Emollients in the Management of Diseases with Chronic Dry Skin

Cited by 64 publications

References 66 publications

Topical use of dexpanthenol: a 70th anniversary article

Topical use of dexpanthenol: a 70th anniversary article

Skin hydration of the heel with fissure in patients with diabetes: a cross-sectional observational study

Molecular factors involved in skin dryness in diabetic patients

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