The Role of EMT-Related lncRNAs in Ovarian Cancer

Abstract

Ovarian cancer (OC) is one of the deadliest cancers worldwide; late diagnosis and drug resistance are two major factors often responsible for high morbidity and treatment failure. Epithelial-to-mesenchymal transition (EMT) is a dynamic process that has been closely linked with cancer. Long non-coding RNAs (lncRNAs) have been also associated with several cancer-related mechanisms, including EMT. We conducted a literature search in the PubMed database in order to sum up and discuss the role of lncRNAs in regulating OC-related EMT and their underlying mechanisms. Seventy (70) original research articles were identified, as of 23 April 2023. Our review concluded that the dysregulation of lncRNAs is highly associated with EMT-mediated OC progression. A comprehensive understanding of lncRNAs’ mechanisms in OC will help in identifying novel and sensitive biomarkers and therapeutic targets for this malignancy.

Immunohistochemical Study of Ovarian Cancer With Pathological Biomineralization

“…епітеліального до мезенхімального фенотипу. Оскільки пухлинні клітини набувають здатності до інвазивності та міграції через процеси ЕМП, ЕМП є передумовою метастазування [12]. Також метастазування може бути остеотропним за рахунок трансформації між пухлинними клітинами та клітинами кісткової строми, диференціації мезенхімальних стовбурових клітин у остеобласти та остеобласти (клітини остеобластичного фенотипу).…”