The Role of Enamel Matrix Derivative Protein in Minimally Invasive Surgery in Treating Intrabony Defects in Single‐Rooted Teeth: A Randomized Clinical Trial

Ribeiro, Fernanda Vieira; Casarin, Renato Corrêa Viana; Júnior, Francisco Humberto Nociti; Sallum, Enílson Antônio; Casati, Márcio Z.

doi:10.1902/jop.2010.100454

Cited by 50 publications

(96 citation statements)

References 39 publications

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“…() concerning the papilla preservation flap methods (2.48 mm, CI: 1.44–3.52). The present findings are also more favourable with respect to those reported in controlled clinical trials evaluating the outcomes of regenerative surgery in intrabony defects using enamel matrix derivative and minimally invasive surgery (Cortellini & Tonetti, ; Jepsen et al., ; Ribeiro, Casarin, Jùnior, Sallum, & Casati, ). At 12 months they reported CAL changes ranging from 1.8 to 4.9 mm and PD reduction from 2.6 to 5.2 mm.…”

Section: Discussionsupporting

confidence: 74%

Human intrabony defect regeneration with micrografts containing dental pulp stem cells: A randomized controlled clinical trial

Ferrarotti

Romano

Gamba

et al. 2018

J Clinic Periodontology

142

138

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Section: Discussionsupporting

confidence: 74%

Human intrabony defect regeneration with micrografts containing dental pulp stem cells: A randomized controlled clinical trial

Ferrarotti

Romano

Gamba

et al. 2018

J Clinic Periodontology

142

138

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“…Amelogenin, a 20 kDa hydrophobic protein, is the chief ingredient in the EMD. Studies have shown that amelogenin promotes healing and regeneration of the supporting structures of teeth including cementum (3,4). Similar results were reported by Berlucchi et al (5).…”

Section: Introductionsupporting

confidence: 84%

Effect of enamel matrix derivative protein on the healing of standardized epithelial wounds: a histomorphometric analysis in vivo

Al‐Hezaimi

Al‐Askar

Al-Fahad

et al. 2011

International Wound Journal

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The enamel matrix derivative (EMD) is a preparation of the enamel matrix proteins secreted by the Hertwig's epithelial root sheath. It has been shown that EMD promotes periodontal wound healing; however, the significance of the protein in repairing skin wounds is insufficiently addressed. The aim of this in vivo histomorphometric investigation was to analyse the effect of EMD protein on the healing of standardised epithelial wounds. Dorsal skin of 22-week-old female guinea pigs (n = 33) was scarified and divided into test- (topical application of EMD) and control-sites (sutured and allowed to heal). Animals were euthanised at specific time intervals and the specimens were then evaluated histomorphometrically. The mean widths of the external wound gaps (WGs) in the test- and control-sites at the 5th, 20th and 35th day of healing were 5·89, 3·6 and 1·01 mm and 6·41, 5·02 and 3·43 mm, respectively. Histomorphometric analysis showed a statistically significant difference in the WGs between the test- and control-sites. A significant increase in the formation of organised connective tissue matrix, collagen fibres and early muscle formation was observed in the test-sites as compared with the control-sites. Within the limits of this study, it is concluded that topical application of the EMD on standardised epithelial allows early wound closure and promotes healing as compared to when the defects are merely sutured.

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“…In other studies (Cortellini & Tonetti , Ribeiro et al. ,b) comparing M‐MIST with M‐MIST+EMD and MIST with MIST+EMD, no inter‐group significance was reported.…”

Section: Discussionmentioning

confidence: 86%

Efficacy of modified minimally invasive surgical technique in the treatment of human intrabony defects with or without use of rhPDGF‐BB gel – a randomized controlled trial

Mishra¹,

Avula²,

Pathakota³

et al. 2012

J Clinic Periodontology

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The Role of Enamel Matrix Derivative Protein in Minimally Invasive Surgery in Treating Intrabony Defects in Single‐Rooted Teeth: A Randomized Clinical Trial

Abstract: The use of EMD did not provide superior benefits on the outcome of the minimally invasive surgical approach for the treatment of intrabony defects.

Cited by 50 publications

References 39 publications

Human intrabony defect regeneration with micrografts containing dental pulp stem cells: A randomized controlled clinical trial

Human intrabony defect regeneration with micrografts containing dental pulp stem cells: A randomized controlled clinical trial

Effect of enamel matrix derivative protein on the healing of standardized epithelial wounds: a histomorphometric analysis in vivo

Efficacy of modified minimally invasive surgical technique in the treatment of human intrabony defects with or without use of rhPDGF‐BB gel – a randomized controlled trial

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