The role of endobronchial ultrasound-guided transbronchial needle aspiration in isolated intrathoracic lymphadenopathy in non-neoplastic patients: a common dilemma in clinical practice

Santos, Lília Maia; Figueiredo, Vivíane Rossi; Demarzo, Sérgio Eduardo; Palomino, Addy Lidvina Mejía; Jacomelli, Márcia

doi:10.36416/1806-3756/e20180183

Cited by 4 publications

(3 citation statements)

References 18 publications

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“…Screening of granulomas during ROSE enables the bronchoscopist to consider diagnoses related to granulomatous inflammation in the differential diagnosis, which may not have been considered initially. Thus, it can lead to take excessive samples for mycobacterial and fungal smears and cultures 28,29 . In another study we conducted, it was inferred that using PCR in the differentiation of sarcoidosis and TB in cases of granulomatous lymphadenitis increased our diagnosis rate.…”

Section: Discussionmentioning

confidence: 99%

Rapid on‐site evaluation (ROSE) during endobronchial ultrasound bronchoscopy (EBUS) in the diagnosis of granulomatous diseases

Şentürk

Çelik

Altınboğa

2021

Int J Clinical Practice

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Aim We aimed to evaluate the role of Rapid On‐Site Evaluation (ROSE) in improving the diagnostic contribution of EBUS‐guided transbronchial needle aspiration (EBUS‐TBNA) in the diagnosis of granulomatous lymphadenitis. Methods We retrospectively included all patients in the study who underwent EBUS‐TBNA (n = 405) from September 2013 to September 2017. All cases who underwent EBUS‐TBNA and were found to have "granuloma" in the final pathological diagnosis (n = 143) were included in the research. Results One hundred forty‐three cases who underwent EBUS and whose final pathological diagnosis was granuloma were included in the study. A total of 231 lymph nodes were sampled. The final diagnosis was found to be compatible with the examination during the procedure for 55 (85.9%) out of 64 patients for whom ROSE was performed. In addition, while 79.7% of the 64 patients who underwent ROSE were tested positive for granuloma, 9.4% were suspected to have granuloma, and no diagnostic result was obtained for 10.9%. The number of lymph node needle aspirations was statistically significantly lower in patients for whom ROSE was performed (P < .001). The final diagnosis was found to be compatible with the examination during the procedure for 55 (85.9%) out of 64 patients for whom ROSE was performed. According to the evaluation made on the duration, the procedure was completed in the first 15 minutes in 95.4% of the patients for whom ROSE was performed, while the procedure took longer than 15 minutes in 93.6% of the patients for whom ROSE was not performed. Conclusion We found a high incidence of congruence between ROSE and the final cytological diagnosis if granulomas were identified in the final cytology. Performing ROSE shortens the duration of the procedure and reduced sampling thus preventing complications that may occur due to prolongation of the procedure.

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Section: Discussionmentioning

confidence: 99%

Rapid on‐site evaluation (ROSE) during endobronchial ultrasound bronchoscopy (EBUS) in the diagnosis of granulomatous diseases

Şentürk

Çelik

Altınboğa

2021

Int J Clinical Practice

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“…Considering a study conducted with 300 patients in India, the most common etiology in the population was a granulomatous disease such as tuberculosis and sarcoidosis (53%), while malignancy (17%) was found to be the third most frequent in the diagnostic order.Anthracosis caused-lymph node enlargement was reported as another rare etiology encountered in the study (5%) (10). A study from Brasil, granulomatous diseases were found to be common causes of isolated intrathoracic lymphadenopathy in non-neoplastic patients (11). In another study originating from South Asia, tuberculosis appear to be the predominant disease, and sarcoidosis took second place (12).…”

Section: Discussionmentioning

confidence: 99%

Causes of Isolated Mediastinal Lymphadenopathy: Analysis of 348 Patients Undergoing Cervical Mediastinoscopy

Aksoy¹

2022

Erciyes Med J

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“…The two of them are efficient and safe: the diagnostic yield in investigating a generic mediastinal lymphadenopathy has been calculated to be 88% for EUS-FNA and 92% for EBUS-TBNA [ 42 ], with a mortality rate inferior to 1% (0% for EUS-FNA and 0–0.8% for EBUS-TBNA, individually); Santos et al reported a general diagnostic yield for EBUS-TBNA in isolated mediastinal lymphadenopathy of 77.6% [ 43 ]. In addition, the morbidity rate is 0–2.3% for EUS-FNA and 0–1.2% for EBUS-TBNA [ 2 , 42 , 44 ].…”

Section: Studying Mediastinal Lymph Nodesmentioning

confidence: 99%

Role of EBUS-TBNA in Non-Neoplastic Mediastinal Lymphadenopathy: Review of Literature

et al. 2022

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Mediastinal lymphadenopathy is a condition in which one or more mediastinal lymph nodes are enlarged for malignant or benign causes, generally more than 10 mm. For a long time, the only way to approach the mediastinum was surgery, while in last decades endoscopic techniques gained their role in neoplastic diseases. At the present time, EBUS is the technique of choice for studying the mediastinum in the suspicion of cancer, while there are not strong indications in guidelines for the study of benign mediastinal lymphadenopathy. We reviewed the literature, looking for evidence of the role of EBUS in the diagnostics of non-neoplastic mediastinal lymphadenopathy, with special regard for granulomatous disease, both infectious and non-infectious. EBUS is a reliable alternative to surgery in non-neoplastic mediastinal lymphadenopathy, even if more evidence is needed for granulomatous diseases other than tuberculosis and sarcoidosis.

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The role of endobronchial ultrasound-guided transbronchial needle aspiration in isolated intrathoracic lymphadenopathy in non-neoplastic patients: a common dilemma in clinical practice

Cited by 4 publications

References 18 publications

Rapid on‐site evaluation (ROSE) during endobronchial ultrasound bronchoscopy (EBUS) in the diagnosis of granulomatous diseases

Rapid on‐site evaluation (ROSE) during endobronchial ultrasound bronchoscopy (EBUS) in the diagnosis of granulomatous diseases

Causes of Isolated Mediastinal Lymphadenopathy: Analysis of 348 Patients Undergoing Cervical Mediastinoscopy

Role of EBUS-TBNA in Non-Neoplastic Mediastinal Lymphadenopathy: Review of Literature

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