The role of endocrine insulin-like growth factor-I (IGF-I) in female bovine reproduction

Velazquez, Miguel A.; Spicer, L. J.; Wathes, D C

doi:10.1016/j.domaniend.2008.07.002

Cited by 124 publications

(101 citation statements)

References 239 publications

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“…There is evidence in the literature that a high energy deficit followed by high BHBA and NEFA concentrations in the blood and a low IGF-1 level leads to reduced ovarian activity (Butler and Smith, 1989;Ingvartsen et al, 2003;Velazquez et al, 2008;Butler, 2010;Chapinal et al, 2012). These can also be seen in our study.…”

Section: Fertilitysupporting

confidence: 83%

“…In the studies, it is assumed that IGF-1 functions as a mediator between the nutritive status and the reproduction performance (Thissen et al, 1994;Gong, 2002;Zulu et al, 2002a). Therefore, it is guaranteed that the cycle events are not started until the metabolic condition of the cows allows it (Velazquez et al, 2008). Back fat thickness: The reduction of the back fat thickness is an attempt to bypass the time of the NEB.…”

Section: Discussionmentioning

confidence: 99%

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Effects of continuous milking during a field trial on productivity, milk protein yield and health in dairy cows

Köpf

Gellrich

Küchenhoff

et al. 2014

animal

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The objective of this field study with an automatic milking system was to evaluate the effects of omitting the dry period on health and productivity during the subsequent lactation in dairy cows. A total of 98 German Simmental cows of six Southern German farms were assigned randomly to two experimental groups: The first group was dried-off 56 days before calving (D for dried-off, n = 49), and the second group was milked continuously during this period until calving (CM for continuous milking, n = 49). From the latter a third group emerged, including cows that dried-off themselves spontaneously (DS for dried-off spontaneously, n = 14). Blood serum values of glucose, β-hydroxybutyrate (BHBA), non-esterified fatty acids (NEFA) and IGF-1 showed most pronounced fluctuations in D cows. Over the entire study period, the concentrations of BHBA and NEFA were markedly lower in the CM and DS groups. Furthermore, IGF-1 concentration was lowest for D cows and also decrease in back fat thickness was more pronounced. Mean concentration of milk protein was markedly higher in CM and DS cows (3.70% and 3.71%) compared with D cows (3.38%). Owing to the lower 305-day milk yield (−15.6%) and the lower total milk yield (−3.1%), the total amount of produced protein in the subsequent lactation was 2.5% (6.8 kg) lower, although the additional protein amount in CM cows from week −8 to calving was 35.7 kg. The greatest benefit resulted from positive effects on fertility and the lower incidence of diseases: CM cows had their first oestrus 1 week earlier compared with D cows, they also conceived earlier and showed a significantly lower risk of developing hypocalcaemia, ketosis and puerperal disorders. The present study showed that the costs of medical treatment and milk losses were twice as high in D cows, compared with CM and DS cows, and thus the reduced costs because of the more stable health outweighed the financial losses of milk yield by + 18.49 € per cow and lactation.

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Section: Fertilitysupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Effects of continuous milking during a field trial on productivity, milk protein yield and health in dairy cows

Köpf

Gellrich

Küchenhoff

et al. 2014

animal

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“…Insulin regulates the expression of IGF binding proteins (IGFBPs) which are responsible for the bioavailability of IGFs (Royal et al 2000). IGFBPs are expressed in the pre-ovulatory follicles as well as in the oviduct and endometrium (Armstrong et al 2002;Velazquez et al 2008;Wathes et al 1998).…”

Section: Introductionmentioning

confidence: 99%

Characterisation of endometrial gene expression and metabolic parameters in beef heifers yielding viable or non-viable embryos on Day 7 after insemination

Beltman

Forde

Furney

et al. 2010

Reprod. Fertil. Dev.

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Abridged title: Endometrial gene expression and metabolic parameters in subfertile beef heifers. AbstractThe objective of this study was to compare the hormonal, metabolic characteristics and endometrial gene expression profiles in beef heifers yielding either a viable or a degenerate embryo on Day 7 after insemination as a means to explain differences in embryo survival.Oestrus was synchronised in cross bred beef heifers (n=145) using a CIDR-prostaglandin protocol and heifers (n=102) detected in standing oestrus (within 24-48 h post CIDR removal) were inseminated 12-18 h after detection of oestrus (Day 0) with frozen-thawed semen from a single ejaculate of a bull with proven fertility. Blood samples were collected from Day 4 to Day 7 post oestrus to measure progesterone (on Days 4, 5 and 7), insulin and IGF-I (on Days 4 and 6) and urea concentrations (on Day 7). All animals were slaughtered on Day 7. Uterine pH was also determined. Animals from which an embryo was recovered were classified as either having a viable embryo (morula/blastocyst stage); n=32, or a retarded embryo (arrested at 2-to 16-cell stage); n=19. The overall recovery rate was 64%. There was no significant difference in blood parameters measured or uterine pH at slaughter between the heifers with either a viable or retarded embryo. The relative abundance of 9 transcripts out of 53 tested from the endometrial tissue was different between heifers with a viable embryo or retarded embryo: MOGAT1, PFKB2, LYZ2, SVS8, UHRF1, PTGES, AGPAT4, DGKA and HGPD. Both LYZ2 and UHRF1 are associated with regulation of the immune system. PFKFB2 is a mediator in glycolysis and MOGAT, AGPAT4 and DGKA belong to the triglyceride synthesis pathway. PTGES and HGPD belong to the prostaglandin pathway.Both of these metabolic pathways are important for early embryonic development. In conclusion, retarded embryo development in this study was not related to serum progesterone, IGF-I, insulin or urea concentrations nor to uterine pH at slaughter. However, altered expression of genes involved in the prostaglandin and triglyceride pathways, as well as 2 genes that are closely associated with the regulation of immunity in the endometrium may indicate a uterine component to the retardation of the embryos in these beef heifers.

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“…In addition, IGF-I can influence on the proliferation and differentiation of granulosa cell, postpartum follicular growth and consequently first ovulation of the dominant follicle, development of corpus luteum and preimplantation embryo development [6,7] . Correspondingly, a positive relationship has been reported between reproductive performance and the concentration of IGF-I after calving in dairy cows [8,9] .…”

Section: Introductionmentioning

confidence: 76%

The effect of polymorphism in gene of insulin-like growth factor-I on the serum periparturient concentration in Holstein dairy cows

Mirzaei

Sharifiyazdi

Ahmadi

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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The role of endocrine insulin-like growth factor-I (IGF-I) in female bovine reproduction

Cited by 124 publications

References 239 publications

Effects of continuous milking during a field trial on productivity, milk protein yield and health in dairy cows

Effects of continuous milking during a field trial on productivity, milk protein yield and health in dairy cows

Characterisation of endometrial gene expression and metabolic parameters in beef heifers yielding viable or non-viable embryos on Day 7 after insemination

The effect of polymorphism in gene of insulin-like growth factor-I on the serum periparturient concentration in Holstein dairy cows

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