The role of endoscopic ultrasound in a case of lung cancer with jaundice

Castro-Poças, Fernando; Araújo, Tarcísio; Ferreira, Maria do Céu; Saraiva, Miguel Mascarenhas

doi:10.4103/2303-9027.193570

Cited by 5 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Small cell lung cancer presents initially with increased serum bilirubin in about 10% of cases, caused by hepatic (6%) or pancreatic (4%) metastases[ 94 ]. Obstructive jaundice due to hilar lymph node compression from metastatic small cell lung carcinoma has also been reported[ 95 ]. Most reports of metastasis-induced acute pancreatitis come from small cell lung cancer or gastric cancer metastasizing to the pancreatic head, with isolated reports of squamous cell lung cancer, adrenocortical carcinoma, and breast cancer[ 96 - 99 ].…”

Section: Primary Malignanciesmentioning

confidence: 99%

Malignant biliary obstruction due to metastatic non-hepato-pancreato-biliary cancer

Okamoto¹

2022

WJG

View full text Add to dashboard Cite

Malignant biliary obstruction generally results from primary malignancies of the pancreatic head, bile duct, gallbladder, liver, and ampulla of Vater. Metastatic lesions from other primaries to these organs or nearby lymph nodes are rarer causes of biliary obstruction. The most common primaries include renal cancer, lung cancer, gastric cancer, colorectal cancer, breast cancer, lymphoma, and melanoma. They may be difficult to differentiate from primary hepato-pancreato-biliary cancer based on imaging studies, or even on biopsy. There is also no consensus on the optimal method of treatment, including the feasibility and effectiveness of endoscopic intervention or surgery. A thorough review of the literature on pancreato-biliary metastases and malignant biliary obstruction due to metastatic non-hepato-pancreato-biliary cancer is presented. The diagnostic modality and clinical characteristics may differ significantly depending on the type of primary cancer. Different primaries also cause malignant biliary obstruction in different ways, including direct invasion, pancreatic or biliary metastasis, hilar lymph node metastasis, liver metastasis, and peritoneal carcinomatosis. Metastasectomy may hold promise for some types of pancreato-biliary metastases. This review aims to elucidate the current knowledge in this area, which has received sparse attention in the past. The aging population, advances in diagnostic imaging, and improved treatment options may lead to an increase in these rare occurrences going forward.

show abstract

Section: Primary Malignanciesmentioning

confidence: 99%

Malignant biliary obstruction due to metastatic non-hepato-pancreato-biliary cancer

Okamoto¹

2022

WJG

View full text Add to dashboard Cite

show abstract

“…In addition, contrast-enhanced ultrasound increased the diagnostic rate via observation of microvessel density and vascular endothelial growth factor expression, which may be valuable in the evaluation of early-stage breast cancer (17). In addition, microbubble ultrasound contrast agent has been reported to enhance the diagnostic rate for patients with suspected lung cancer in clinical settings (18,19). These reports suggested that microbubble ultrasound contrast not only increases reflected signal, but also improves the diagnostic rate for patients with suspected lung cancer in the clinic.…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic diagnosis combined with targeted ultrasound contrast agent improves diagnostic sensitivity of ultrasonic for non‑small cell lung cancer patients

Zhang

Chu

2018

Exp Ther Med

View full text Add to dashboard Cite

Non-small cell lung cancer (NSCLC) is one of the most prevalent human cancers, which is known for local growth, easily migration, long-distance invasion and reoccurrence. Targeted ultrasound (US) contrast combined with ultrasound for lung cancer diagnosis has been applied in the clinic. In the present study, a novel targeted ultrasound contrast agent containing chistosan/FeO-parceled bispecific antibody (TcBab) targeting carcino-embryonic antigen, vascular endothelial growth factor receptor was introduced, and the diagnostic accuracy and sensitivity was investigated in patients with NSCLC. A total of 384 patients with suspected NSCLC were recruited to investigate the accuracy of TcBab-ultrasound (TcBab-US) and ultrasound. Results demonstrated that TcBab-US improved sensitivity and may provide a novel protocol for diagnosing tumors in patients with suspected NSCLC at an early stage. Data analysis demonstrated that TcBab-US diagnosed 154 suspected patients with NSCLC, whereas ultrasound only diagnosed 84 suspected patients with NSCLC out of a total of 384 patients with suspected NSCLC (P<0.01). A dosage experiment revealed that the optimal dose of TcBab was 5 mg/kg for NSCLC patients. Pharmacodynamics analysis showed that TcBab may be metabolized within 16 h in serum of patients. Notably, early diagnosis determined by TcBab-US contributed to improvement of survival for NSCLC patients as determined by a comparison of the survival rate with the survival rate of patients who did not receive TcBab (P<0.05). In conclusion, these investigations suggested that TcBab improves the accuracy and diagnostic confidence of ultrasonic for the diagnosis of early-stage NSCLC, and may have potential application value in the clinic.

show abstract

The expression of miRNA-216b is negatively correlated with 18F-FDG uptake in non-small cell lung cancer

et al. 2021

View full text Add to dashboard Cite

Background This study aimed to investigate the correlation between miRNA-216b expression in patients with non-small cell lung cancer (NSCLC) and 18F-fluorodeoxyglucose (FDG) uptake by PET/CT and to explore the clinical application value of 18F-FDG PET/CT in miRNA-216b based on therapy for NSCLC. Methods Eighty patients with NSCLC and 40 healthy subjects were enrolled in our study. The SUVmax of the lesion area by PET/CT imaging was calculated. SUVmax represented the highest concentration of 18F-FDG in the lesion. The expression of miRNA-216b in the plasma and fiber bronchoscopic puncture of NSCLC patients was detected by RT qPCR. Then Pearson correlation analysis was used to analyze the correlation between miRNA-216b expression and 18F-FDG uptake in patients with different types of NSCLC. Results Compared with healthy subjects, SUVmax of early adenocarcinoma and advanced adenocarcinoma were increased. Compared with healthy subjects, SUVmax of early squamous and advanced squamous were increased. And the SUVmax content of advanced adenocarcinoma and squamous cell carcinoma was higher than that of early adenocarcinoma and squamous cell carcinoma. Compared with healthy subjects, the expression of miRNA-216b in the plasma of patients with early and advanced adenocarcinoma was reduced, and the expression of miRNA-216b in the plasma of patients with early and advanced squamous cell carcinoma was reduced. Compared with adjacent tissues, the expression of miRNA-216b in early adenocarcinoma tissues and advanced adenocarcinoma tissues was reduced, and the expression in early squamous cell carcinoma and advanced squamous cell carcinoma was reduced. Pearson correlation analysis showed a negative correlation between SUVmax and miRNA-216b (plasma and tissue) in patients with four types of NSCLC. Conclusion miRNA-216b expression was negatively correlated with 18F-FDG uptake in NSCLC. miRNA-216b could be used for the classification and staging of non-small cell lung cancer. 18F-FDG PET/CT may be used to evaluate the therapeutic response in application of miRNA-216b-based cancer treatment.

show abstract

The role of endoscopic ultrasound in a case of lung cancer with jaundice

Cited by 5 publications

References 8 publications

Malignant biliary obstruction due to metastatic non-hepato-pancreato-biliary cancer

Malignant biliary obstruction due to metastatic non-hepato-pancreato-biliary cancer

Ultrasonic diagnosis combined with targeted ultrasound contrast agent improves diagnostic sensitivity of ultrasonic for non‑small cell lung cancer patients

The expression of miRNA-216b is negatively correlated with 18F-FDG uptake in non-small cell lung cancer

Contact Info

Product

Resources

About