The Role of Endoscopy in Portal Hypertension

Biecker, Erwin; Schepke, Michael; Sauerbruch, Tilman

doi:10.1159/000084721

Cited by 9 publications

(3 citation statements)

References 71 publications

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“…There is no significant difference between the two groups regarding demographic data or child classification. The pulmonary functions before & one day after injection sclerotherapy were illustrated -in the same arrangement-in table (2). Vital capacity (VC) was 4.24 ±0.39 liters before and 3.89 ±0.08 liters after therapy (P ˂0.05).…”

Section: Discussionmentioning

confidence: 99%

“…They are most often a consequence of portal hypertension, commonly due to cirrhosis and one of the common causes of upper gastrointestinal bleeding. Diagnosis of variceal bleeding or risk of bleeding is done by upper gastrointestinal endoscopy [2]. Variceal bleeding is a major complication of portal hypertension and represents a leading cause of death in patients with cirrhosis.…”

Section: Introductionmentioning

confidence: 99%

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Pulmonary Functions After Injection Sclerotherapy Of Esophageal Varices & After Band Ligation

Metwally

Moawad

Ali

2013

The Egyptian Journal of Hospital Medicine

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Aim of the study:To study changes in pulmonary function tests after esophageal variceal injection sclerotherapy in comparison to changes after esophageal variceal band ligation. Patients & methods:This study was designed as non randomized controlled study. Thirty patients with hepatic cirrhosis & portal hypertension who were admitted to Hepatology, Gastroenterology and Infectious Diseases department , Benha university hospital for elective esophageal variceal therapy (secondary prophylaxis) were classified into group I:15 patients treated with sclerotherapy by using 5-15 ml ethanolamine oleate and group II:15 patients treated with band ligation. Patients were subjected for full clinical evaluation including history, general, chest, and abdominal examination. Laboratory and radiological investigation including complete blood count, liver function tests, kidney function tests and blood sugar and plain chest x-ray (P.A. and lateral views) were done. Pulmonary function tests and arterial blood gasses were done before, one day after and one week after the procedure. Results:The results revealed , significant decrease in vital capacity in group I one day after injection ( p ˂ 0.05),but no significant decrease in vital capacity in group II. There was a significant decrease in PaO2 in group I one day after injection sclerotherapy ( p ˂ 0.05) but no significant changes in group II and no significant changes in PaCO2 in both groups one day after the procedures. The study has also revealed no significant changes in FVC,FEV1/FVC and PaCO2 in group I and group II after procedures. The study revealed significant linear correlation between the decreases in PaO2 and the percentage decrease in vital capacity( p ˂ 0.05). One week after procedure, pulmonary functions that has been affected in group I returned back to baseline values. Conclusions: esophageal injection sclerotherapy produces restrictive defect (decrease in PaO2 and vital capacity) in pulmonary functions one day after injection and improved within one week, while there was no effect for band ligation on pulmonary functions tests.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pulmonary Functions After Injection Sclerotherapy Of Esophageal Varices & After Band Ligation

Metwally

Moawad

Ali

2013

The Egyptian Journal of Hospital Medicine

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“…They are most often a consequence of portal hypertension, commonly due to cirrhosis. OV are typically diagnosed through an esophagogastroduodenoscopy [2].…”

Section: Introductionmentioning

confidence: 99%

Immature Platelet Fraction as a Non-Invasive Marker for Esophageal Varices

Soliman

Abd‐Elsalam

Al-Bendary

et al. 2021

JAMMR

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Background: All cirrhotic patients should be screened for oesophageal varices (OV) at the time of diagnosis. The development of a non-invasive method for the detection of OV is a vital issue in subjects with cirrhosis to decrease the need for invasive endoscopic procedures that can be costly. This work aimed to evaluate immature platelet fraction (IPF) as a non-invasive marker and predictor of OV. Methods: This cross-sectional study was carried out on 80 cirrhotic patients with esophageal varices diagnosed by upper endoscopy. They were divided into Group (1): 40 patients with cirrhosis with esophageal varices and Group (2): 40 patients with cirrhosis and without esophageal varices. All patients were subjected to the complete history taking, physical examination, routine laboratory investigations (Complete blood count, IPF, C-reactive protein, Liver and kidney function tests, Bone marrow aspiration for some cases, Ascetic sample analysis when applicable), Pelvic-Abdominal ultrasonography, Child Pugh score assessment, Upper GIT endoscopy. Results: There was a significant difference between the studied groups regarding IPF (p<0.001). At cutoff >12 IPF had (AUC= 0.993) with sensitivity of 97.5% and specificity of 97.5% for detection of esophageal varices. There was a significant negative correlation between IPF and platelets count (p- value < 0.001). There was a significant positive correlation between IPF and Child Pugh score (p- value <0.001). There was a highly significant positive correlation between IPF and CRP (p value <0.001). There was significant difference between the two groups as regards splenic longitudinal diameter (p<0.001). As regards platelet count, there was a significant difference between the two groups (p<0.001). It was significantly lower in Group 1. Conclusions: IPF is elevated in cirrhotic patients with naive esophageal varices than in cirrhotic patients without varices. IPF could be used as a noninvasive, easy to measure method for detection of the presence of esophageal varices at a cutoff level of >12.

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Laparoscopic splenectomy plus preoperative endoscopic variceal ligation versus splenectomy with pericardial devascularization (Hassab’s operation) for control of severe varices due to portal hypertension

Zhou

et al. 2013

Surg Endosc

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The Role of Endoscopy in Portal Hypertension

Cited by 9 publications

References 71 publications

Pulmonary Functions After Injection Sclerotherapy Of Esophageal Varices & After Band Ligation

Pulmonary Functions After Injection Sclerotherapy Of Esophageal Varices & After Band Ligation

Immature Platelet Fraction as a Non-Invasive Marker for Esophageal Varices

Laparoscopic splenectomy plus preoperative endoscopic variceal ligation versus splenectomy with pericardial devascularization (Hassab’s operation) for control of severe varices due to portal hypertension

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