2015
DOI: 10.1016/j.mehy.2015.03.007
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The role of endothelial dysfunction driven by adipocitokines in the development and progression of microvascular complications in patients with type 1 and type 2 diabetes

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Cited by 8 publications
(6 citation statements)
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“…The foveal avascular zone (FAZ) in healthy eyes is an area delineated by a combination of superficial capillaries, deep capillaries, and is typically round or oval in healthy individuals. The measured area is generally proportional to age [20] , usually between 0.231 and 0.280 mm [21] . Quantitative parameters such as FAZ area, roundness, and stratified vessel density could be obtained by OCTA scanning.…”
Section: Discussionmentioning
confidence: 99%
“…The foveal avascular zone (FAZ) in healthy eyes is an area delineated by a combination of superficial capillaries, deep capillaries, and is typically round or oval in healthy individuals. The measured area is generally proportional to age [20] , usually between 0.231 and 0.280 mm [21] . Quantitative parameters such as FAZ area, roundness, and stratified vessel density could be obtained by OCTA scanning.…”
Section: Discussionmentioning
confidence: 99%
“…Resistin is an adipokine produced mainly in rodent adipocytes and in monocytes and macrophages in humans (Kaser, et al, 2003). Elevated serum levels of resistin are associated with metabolic disorders and diabetic microvascular complications mediated by endothelial dysfunction (Blaslov, et al, 2015). Interestingly, obesity is still observed in mice with resistin deficiency, despite improved glucose tolerance and insulin sensitivity (Banerjee, et, al., 2004).…”
Section: Proinflammatory Adipokinesmentioning
confidence: 99%
“…Insulin resistance, diabetes & obesity [11][12][13], rheumatoid arthritis [70], psoriasis [95], SLE [87], atherosclerosis [147] Systemic sclerosis with PAH [82], increased appetite [126] PAI- Alzheimer's [120] Insulin resistance &diabetes [11,12], hyperlipidemia [25], kidney failure [27,28], gestational diabetes [40], IVDD [48], rheumatoid arthritis& osteoarthritis [47,58], systemic sclerosis complications: PAH, DVT, PE, digital ulcers [76,77], SLE with renal involvement [87], psoriasis [92], Alzheimer's [118], major depression & bipolar [122,123], NAFLD&NASH [125], diabetic microvascular complications [154], atherosclerosis and cardiovascular disease [155], sepsis [162], acute pancreatitis [163]…”
Section: • Preeclampsiamentioning
confidence: 99%
“…On the other side, elevated serum levels of resistin are associated with diabetic microvascular complications mediated by its role in causing endothelial dysfunction [154], besides, it has a significant role in atherosclerosis and cardiovascular disease occurrence [155]; this is explained as resistin mediates different molecular pathways e.g. angiogenesis, thrombosis migration, proliferation of the vascular smooth muscle cells and increasing MCP-1 and sVCAM-1 (soluble vascular cell adhesion molecule-1) expression in vascular endothelial cells [40].…”
Section: • Other Vesselsmentioning
confidence: 99%