The role of endothelial progenitor cells in transient ischemic attack patients for future cerebrovascular events

Meamar, Rokhsareh; Nikyar, Hamidreza; Dehghani, Leila; Talebi, Maedeh; Dehghani, Marzieh; Ghasemi, Marzieh; Ansari, Behnaz; Saadatnia, Mohammad

doi:10.4103/1735-1995.183995

Cited by 12 publications

(11 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is probably the mechanism of differentiation into mature endothelial cells, which, due to the production of numerous cytokines, are actively involved in the repair and neovascularization of damaged brain tissues [ 7 ]. Similar conclusions were drawn by Yip et al, Meamar et al, and Regueiro et al [ 20 , 21 , 22 ], who, assessing patients in the acute phase of ischemic stroke, also found a significantly higher number of EPCs than in control. Similarly, Paczkowska et al [ 23 ] obtained a higher number of EPCs in the acute stage of hemorrhagic stroke in comparison to the control group.…”

Section: Discussionsupporting

confidence: 88%

Endothelial Progenitor Cells as a Marker of Vascular Damage But not a Predictor in Acute Microangiopathy-Associated Stroke

Wiśniewski

Boińska

Ziółkowska

et al. 2020

JCM

View full text Add to dashboard Cite

Background: The aim of the study was to assess the number of endothelial progenitor cells (EPCs) in patients with acute stroke due to cerebral microangiopathy and evaluate whether there is a relationship between their number and clinical status, radiological findings, risk factors, selected biochemical parameters, and prognosis, both in ischemic and hemorrhagic stroke. Methods: In total, 66 patients with lacunar ischemic stroke, 38 patients with typical location hemorrhagic stroke, and 22 subjects from the control group without acute cerebrovascular incidents were included in the prospective observational study. The number of EPCs was determined in serum on the first and eighth day after stroke onset using flow cytometry and identified with the immune-phenotype classification determinant (CD)45−, CD34+, CD133+. Results: We demonstrated a significantly higher number of EPCs on the first day of stroke compared to the control group (med. 17.75 cells/µL (0–488 cells/µL) vs. 5.24 cells/µL (0–95 cells/µL); p = 0.0006). We did not find a relationship between the number of EPCs in the acute phase of stroke and the biochemical parameters, vascular risk factors, or clinical condition. In females, the higher number of EPCs on the first day of stroke is related to a favorable functional outcome on the eighth day after the stroke onset compared to males (p = 0.0355). We found that a higher volume of the hemorrhagic focus on the first day was correlated with a lower number of EPCs on the first day (correlation coefficient (R) = −0.3378, p = 0.0471), and a higher number of EPCs on the first day of the hemorrhagic stroke was correlated with a lower degree of regression of the hemorrhagic focus (R = −0.3896, p = 0.0367). Conclusion: The study showed that endothelial progenitor cells are an early marker in acute microangiopathy-associated stroke regardless of etiology and may affect the radiological findings in hemorrhagic stroke. Nevertheless, their prognostic value remains doubtful in stroke patients.

show abstract

Section: Discussionsupporting

confidence: 88%

Endothelial Progenitor Cells as a Marker of Vascular Damage But not a Predictor in Acute Microangiopathy-Associated Stroke

Wiśniewski

Boińska

Ziółkowska

et al. 2020

JCM

View full text Add to dashboard Cite

show abstract

“…Neural stem/precursor cells (NSCs) are utilized as a part of biomedical application to treat neuronal sicknesses by infusing the exogenous NSCs in animal models . The NSCs have been infused in the lateral ventricle, and appeared to recuperate from brain ischemia .…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…PAI provides excellent optical absorption as results from the determination of ultrasound for profound tissue/organ imaging. In the graphene family nanomaterials, rGO assumes an essential part as PA differentiation specialists, on the grounds that rGOs with bigger sp 2 spaces than GOs can ingest NIR light more effectively. In any case, the hydrophilicity of GOs is diminished after the reduction, prompting poor water solvency of rGOs.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Graphene and Graphene‐Based Materials in Biomedical Science

Swetha

Manisha

Prasad

2018

Part & Part Syst Charact

View full text Add to dashboard Cite

Graphene and its composite materials are very important in many disciplines of science and have been used enormously by researchers since their discovery in 2004. These are a new group of compounds, and are also wonderful model systems for quantum behavior studies. Their properties like exceptional conductivity, biocompatibility, surface area, mechanical strength, and thermal properties make them rising stars in the scientific community. Graphene and its composite compounds are utilized widely in different medical applications, for example, biosensing of biological compounds responsible for disease development, bioimaging of various cells, tissues, microorganisms, animal models, etc. In addition, they are used for enhancing and supporting the stem cell differentiation, i.e., regenerative medicine for regeneration studies of various human organs, tissue engineering in biology for the development of carrier materials, as well as in bone reformation. This review focuses on the modification procedure involved in the fabrication of graphene‐based biomaterials for various applications and recent developments in research related to graphene and graphene‐based materials in biosensing, optical sensing, gas sensing, drug, gene, protein delivery, tissue engineering, and bioimaging. In addition, the potential toxicological effects of graphene‐based biomaterials are discussed.

show abstract

“…In a previous study, increased circulatory EPC levels were detected in the first TIA attack as compared to the control. However, this failed to increase the incidence of cerebrovascular disease and the level of EPC was not considered as a predictive factor in the study population (11). This study aimed to find the role of TIA risk factors in the level of these cells.…”

Section: Discussionmentioning

confidence: 98%

Evaluation of related variables on endothelial progenitor cells in first transient ischemic attack

Meamr

Nikyar

Chitsaz

et al. 2019

J Shahrekord Univ Med Sci

Self Cite

View full text Add to dashboard Cite

Background and aims: In a transient ischemic attack (TIA), the activation of the endothelial progenitor cells (EPCs) has a prominent role in the formation of collateral vessels. The aim of this study was to evaluate the role of effective variables (e.g., hypertension, diabetes, hyperlipidemia, cardiovascular diseases, a family history of cardiovascular diseases, and statin therapy on the level of EPCs in TIA. Methods: Thirty patients suffering from the first attack of TIA, without having a history of acute cerebral injury, surgery or trauma, and blood disorders were enrolled in this cross-sectional study. Then, flow cytometry was utilized to estimate the level of EPCs CD34 and CD309 and the results were evaluated based on the t test or the Mann-Whitney test. Finally, the Pearson or Spearman correlation was used to establish the relationship between the variables. The level of P<0.05 was considered statistically significant in this study. Results: The mean±SD number of CD309 in patients with hyperlipidemia was less than those with no hyperlipidemia (3.35±2.77 vs. 5.59±3.85, P=0.02) and diabetic patients had a significantly higher number of CD309 compared to non-diabetics (6.14±4.89 vs, 3.5± 3.49, P=0.05). Conversely, the mean number of CD34 in groups with or without the studied variables was not statistically significant. The results further revealed that the average total of CD309 and CD34 was significantly lower in patients with hyperlipidemia as compared to those with no sign of hyperlipidemia (9.44± 3.05 vs. 6.67±4.6, P=0.02). Using logistic regression, the intended variables demonstrated no significant effects on endothelial cells, and the relationship between age and the number of progenitor cells was not significant. Conclusion: In our study, only hyperlipidemia acted as a factor influencing the numbers of EPCs. Therefore, more studies with larger sample sizes are required to discover the role of these variables on progenitor cells in TIA.

show abstract

The role of endothelial progenitor cells in transient ischemic attack patients for future cerebrovascular events

Cited by 12 publications

References 29 publications

Endothelial Progenitor Cells as a Marker of Vascular Damage But not a Predictor in Acute Microangiopathy-Associated Stroke

Endothelial Progenitor Cells as a Marker of Vascular Damage But not a Predictor in Acute Microangiopathy-Associated Stroke

Graphene and Graphene‐Based Materials in Biomedical Science

Evaluation of related variables on endothelial progenitor cells in first transient ischemic attack

Contact Info

Product

Resources

About