The role of environmental factors in insulin-dependent diabetes mellitus: an unresolved issue.

Kraine, Meredith R.; Tisch, Roland

doi:10.1289/ehp.99107s5777

Cited by 16 publications

(4 citation statements)

References 47 publications

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“…Diabetes-induced impairment of lymphocyte function has also been suggested previously [ 16 ]. Consequently, these results can explain the impaired immune system and enhanced susceptibility to infections in a poorly controlled diabetic state [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Decreased Level of Albumin in Peripheral Blood Mononuclear Cells of Streptozotocin-Induced Diabetic Rats

et al. 2014

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We investigated the phenotypic level of albumin in peripheral blood mononuclear cells (PBMC) of streptozotocin (STZ)-induced diabetic rats. A specific reduction of albumin was identified by 2-dimensional electrophoresis and mass spectrometry. Decreased albumin content was also confirmed by immunoblotting and quantitative real-time PCR. Since albumin is a major and predominant antioxidant in plasma, the PBMC albumin may also contribute to their antioxidant activity. By measuring the amount of H2O2, lipid peroxidation and the redox form of glutathione, it was found that the production of the oxidative stress was elevated in STZ-diabetic rats compared to that of normal control. We suggest, therefore, that decreased albumin content may lead to the decreased antioxidant activity in the PBMC of type 1 diabetic rats.

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Section: Discussionmentioning

confidence: 99%

Decreased Level of Albumin in Peripheral Blood Mononuclear Cells of Streptozotocin-Induced Diabetic Rats

et al. 2014

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“…When the pathogenesis of type 2 diabetes is classified into two stages, insulin resistance and insulin secretory defects, the latter part seems to be more important among elderly people ( 10 ). Indeed, it is well known that many chemicals, including streptozotocin, alloxan, and vacor, can induce β-cell destruction ( 19 ). Although there has been no experimental study on the effects of POPs on pancreatic β-cells, one experimental study ( 9 ) observed alterations in mitochondrial function and oxidative capacity in the liver of rats exposed to a mixture of POPs.…”

Section: Discussionmentioning

confidence: 99%

Polychlorinated Biphenyls and Organochlorine Pesticides in Plasma Predict Development of Type 2 Diabetes in the Elderly

et al. 2011

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OBJECTIVEPersistent organic pollutants (POPs), lipophilic chemicals that accumulate mainly in adipose tissue, have recently been linked to type 2 diabetes. However, evidence from prospective studies is sparse. This study was performed to evaluate prospective associations of type 2 diabetes with selected POPs among the elderly.RESEARCH DESIGN AND METHODSNineteen POPs (14 polychlorinated biphenyl [PCB] congeners, 3 organochlorine pesticides, 1 brominated diphenyl ether, and 1 dioxin) were measured in plasma collected at baseline in 725 participants, aged 70 years, of the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS).RESULTSAfter adjusting for known type 2 diabetes risk factors, including obesity, odds ratios (ORs) (95% CIs) for type 2 diabetes at age 75 years (n = 36) according to the quintiles of a summary measure of concentrations of PCBs (vs. the lowest quintile) were 4.5, 5.1, 8.8 (1.8–42.7), and 7.5 (1.4–38.8) (Ptrend <0.01). Among organochlorine pesticides, adjusted ORs across concentrations of trans-nonachlor showed that Ptrend = 0.03. Adjusted ORs (95% CIs) across quintiles of the sum of three organochlorine pesticides were 1.1, 1.6, 1.5, and 3.4 (1.0–11.7) (Ptrend = 0.03). Neither brominated diphenyl ether 47 nor dioxin was significantly associated with incident diabetes. The sum of PCBs improved reclassification significantly when added to traditional risk factors for diabetes.CONCLUSIONSDespite the small number of incident cases, this study found that environmental exposure to some POPs substantially increased risk of future type 2 diabetes in an elderly population.

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“…They require glucose as a primary fuel source and strict regulation of glucose is required to maintain immune homeostasis. Impairment of glucose transport in splenocytes and thymocytes and its regulation by insulin is a common feature of human diabetes, enhancing susceptibility to infections [ 9 ]. Although the reason for increased susceptibility of diabetic patients to persistent infections is not fully understood, the administration of insulin restores some of the altered functions of diabetic lymphocytes [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…In this way many factors such as metabolic requirements, hormones and external signals modify their glucose consumption [ 8 ]. The study of glucose transport in lymphocytes and its regulation by insulin is important in the MS, since the exacerbated immune response participates in physiological and pathological conditions of diabetes mellitus type II (T2DM), which is an important component of this syndrome [ 9 ]. The reason for the increased susceptibility of diabetic patients to persistent infections is not fully understood, but it is known that sepsis or infection, as in diabetic ulcers, raises cytokine secretion, which exacerbates damage, produces insulin resistance and diminishes lymphocyte proliferation.…”

Section: Introductionmentioning

confidence: 99%

Insulin effect on glucose transport in thymocytes and splenocytes from rats with metabolic syndrome

Carbó

Guarner

2010

Diabetol Metab Syndr

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Metabolic syndrome (MS) may comprise several clinical conditions such as obesity, diabetes and inflammatory disorders, which are characterized by metabolic imbalances. The study of glucose transport and regulation by insulin in lymphocytes is important, since the way they increase inflammation and susceptibility to infections are common in MS. We studied glucose internalization in isolated thymocytes and splenocytes, its regulation by insulin, and the role of three glucose transporters (Gluts) in control and in MS rats. Control glucose internalization and insulin responses were lower in splenocytes than in thymocytes. Control and insulin-induced glucose internalization in thymocytes declined with age, while transport by splenocyte continued to respond to insulin. Control thymocyte glucose internalization was blocked by antibodies against Glut 1 and 4, while the insulin response also was blocked by an anti-Glut 3 antibody. On four month old control and insulin-induced response, splenocyte transport was only blocked by Glut 1 and 4 antibodies. At six months splenocyte glucose internalization depended on Glut 1 and was less sensitive to the effects of an anti-Glut 4 antibody. In MS splenocytes the capacity of anti-Glut 1 antibodies to inhibit control and insulin-dependent glucose transport was less significant, and we found that in MS rats, glucose internalization was dependent on Glut 3 and Glut 4. In summary, the altered metabolic state present in MS rats shows signs of modulation of glucose internalization by the Glut1, Glut 3 and Glut 4 transporters, compared with its own age control.

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The role of environmental factors in insulin-dependent diabetes mellitus: an unresolved issue.

Cited by 16 publications

References 47 publications

Decreased Level of Albumin in Peripheral Blood Mononuclear Cells of Streptozotocin-Induced Diabetic Rats

Decreased Level of Albumin in Peripheral Blood Mononuclear Cells of Streptozotocin-Induced Diabetic Rats

Polychlorinated Biphenyls and Organochlorine Pesticides in Plasma Predict Development of Type 2 Diabetes in the Elderly

Insulin effect on glucose transport in thymocytes and splenocytes from rats with metabolic syndrome

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