The role of epidural spinal cord stimulation in the treatment of Buerger’s disease

Donas, Konstantinos P.; Schulte, Stefan; Ktenidis, Kiriakos; Hörsch, S.

doi:10.1016/j.jvs.2005.01.044

Cited by 69 publications

(51 citation statements)

References 35 publications

(40 reference statements)

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“…10 More recently, the use of spinal cord stimulation (SCS) for symptoms alleviation and ulcer healing has been suggested. 11,12 In addition to the aforementioned therapeutic approaches, there has been increasing interest in the use of angiogenesis in patients with TAO, with preliminary studies demonstrating collateral blood vessel formation associated with clinical improvement. [13][14][15] For more serious patients with TAO having severe ischemia and risk of limb amputation, surgical or percutaneous revascularisation approach (PTA), when technically feasible, could be considered.…”

Section: Introductionmentioning

confidence: 99%

Noninvasive Transcutaneous Monitoring in Long-Term Follow-Up of Patients With Thromboangiitis Obliterans Treated With Intravenous Iloprost

et al. 2014

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We evaluated the effectiveness of intravenous iloprost (IVI) in outpatients with thromboangiitis obliterans (TAO) and lower limb noninvasive transcutaneous monitoring (TCM) at follow-up (FU). Ten consecutive patients with TAO underwent IVI therapy. Transcutaneous oxygen (TcPO 2 ) and carbon dioxide (TcPCO 2 ) determination and laser Doppler flowmetry (LDF) were performed before and after IVI at 3, 6, and 12 months of FU. Clinical response was positive in 7 patients, whereas 3 nonresponders underwent a second IVI cycle with 1 showing a late positive clinical response. After 12 months of FU, all patients were alive without amputations. Supine and dependent TcP 2 levels significantly improved (P < .005). Hallux LDF values showed significant change with the maximal hyperemic test at 44 C (P < .005). Forefoot maximal hyperemic test at 44 C LDF (P < .005) and improved venous arterial reflex (P < .05) showed statistically significant time evolution. We demonstrated some degree of IVI effectiveness and evaluated TCM in patients with TAO.

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Section: Introductionmentioning

confidence: 99%

Noninvasive Transcutaneous Monitoring in Long-Term Follow-Up of Patients With Thromboangiitis Obliterans Treated With Intravenous Iloprost

et al. 2014

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“…There were 14 early failures and 24 late failures, and the primary, assisted primary, and secondary patency rates at 5 years were 48%, 58%, and 62.5% and at 10 years were 43%, 52.1%, and 56.3%, respectively. Other treatments that have been attempted include bosentan, 84 spinal cord stimulation, 85 and intermittent pneumatic compression. 86 In a pilot study, vascular endothelial growth factor was injected intramuscularly into 7 limbs of patients with critical limb ischemia who also fulfilled the diagnostic criteria for TAO, resulting in ulcer healing in 5 and resolution of rest pain in 2.…”

Section: Weinberg and Jaff Nonatherosclerotic Vascular Disease 219mentioning

confidence: 99%

Nonatherosclerotic Arterial Disorders of the Lower Extremities

Weinberg

Jaff

2012

Circulation

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“…It may be employed in a patient with persistent severe pain and minor ischemic lesions despite abstaining from tobacco. A spinal cord stimulator showed benefit in the treatment of the ischemic extremity lesions of TAO, and this resulted in healing of ulcerations and a good limb survival rate (39,40). However, there is currently no prospective randomized evidence that spinal cord stimulation is effective in healing ischemic lesions.…”

Section: Treatmentmentioning

confidence: 99%

Thromoboagiitis Obliterans (TAO)

Park

Kim

2010

Int J Stem Cells

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Thromboangiitis obliterans (TAO) is nonatherosclerotic inflammatory disease of the peripheral blood vessels, and TAO affects the small and medium sized vessels of the extremities. TAO is mainly seen in young males who smoke, and smoking is strongly associated with the disease course and progression. The diagnosis is made on the basis of the history, the physical examination and the clinical diagnostic criteria. As the bedrock for treating patients with TAO, absolute abstinence from tobacco is most important factor, and patients with TAO are usually managed conservatively. Surgical bypass or endovascular therapy is usually not possible for patients with TAO because of the diffuse segmental involvement and the distal nature of the disease. Therefore, stem cell therapy is considered to be a novel therapeutic modality for treating patients with TAO and who are not eligible for conventional revascularization therapies. In this paper, I have summarized the recent knowledge about TAO and I have reviewed the recent studies that have focused on the treatment of TAO.

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The role of epidural spinal cord stimulation in the treatment of Buerger’s disease

Cited by 69 publications

References 35 publications

Noninvasive Transcutaneous Monitoring in Long-Term Follow-Up of Patients With Thromboangiitis Obliterans Treated With Intravenous Iloprost

Noninvasive Transcutaneous Monitoring in Long-Term Follow-Up of Patients With Thromboangiitis Obliterans Treated With Intravenous Iloprost

Nonatherosclerotic Arterial Disorders of the Lower Extremities

Thromoboagiitis Obliterans (TAO)

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