The Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseases

Zhang, Shuangshuang; Cao, Mengke; Fang, Fang

doi:10.12659/msm.924558

Cited by 28 publications

(21 citation statements)

References 122 publications

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“…However, the outcome of the study and the statistical significance of the obtained results were low, also because of the small number of only eight enrolled patients. With regard to general anticancer activity, epigallocatechin gallate is by far the most investigated of these three compounds and has been attributed both preventive as well as therapeutic potential in the treatment of various types of cancer [ 148 , 149 , 150 , 151 , 152 ].…”

Section: Resultsmentioning

confidence: 99%

Multiple Myeloma Inhibitory Activity of Plant Natural Products

Jöhrer

Ҫiҫek

2021

Cancers

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A literature search on plant natural products with antimyeloma activity until the end of 2020 resulted in 92 compounds with effects on at least one human myeloma cell line. Compounds were divided in different compound classes and both their structure–activity-relationships as well as eventual correlations with the pathways described for Multiple Myeloma were discussed. Each of the major compound classes in this review (alkaloids, phenolics, terpenes) revealed interesting candidates, such as dioncophyllines, a group of naphtylisoquinoline alkaloids, which showed pronounced and selective induction of apoptosis when substituted in position 7 of the isoquinoline moiety. Interestingly, out of the phenolic compound class, two of the most noteworthy constituents belong to the relatively small subclass of xanthones, rendering this group a good starting point for possible further drug development. The class of terpenoids also provides noteworthy constituents, such as the highly oxygenated diterpenoid oridonin, which exhibited antiproliferative effects equal to those of bortezomib on RPMI8226 cells. Moreover, triterpenoids containing a lactone ring and/or quinone-like substructures, e.g., bruceantin, whitaferin A, withanolide F, celastrol, and pristimerin, displayed remarkable activity, with the latter two compounds acting as inhibitors of both NF-κB and proteasome chymotrypsin-like activity.

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Section: Resultsmentioning

confidence: 99%

Multiple Myeloma Inhibitory Activity of Plant Natural Products

Jöhrer

Ҫiҫek

2021

Cancers

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“…Ha et al represented that ROS generation is important in quercetin-meiated apoptotic cell death in Jurkat T cells has been targeted via BCL-XL antiapoptotic action protein (Ha et al, 2019). Epicatechins as shown to modulate autophagy and endoplasmic reticulum (ER) stress-induced apoptostic cell death of human various diseases (Zhang et al, 2020a). Gallic acid, 3,4,5trihydroxy-benzoic acid found in red wine and grapes, acts as an auto-oxidation in addition to produce H 2 O 2 and O 2 − lead to intrinsic mitochondria-mediated apoptosis in prostate cancer cells (Russell Jr et al, 2012).…”

Section: Ros Such As Omentioning

confidence: 99%

Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway

et al. 2021

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Bioactive plant derived compounds are important for a wide range of therapeutic applications, and some display promising anticancer properties. Further evidence suggests that phytochemicals modulate autophagy and apoptosis, the two crucial cellular pathways involved in the underlying pathobiology of cancer development and regulation. Pharmacological targeting of autophagy and apoptosis signaling using phytochemicals therefore offers a promising strategy that is complementary to conventional cancer chemotherapy. In this review, we sought to highlight the molecular basis of the autophagic-apoptotic pathway to understand its implication in the pathobiology of cancer, and explore this fundamental cellular process as a druggable anticancer target. We also aimed to present recent advances and address the limitations faced in the therapeutic development of phytochemical-based anticancer drugs.

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“…Autophagy could protect the host’s overall health, thereby reducing the severity of conditions such as cardiomyopathy, cancer, and neurodegeneration [ 92 , 93 ]. It can play a critical role in the occurrence and development of many human diseases, including cancer, neurological diseases, diabetes, cardiovascular diseases, and injury [ 94 ]. The different beneficial pathways of the host, such as the mitogen-activated protein kinase (MAPK) pathway, inhibition of the mammalian target of rapamycin (mTOR), PI3-kinase-mediated FOXO transcription, Nrf-2 transcription factor, and calorie restriction, can activate autophagy [ 95 , 96 , 97 ].…”

Section: Herbal Teas and Autophagymentioning

confidence: 99%

Role of Herbal Teas in Regulating Cellular Homeostasis and Autophagy and Their Implications in Regulating Overall Health

et al. 2021

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Tea is one of the most popular and widely consumed beverages worldwide, and possesses numerous potential health benefits. Herbal teas are well-known to contain an abundance of polyphenol antioxidants and other ingredients, thereby implicating protection and treatment against various ailments, and maintaining overall health in humans, although their mechanisms of action have not yet been fully identified. Autophagy is a conserved mechanism present in organisms that maintains basal cellular homeostasis and is essential in mediating the pathogenesis of several diseases, including cancer, type II diabetes, obesity, and Alzheimer’s disease. The increasing prevalence of these diseases, which could be attributed to the imbalance in the level of autophagy, presents a considerable challenge in the healthcare industry. Natural medicine stands as an effective, safe, and economical alternative in balancing autophagy and maintaining homeostasis. Tea is a part of the diet for many people, and it could mediate autophagy as well. Here, we aim to provide an updated overview of popular herbal teas’ health-promoting and disease healing properties and in-depth information on their relation to autophagy and its related signaling molecules. The present review sheds more light on the significance of herbal teas in regulating autophagy, thereby improving overall health.

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The Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseases

Cited by 28 publications

References 122 publications

Multiple Myeloma Inhibitory Activity of Plant Natural Products

Multiple Myeloma Inhibitory Activity of Plant Natural Products

Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway

Role of Herbal Teas in Regulating Cellular Homeostasis and Autophagy and Their Implications in Regulating Overall Health

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