The role of epigenetic changes in preeclampsia

Kamrani, Amin; Alipourfard, Iraj; Ahmadi-Khiavi, Homayoon; Yousefi, Mehdi; Rostamzadeh, Davoud; Izadi, Morteza; Ahmadi, Majid

doi:10.1002/biof.1542

Cited by 61 publications

(49 citation statements)

References 133 publications

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“…Posttranslational modification of histones involves covalent modification of specific sites and residues that form specific three-dimensional arrangements of nucleosomes that control the accessibility to transcriptional factors to genes to induce gene expression. Histones are primarily modified at basic lysine and arginine residues, thereby marking active and inactive chromatin states [8]. Important histone modifications include acetylation, methylation, phosphorylation, and ubiquitination.…”

Section: Introductionmentioning

confidence: 99%

The role of cigarette smoke-induced epigenetic alterations in inflammation

Zong

Liu

et al. 2019

Epigenetics & Chromatin

131

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Background: Exposure to cigarette smoke (CS) is a major threat to human health worldwide. It is well established that smoking increases the risk of respiratory diseases, cardiovascular diseases and different forms of cancer, including lung, liver, and colon. CS-triggered inflammation is considered to play a central role in various pathologies by a mechanism that stimulates the release of pro-inflammatory cytokines. During this process, epigenetic alterations are known to play important roles in the specificity and duration of gene transcription. Main text: Epigenetic alterations include three major modifications: DNA modifications via methylation; various posttranslational modifications of histones, namely, methylation, acetylation, phosphorylation, and ubiquitination; and non-coding RNA sequences. These modifications work in concert to regulate gene transcription in a heritable fashion. The enzymes that regulate these epigenetic modifications can be activated by smoking, which further mediates the expression of multiple inflammatory genes. In this review, we summarize the current knowledge on the epigenetic alterations triggered by CS and assess how such alterations may affect smoking-mediated inflammatory responses. Conclusion: The recognition of the molecular mechanisms of the epigenetic changes in abnormal inflammation is expected to contribute to the understanding of the pathophysiology of CS-related diseases such that novel epigenetic therapies may be identified in the near future.

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Section: Introductionmentioning

confidence: 99%

The role of cigarette smoke-induced epigenetic alterations in inflammation

Zong

Liu

et al. 2019

Epigenetics & Chromatin

131

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“…The placenta is the most hypomethylated DNA in human tissue, and DNA methylation increases specifically with gestational age [38], coupled to a high demand for methionine in the third trimester of pregnancy [39]. A striking observation confirms the link between elevated circulating homocysteine, oxidative stress, and methylation [40][41][42]. Homocysteine is both a cause and a consequence of oxidative stress, which can lead to pre-eclampsia [43] A further observation has shown that the oxygen load delivered during parturition in order to stabilize preterm babies affects their methylome.…”

Section: Blastocyst Formation Implantation and Placental Developmentmentioning

confidence: 55%

“…It is not known whether the process is reversible, and the authors [44] suggest that this could affect the response to oxidative stress, DNA repair, and cell progression. Ultimately, placental growth is intricately linked to DNA methylation [40], and correct homeostasis to allow effective methylation avoids adverse pregnancy outcomes such as pre-eclampsia [41][42][43][44][45][46].…”

Section: Blastocyst Formation Implantation and Placental Developmentmentioning

confidence: 99%

Methylation: An Ineluctable Biochemical and Physiological Process Essential to the Transmission of Life

Ménézo¹,

Clément²,

Clément³

et al. 2020

IJMS

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Methylation is a universal biochemical process which covalently adds methyl groups to a variety of molecular targets. It plays a critical role in two major global regulatory mechanisms, epigenetic modifications and imprinting, via methyl tagging on histones and DNA. During reproduction, the two genomes that unite to create a new individual are complementary but not equivalent. Methylation determines the complementary regulatory characteristics of male and female genomes. DNA methylation is executed by methyltransferases that transfer a methyl group from S-adenosylmethionine, the universal methyl donor, to cytosine residues of CG (also designated CpG). Histones are methylated mainly on lysine and arginine residues. The methylation processes regulate the main steps in reproductive physiology: gametogenesis, and early and late embryo development. A focus will be made on the impact of assisted reproductive technology and on the impact of endocrine disruptors (EDCs) via generation of oxidative stress.

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“…9 miRNAs can regulate cell physiological processes, inhibit trophoblast apoptosis, and regulate transcription, translation and signal transduction of placenta-related genes. 10,11 The abnormal expression of miRNAs is closely related to the abnormal placental formation, which greatly increases the risk of the development of PE. 12 It was found that the expression of miR-20a was up-regulated in placenta of PE patients.…”

Section: Introductionmentioning

confidence: 99%

“…MicroRNAs (miRNAs) are a class of small non‐coding RNAs that regulate cell proliferation, differentiation and apoptosis by binding to the 3'‐untranslated region (UTR) of target mRNAs 9 . miRNAs can regulate cell physiological processes, inhibit trophoblast apoptosis, and regulate transcription, translation and signal transduction of placenta‐related genes 10,11 . The abnormal expression of miRNAs is closely related to the abnormal placental formation, which greatly increases the risk of the development of PE 12 .…”

Section: Introductionmentioning

confidence: 99%

Down‐regulated FOXA1 in early‐onset pre‐eclampsia induces apoptosis, and inhibits migration and invasion of trophoblast cells

Zhu

Wei

Wang

et al. 2020

The Journal of Gene Medicine

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Background: Pre-eclampsia (PE) is a major cause of maternal and neonatal mortality and morbidity. Abnormal invasion of trophoblast cells is a major pathogenesis observed in PE. In the present study, we aimed to explore the association between forkhead box A1 (FOXA1) and early-onset pre-eclampsia (EOPE) and to determine the effects of FOXA1 on trophoblast cell apoptosis, migration and invasion. Methods: Clinical data and placentas of patients with EOPE and normal pregnant women were collected in the First Affiliated Hospital of Hainan Medical College. The protein expression levels of FOXA1 in the clinical samples were evaluated by western blotting and immunohistochemistry. The effects of FOXA1 knockdown on HTR-8/SVneo cell apoptosis, migration and invasion were evaluated by flow cytometry, wound healing and transwell invasion assays, respectively. Results: The western blot and immunohistochemical analysis showed that FOXA1 protein expression in placenta of EOPE group was significantly lower than that of normal group. The expression of FOXA1 in the placentas of EOPE and normal pregnant women was negatively correlated with systolic pressure and diastolic pressure. The expression of FOXA1 in EOPE and normal pregnant women was positively correlated with gestation weeks at delivery and neonatal birthweight. In vitro functional studies showed that silencing FOXA1 increased apoptosis, and inhibited the migration and invasion of HTR-8/ SVneo cells. Conclusions: Down-regulation of FOXA1 in the placentas may indicate poor prognosis of EOPE. Silencing of FOXA1 induced apoptosis in trophoblast cells, and impaired the migratory and invasive capacity of trophoblast cells. FOXA1 may represent a potential therapeutic target for EOPE. Juan Zhu and Yunjian Wei equally contributed to this work.

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The role of epigenetic changes in preeclampsia

Cited by 61 publications

References 133 publications

The role of cigarette smoke-induced epigenetic alterations in inflammation

The role of cigarette smoke-induced epigenetic alterations in inflammation

Methylation: An Ineluctable Biochemical and Physiological Process Essential to the Transmission of Life

Down‐regulated FOXA1 in early‐onset pre‐eclampsia induces apoptosis, and inhibits migration and invasion of trophoblast cells

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