2023
DOI: 10.26641/2307-0404.2023.3.288928
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The role of epigenetic modifications in the formation of heterogeneous phenotypes in diabetes mellitus (a literature review)

O.V. Zinych,
A.A. Shuprovych,
O.M. Trofymenko
et al.

Abstract: This review article provides a summary and update on the role of epigenetic mechanisms in predisposition and progression of diabetes, analyzes the data concerning the cause-and-effect relationship between epigenetic changes and the emergence of distinct metabolic phenotypes. Extensive genetic research has enabled the isolation of a group of genes associated with a high risk of developing diabetes. However, numerous data point to the key role of so-called epigenetic modifications in the interaction between gene… Show more

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