The role of Epstein-Barr virus in Hodgkin's disease from different geographical areas.

Weinreb, Miron; Day, Pjr; Niggli, Felix; Powell, Judith E.; Raafat, F.; Hesseling, Peter; Schneider, Johann; Hartley, Patricia; Tzortzatou‐Stathopoulou, Fotini; Khalek, E R A; Mangoud, Amal Mohamed Mahmoud; Elsafy, Usama R.; Madanat, Faris; Sheyyab, M. Al; Mpofu, Christopher; Révész, Tamás; Rafii, R; Tiedemann, Klaus; Waters, Keith; Barrantes, José; Nyongo, Aggrey; Riyat, M S; Mann, J R

doi:10.1136/adc.74.1.27

Cited by 97 publications

(64 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The higher frequency of EBV-positive cases and the Townsend scores among the latter for the mixed cellularity subtypes of HD accords with results from underdeveloped populations in which MC HD has previously been reported to be proportionally more common and is frequently EBV-positive Chang et al, 1993;Leoncini et al, 1996;Weinreb et al, 1996aWeinreb et al, , 1996b. Thus, our results suggest that, within this subtype, socioeconomic factors may be particularly important in determining EBV positivity.…”

Section: Discussionsupporting

confidence: 78%

Effect of material deprivation on Epstein–Barr virus infection in Hodgkin’s disease in the West Midlands

et al. 1999

View full text Add to dashboard Cite

We have used Townsend scores from postcode data to compare levels of material deprivation and Epstein–Barr virus (EBV)-positivity for 223 patients diagnosed with Hodgkin's disease (HD) in the period 1981–1997. The presence of EBV in HD tumours was determined using in situ hybridization to target the abundantly expressed EBV early RNAs. EBV was detected in the malignant Hodgkin and Reed–Sternberg cells in 47/223 HD cases (21%). There was found to be a tendency for higher Townsend scores (indicative of higher levels of material deprivation) in EBV-positive HD patients, but this association was not statistically significant. When various subgroups of patients from the study were examined separately the indication of higher Townsend scores in EBV-positive patients was found to be more marked for patients with mixed cellularity disease ( P = 0.09) and for females ( P = 0.03). The results of this study suggest that differences in the level of material deprivation are important in determining the likelihood of EBV-positive HD in the UK, particularly for certain subgroups of patients. It is not known what specific socioeconomic factors are responsible for these differences, although alterations in the timing or rate of primary EBV infection, or decline in the level of EBV-specific immunity, may be important. © 1999 Cancer Research Campaign

show abstract

Section: Discussionsupporting

confidence: 78%

Effect of material deprivation on Epstein–Barr virus infection in Hodgkin’s disease in the West Midlands

et al. 1999

View full text Add to dashboard Cite

show abstract

“…Quintanilla-Martinez et al (1996) reported that the percentage of 50 adult Mexicans with EBV-positive tumors was high (70%) and did not vary significantly by age, sex or histologic subtype; these findings may largely reflect the higher risk of EBV-associated HD in Hispanics, given the absence of an independent risk of EBVpositive HD with regional economic development in adults in our case series. An international study of 277 pediatric HD patients described a protective effect of increasing age in childhood on risk of EBV-positive disease, consistent with the pattern in Figure 2, and significant inter-country differences in risk (Weinreb et al, 1996). However, this analysis was not controlled for ethnicity or regional economic status, which may partly explain the association of EBV positivity with nationality.…”

Section: Discussionsupporting

confidence: 53%

“…However, detailed epidemiologic characterization of EBV-classified HD has been limited. Some studies have reported EBV-positive HD to be more common in males, in 1 of the 4 histologic subtypes, in children and older adults, in Hispanic populations, and in economically lessdeveloped countries (Pallesen et al, 1991a;Gulley et al, 1994;Chang et al, 1993;Ambinder et al, 1993;Khan et al, 1993;Zarate-Osorno et al, 1995;Quintanilla-Martinez et al, 1996;Armstrong et al, 1993;Jarrett et al, 1991;Weinreb et al, 1996). However, these findings, frequently based on small case series from populations with differing HD risks, vary widely and often conflict.…”

mentioning

confidence: 99%

Epstein‐Barr virus‐associated Hodgkin's disease: Epidemiologic characteristics in international data

et al. 1997

View full text Add to dashboard Cite

Hodgkin's disease (HD) has long been suspected to have an infectious precursor, and indirect evidence has implicated Epstein-Barr virus (EBV), a ubiquitous herpesvirus, as a causal agent. Recent molecular studies using EBER in situ hybridization or latency membrane protein-1 (LMP-1) immunohistochemistry have identified EBV latent infection in up to 50% of HD tumors. However, the epidemiologic features of these cases have not been examined in detail. To explore the epidemiology of EBV-positive HD so as to understand the role of EBV in HD etiology more clearly, this project accumulated patient data from 14 studies that had applied these EBV assays to HD tumors. With information on age at diagnosis, sex, ethnicity, histologic subtype, country of residence, clinical stage and EBV tumor status from 1,546 HD patients, we examined risk for EBV-positive disease using logistic regression. Forty percent of subjects had EBV-positive tumors, and EBV prevalence varied significantly across groups defined by the study variables. Odds ratios (OR) for EBV-associated HD were significantly elevated for Hispanics vs. whites (OR 5 4.1), mixed cellularity vs. nodular sclerosis histologic subtypes (OR 5 7.3, 13.4, 4.9 for ages 0-14, 15-49, 501 years), children from economically less-developed vs. more-developed regions and young adult males vs. females (OR 5 2.5). These findings suggest that age, sex, ethnicity and the physiologic effects of poverty may represent biologic modifiers of the EBV association and confirm that this association is strongly but variably linked to histologic subtype. The data augment biologic evidence that EBV is actively involved in HD pathogenesis in some cases but describe epidemiologic complexity in this process. Int.

show abstract

“…-Europe [8,13,[31][32][33][34][35][36][37][38][39][40][41]; between 27% of cases in Sweden [41] and 56% of cases in Italy [13] were positive, with a higher rate in two reports: 79% in Switzerland [31] and 91% in Greece [8] -USA [12,[42][43][44]: between 25% and 65% of cases were positive -Australia [8]: a high frequency of positive cases (69%).…”

Section: Discussionmentioning

confidence: 99%

“…-Middle East (including Tunisia) [4][5][6][7][8][9][10][11][12]: between 28% of cases in a series from Jordan [12] and 70% of cases from Tunisia [4] were EBV-positive with HL; for Egypt [8], 50% were positive and 67% were of the NS type, which is similar to our findings -East Africa [13][14][15][16]: between 44% and 92% of cases were positive in Kenya -Central and South America [17][18][19][20][21][22][23]: between 31% of cases in Argentina [23] and 84% of cases in Peru [17] were positive -Asia [14,[24][25][26][27][28][29][30]: between 39% of cases in China [30] and 82% of cases in India [24] were positive, and the percentage of positive cases in most other countries was high (50% to 69%). For each country, the first column shows the number (n°) of cases studied whereas the other columns show the percentages of positive cases.…”

Section: Discussionmentioning

confidence: 99%

Epstein–Barr virus and Hodgkin’s lymphoma in Cairo, Egypt

et al. 2010

View full text Add to dashboard Cite

Fifty-five consecutive cases of Hodgkin's lymphoma (HL), collected between 1996 and 1998 from Cairo, Egypt, were histologically subtyped, phenotyped, and then studied for the presence of Epstein-Barr virus (EBV). We used immunohistochemical stains for EBV latent membrane protein 1 (LMP-1) and in situ hybridization stains for EBV-encoded small RNA (EBER-1) transcripts. Forty-five cases (82%) had classic HL (cHL), and ten cases (18%) had nodular lymphocyte predominant HL (NLPHL), with each group expressing its typical phenotype. LMP-1 stains were positive in 63% and 0% of cHL and NLPHL cases, respectively. EBER-positive Reed-Sternberg cells and variants were also present in 62% and 0% of each group, respectively. The cHL cases showed variable EBER positivity: nodular sclerosis, 58%; mixed cellularity, 100%; lymphocyte depletion, 100%; and unclassifiable, 67%. Our findings are similar to those from other developing countries and point towards a pathogenic role of EBV in cHL.

show abstract

The role of Epstein-Barr virus in Hodgkin's disease from different geographical areas.

Cited by 97 publications

References 25 publications

Effect of material deprivation on Epstein–Barr virus infection in Hodgkin’s disease in the West Midlands

Effect of material deprivation on Epstein–Barr virus infection in Hodgkin’s disease in the West Midlands

Epstein‐Barr virus‐associated Hodgkin's disease: Epidemiologic characteristics in international data

Epstein–Barr virus and Hodgkin’s lymphoma in Cairo, Egypt

Contact Info

Product

Resources

About