The role of ER stress and ATP/AMPK in oxidative stress meditated hepatotoxicity induced by citrinin

Wu, Jing; Yang, Chenglin; Yang, Mengran; Liang, Zengenni; Wu, You; Kong, Xiangyi; Fan, Hui; Wang, Siqi; Ning, Can; Xiao, Wenguang; Ye, Jin; Yi, Jine; Yuan, Zhihang

doi:10.1016/j.ecoenv.2022.113531

Cited by 24 publications

(11 citation statements)

References 35 publications

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“…It has been demonstrated that ERS, oxidative stress, and apoptosis are interrelated. Our previous studies confirmed that inhibition of ERS reduced the hepatotoxicity of CTN in vivo and in vitro, which was related to inhibition of oxidative stress and apoptosis [ 6 , 13 ]. Therefore, CTN-induced testicular injury and spermatogenesis impairment may be attributed to ERS.…”

Section: Discussionsupporting

confidence: 82%

“…Previous studies have reported that CTN toxicity is primarily mediated via oxidative stress and apoptosis [ 4 ]. Similarly, our previous study confirmed that CTN triggers oxidative stress and apoptosis in hepatocytes in vivo and in vitro, and this is regulated by endoplasmic reticulum stress (ERS) [ 6 , 13 ]. In the context of enterotoxicity, it has also been reported that CTN causes ERS-induced apoptosis in intestinal cells [ 14 ].…”

Section: Introductionsupporting

confidence: 59%

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Citrinin Exposure Induced Testicular Damage and Spermatogenesis Disorder by Triggering Endoplasmic Reticulum Stress

Fan

et al. 2023

Foods

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Damage to the reproductive system is the key factor leading to male infertility. Citrinin (CTN) is produced by Penicillium and Aspergillus in nature, and is definitely found in food and animal feed. Studies have revealed that CTN can cause damage to male reproductive organs and reduce fertility, but the mechanism of toxicity has not been revealed. In the present study, male Kunming mice were given different doses of CTN (0, 1.25, 5 or 20 mg/kg BW) by intragastric administration. The results demonstrated that CTN exposure caused disorder of androgen, a decline in sperm quality, and histopathological damage of testis. The inhibition of the expression of ZO-1, claudin-1 and occludin suggests that the blood-testis barrier (BTB) was damaged. Simultaneously, CTN inhibited the activity of antioxidant enzymes such as CAT and SOD, and promoted the production of MDA and ROS, resulting in oxidative damage of testis. Additionally, apoptotic cells were detected and the ratio of Bax/Bcl-2 was increased. Not only that, CTN activated the expression of endoplasmic reticulum stress (ERS)-related proteins IRE1, ATF6, CHOP, and GRP78. Interestingly, 4-Phenylbutyric Acid (4-PBA, an ERS inhibitor) treatment blocked the adverse effects of CTN exposure on male reproduction. In short, the findings suggested that CTN exposure can cause damage to mouse testis tissue, in which ERS exhibited an important regulatory role.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionsupporting

confidence: 59%

Citrinin Exposure Induced Testicular Damage and Spermatogenesis Disorder by Triggering Endoplasmic Reticulum Stress

Fan

et al. 2023

Foods

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“…Furthermore, compound 7 has also been reported that it presented strong antibacterial activity against methicillin-resistant S. aureus and rifampicin-resistant S. aureus with the MIC values of 3.90 and 0.97 μg/mL, respectively [ 41 ]. However, there was evidence that compound 7 showed nephrotoxic, hepatotoxic, and carcinogenic activity [ 42 , 43 ]. Therefore, it might not be suitable for developing antibiotic.…”

Section: Discussionmentioning

confidence: 99%

Diversity, antibacterial and phytotoxic activities of culturable endophytic fungi from Pinellia pedatisecta and Pinellia ternata

et al. 2023

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Background Endophytic fungi of medicinal plants, as special microorganisms, are important sources of antibacterial compounds. However, the diversity and antibacterial activity of endophytic fungi from Pinellia Tenore have not been systematically studied. Results A total of 77 fungi were isolated from roots, stems, leaves, and tubers of Pinellia ternata and P. pedatisecta. All fungi were belonged to five classes and twenty-five different genera. Biological activities tests indicated that 21 extracts of endophytic fungi exhibited antibacterial activities against at least one of the tested bacteria, and 22 fermentation broth of endophytic fungi showed strong phytotoxic activity against Echinochloa crusgalli with the inhibition rate of 100%. Furthermore, four compounds, including alternariol monomethyl ether (1), alternariol (2), dehydroaltenusin (3) and altertoxin II (4), and three compounds, including terreic acid (5), terremutin (6), citrinin (7), were isolated from Alternaria angustiovoidea PT09 of P. ternata and Aspergillus floccosus PP39 of P. pedatisecta, respectively. Compound 5 exhibited strong antibacterial activities against Escherichia coli, Micrococcus tetragenus, Staphylococcus aureus, and Pseudomonas syringae pv. actinidiae with the inhibition zone diameter (IZD) of 36.0, 31.0, 33.7, 40.2 mm and minimum inhibitory concentration (MIC) values of 1.56, 3.13, 1.56, 1.56 μg/mL respectively, which were better than or equal to those of positive gentamicin sulfate. The metabolite 7 also exhibited strong antibacterial activity against P. syringae pv. actinidiae with the IZD of 26.0 mm and MIC value of 6.25 μg/mL. In addition, the compound 7 had potent phytotoxic activity against E. crusgalli with the inhibition rate of 73.4% at the concentration of 100 μg/mL. Conclusions Hence, this study showed that endophytic fungi of P. ternata and P. pedatisecta held promise for the development of new antibiotic and herbicide resources.

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“…Postmortem environmental changes result in excessive production of ROS in myocytes, such that the antioxidant defense system becomes insufficient to combat ROS, resulting in an imbalance between the oxidative and antioxidant systems and causing oxidative stress in the myocytes ( 74 ). Oxidative stress mediates protein oxidation, weakens the activity of proteolytic enzymes, and causes cross-linking and polymerization between protein molecules, thereby affecting the degradation of skeletal proteins, which is detrimental to the tenderization of muscles ( 75 ).…”

Section: Parp1 Regulates the Tenderization Mechanism Of Postmortem Mu...mentioning

confidence: 99%

Biological function, mediate cell death pathway and their potential regulated mechanisms for post-mortem muscle tenderization of PARP1: A review

Luo

et al. 2022

Front. Nutr.

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Tenderness is a key attribute of meat quality that affects consumers’ willingness to purchase meat. Changes in the physiological environment of skeletal muscles following slaughter can disrupt the balance of redox homeostasis and may lead to cell death. Excessive accumulation of reactive oxygen species (ROS) in the myocytes causes DNA damage and activates poly ADP-ribose polymerase 1 (PARP1), which is involved in different intracellular metabolic pathways and is known to affect muscle tenderness during post-slaughter maturation. There is an urgent requirement to summarize the related research findings. Thus, this paper reviews the current research on the protein structure of PARP1 and its metabolism and activation, outlines the mechanisms underlying the function of PARP1 in regulating muscle tenderness through cysteine protease 3 (Caspase-3), oxidative stress, heat shock proteins (HSPs), and energy metabolism. In addition, we describe the mechanisms of PARP1 in apoptosis and necrosis pathways to provide a theoretical reference for enhancing the mature technology of post-mortem muscle tenderization.

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The role of ER stress and ATP/AMPK in oxidative stress meditated hepatotoxicity induced by citrinin

Cited by 24 publications

References 35 publications

Citrinin Exposure Induced Testicular Damage and Spermatogenesis Disorder by Triggering Endoplasmic Reticulum Stress

Citrinin Exposure Induced Testicular Damage and Spermatogenesis Disorder by Triggering Endoplasmic Reticulum Stress

Diversity, antibacterial and phytotoxic activities of culturable endophytic fungi from Pinellia pedatisecta and Pinellia ternata

Biological function, mediate cell death pathway and their potential regulated mechanisms for post-mortem muscle tenderization of PARP1: A review

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