The Role of ErbB Receptors in Endometrial Cancer

Georgios, Adonakis; Georgios, Androutsopoulos

doi:10.5772/26858

Cited by 6 publications

(9 citation statements)

References 109 publications

(181 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overall, EGFR overexpression is reported in 43–67% of unselected EC cases [ 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 ]. EGFR overexpression is present in approximately 46% of type I EC (endometrioid) cases [ 149 , 151 , 156 ]. EGFR overexpression is observed in 34–50% of type II EC (papillary serous, clear cell, undifferentiated) cases [ 149 , 151 , 156 , 157 , 158 , 159 ].…”

Section: Erbb Receptors In Endometrial Cancermentioning

confidence: 99%

“…EGFR overexpression is present in approximately 46% of type I EC (endometrioid) cases [ 149 , 151 , 156 ]. EGFR overexpression is observed in 34–50% of type II EC (papillary serous, clear cell, undifferentiated) cases [ 149 , 151 , 156 , 157 , 158 , 159 ].…”

Section: Erbb Receptors In Endometrial Cancermentioning

confidence: 99%

“…However, ΕrbB-2 overexpression and ΕrbB-2 gene amplification are present in only 8–15% and 3% of type I EC cases, respectively [ 144 , 149 , 156 , 160 , 161 , 162 , 163 ]. In contrast, ΕrbB-2 overexpression and ErbB-2 gene amplification are more common in type II EC cases [ 149 , 151 , 156 , 157 , 158 , 159 ].…”

Section: Erbb Receptors In Endometrial Cancermentioning

confidence: 99%

“…Moreover, the exact frequency of ErbB-2 overexpression and ΕrbB-2 gene amplification in type II EC remains controversial, as there are many racial differences [ 149 , 151 , 157 , 164 , 165 ]. More specifically, ErbB-2 overexpression and ΕrbB-2 gene amplification are more common in African—American patients with type II EC, when compared with Caucasian individuals [ 164 , 165 ].…”

Section: Erbb Receptors In Endometrial Cancermentioning

confidence: 99%

“…Likewise, ErbB-2 overexpression and ΕrbB-2 gene amplification have significant variations among different histologic subtypes of type II EC [ 149 , 151 , 157 , 160 , 165 , 166 , 167 ]. ErbB-2 overexpression and ΕrbB-2 gene amplification are reported in 18–80% and 17–47% of papillary serous EC cases, respectively [ 149 , 151 , 160 , 163 , 165 , 166 , 167 ], and 33% and 16–50% of clear cell EC cases, respectively [ 149 , 151 , 160 , 167 ].…”

Section: Erbb Receptors In Endometrial Cancermentioning

confidence: 99%

See 4 more Smart Citations

The ErbB Signaling Network and Its Potential Role in Endometrial Cancer

Androutsopoulos,

Styliara,

Zarogianni

et al. 2023

Epigenomes

View full text Add to dashboard Cite

Endometrial cancer (EC) is the second most common malignancy of the female reproductive system worldwide. The updated EC classification emphasizes the significant role of various signaling pathways such as PIK3CA-PIK3R1-PTEN and RTK/RAS/β-catenin in EC pathogenesis. Some of these pathways are part of the EGF system signaling network, which becomes hyperactivated by various mechanisms and participates in cancer pathogenesis. In EC, the expression of ErbB receptors is significantly different, compared with the premenopausal and postmenopausal endometrium, mainly because of the increased transcriptional activity of ErbB encoding genes in EC cells. Moreover, there are some differences in ErbB-2 receptor profile among EC subgroups that could be explained by the alterations in pathophysiology and clinical behavior of various EC histologic subtypes. The fact that ErbB-2 receptor expression is more common in aggressive EC histologic subtypes (papillary serous and clear cell) could indicate a future role of ErbB-targeted therapies in well-defined EC subgroups with overexpression of ErbB receptors.

show abstract

Section: Erbb Receptors In Endometrial Cancermentioning

confidence: 99%

Section: Erbb Receptors In Endometrial Cancermentioning

confidence: 99%

Section: Erbb Receptors In Endometrial Cancermentioning

confidence: 99%

Section: Erbb Receptors In Endometrial Cancermentioning

confidence: 99%

Section: Erbb Receptors In Endometrial Cancermentioning

confidence: 99%

See 3 more Smart Citations

The ErbB Signaling Network and Its Potential Role in Endometrial Cancer

Androutsopoulos,

Styliara,

Zarogianni

et al. 2023

Epigenomes

View full text Add to dashboard Cite

show abstract

Expression and potential role of ErbB receptors in type II endometrial cancer

Georgios

Adonakis

Liava

et al. 2013

European Journal of Obstetrics & Gynecology and Reproductiv

View full text Add to dashboard Cite

Present and Future in Endometrial Cancer Treatment

Georgios¹

2015

OGIJ

View full text Add to dashboard Cite

additional omentectomy, appendectomy and biopsy of any suspected lesion. [3][4][5]10,11,14 Positive pelvic washings should be reported separately, although they do not affect FIGO staging for EC. 9Laparotomy is the preferable surgical technique for systematic surgical staging in most EC patients. [3][4][5]10,11,15,16 However in EC patients with early stage disease, we can also use minimally invasive techniques (laparoscopy, robotic-assisted surgery) for the same purpose. [2][3][4][5]8,[10][11][12][15][16][17][18] It is widely accepted that minimally invasive techniques have many significant advantages (smaller incisions, improved visualization, shorter hospital stay, less need for analgesics, quicker recovery and lower risk of postoperative complications). [3][4][5]8,[10][11][12][15][16][17][18][19] Those advantages are very important, especially in overweight and elderly patients. [3][4][5]8,[10][11][12][15][16][17][18][19] The various surgical techniques (laparotomy, minimally invasive techniques) that applied in EC patients, have relatively small differences in recurrence rates. 15,16 Moreover, those surgical techniques (laparotomy, minimally invasive techniques) associated with similar overall and disease-free survival rates. 10,12,15,16

show abstract

The Role of ErbB Receptors in Endometrial Cancer

Cited by 6 publications

References 109 publications

The ErbB Signaling Network and Its Potential Role in Endometrial Cancer

The ErbB Signaling Network and Its Potential Role in Endometrial Cancer

Expression and potential role of ErbB receptors in type II endometrial cancer

Present and Future in Endometrial Cancer Treatment

Contact Info

Product

Resources

About