The role of estrogen and Cu, Zn-SOD on histological changes after menopause in female rat parotid

Oestrogen receptor β expression in pleomorphic adenomas of the parotid gland

“…However levels of receptor ERα in normal and tumour tissues have been low or undetectable and the underlying mechanisms undefined 24 25 26 27 28. This study has provided strong evidence in support of an earlier small study suggesting that oestrogen activity in salivary gland tissues is largely mediated by ERβ 28.…”

“…ERβ is now known to exist as several isoforms 23. ERα expression has been demonstrated in the oral mucosa, but levels in normal salivary gland tissues and tumours of the salivary gland have generally been low and data are conflicting 24 25 26 27 28. These inconsistencies have been attributed to differences in the sensitivities and specificities of the assays.…”

Relationship of lumbar spine bone mineral density and oral dryness feeling in menopause

“…8,16,17 Today, the administration of estrogen to postmenopausal women was reported to be useful for preventing senile disturbances, specially osteoporosis. 7,18 Taking into consideration the results of previous studies that had shown lower salivary estrogen 10 and higher cortisol 12 and PTH 11 in saliva and serum in postmenopausal women with OD feeling, and because of the effects of estrogen, PTH, and cortisol in bone turnover, lower BMD in the case group was expected.…”

An experimental study of menopause induced by bilateral ovariectomy and mechanistic effects of mesenchymal stromal cell therapy on the parotid gland of a rat model

“…Additionally, Gejima et al (2007) detected ER-α in the parotid gland of adult female rats. The severe affection of the parotid gland in menopausal animal models has also been documented (Kusunoki et al, 2006;Mohamed et al, 2015).…”

“…Recently, association between E2 deficiency and histological alterations induced by apoptosis in the rat ' s parotid gland has been noticed (Kusunoki et al,2004). This apoptotic induction is caused mainly by free radicals (Kusunoki et al, 2006).…”