2015
DOI: 10.1007/s12018-015-9188-7
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The Role of Estrogen Receptor in Bone Cells

Abstract: Estrogen is an essential regulator of the skeleton homeostasis during both childhood and adulthood. As a matter of fact, estrogens and selective estrogen receptor modulators are considered essential treatment tools by clinicians to prevent bone fractures in postmenopausal women. All these observations promote a great interest in discovering the mechanisms by which estrogens protect bone. Over the past years, research performed from several groups has established that the osteoprotective effects of estrogens ar… Show more

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Cited by 6 publications
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“…The dimerization of OPG increases the affinity of OPG to RANKL dramatically [20]. OPG expression can be upregulated by several factors such as TRAIL, Wnt/β catenin signaling, IL-1β, TNFα, and estrogen, and down regulated by TGF-β and parathyroid hormone (PTH) [17,21]. The final inhibitory effect of OPG on RANKL is dependent on its binding to these ligands [22,23].…”
Section: The Rank/rankl Signaling Networkmentioning
confidence: 99%
“…The dimerization of OPG increases the affinity of OPG to RANKL dramatically [20]. OPG expression can be upregulated by several factors such as TRAIL, Wnt/β catenin signaling, IL-1β, TNFα, and estrogen, and down regulated by TGF-β and parathyroid hormone (PTH) [17,21]. The final inhibitory effect of OPG on RANKL is dependent on its binding to these ligands [22,23].…”
Section: The Rank/rankl Signaling Networkmentioning
confidence: 99%