2009
DOI: 10.1007/s12325-009-0026-5
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The role of eszopiclone in the treatment of insomnia

Abstract: Eszopiclone has been shown to be an efficacious and cost-effective option for the treatment of transient and chronic insomnia in adults.

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Cited by 18 publications
(14 citation statements)
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“…Eszopiclone (Box 1), the S-enantiomer of racemic zopiclone, became available as a prescription hypnotic drug in the United States in December 2004 [1][2][3][4][5][6]. The extent of use has been relatively constant over the last 5 years, with retail prescriptions in the range of 5 to 6 million per year, and total retail costs reaching nearly US$1 billion ( Figure 1) [7,8].…”
Section: Introductionmentioning
confidence: 99%
“…Eszopiclone (Box 1), the S-enantiomer of racemic zopiclone, became available as a prescription hypnotic drug in the United States in December 2004 [1][2][3][4][5][6]. The extent of use has been relatively constant over the last 5 years, with retail prescriptions in the range of 5 to 6 million per year, and total retail costs reaching nearly US$1 billion ( Figure 1) [7,8].…”
Section: Introductionmentioning
confidence: 99%
“…2,12 Nonbenzodiazepine drugs like zolpidem, zaleplon, and zopiclone all have high affinity and selectivity for the α 1 -subunit of the GABA A receptor complex. 24 Zolpidem improves sleep maintenance shortly after administration, but the effect disappears at a later stage. 1,25,26 It may cause adverse effects like daytime drowsiness, dizziness, headache, and nausea.…”
Section: Benzodiazepines and Related Drugs In Insomniamentioning
confidence: 99%
“…28 Zopiclone and its active stereoisomer, eszopiclone, have both been shown to be effective and safe in patients with primary insomnia. 24,29 In general, nonbenzodiazepine sedative hypnotics, although effective in submit your manuscript | www.dovepress.com Dovepress Dovepress reducing sleep onset latency, are only moderately effective in increasing sleep efficiency and total sleep time. 30 Indeed, an ideal hypnotic drug should not only decrease sleep onset latency but should also increase total sleep time and sleep efficiency.…”
Section: Benzodiazepines and Related Drugs In Insomniamentioning
confidence: 99%
“…Zolpidem, zopiclone and zaleplon all having high affinity and selectivity for the α 1 -subunit of the GABA A receptor complex are included in this group [30]. Generally Z drug hypnotics, although effective in reducing sleep latency, are only moderately effective in increasing sleep efficiency [31].…”
Section: Bzd and Related Drugs In Insomniamentioning
confidence: 99%
“…In addition, zolpidem may induce adverse effects like headache, nausea and daytime drowsiness. Zaleplon is effective to decrease sleep latency [33] and together with zopiclone and its active stereoisomer eszopiclone have been shown effective and safe in patients with primary insomnia [30,34]. It must be noted that the use of all these agents are problematic in individuals prone to drug abuse.…”
Section: Bzd and Related Drugs In Insomniamentioning
confidence: 99%