2022
DOI: 10.3389/fddev.2022.1049848
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The role of excipients in promoting topical and transdermal delivery: Current limitations and future perspectives

Abstract: Topical and transdermal delivery has historically offered an attractive and non-invasive route for administration of medicines. However, human skin is known to be a remarkably good barrier to the permeation of substances. The majority of dermatological drug products have been reported to only deliver a portion of the total dose applied, often resulting in low drug bio-availability at the site of action inside the skin. This insufficient formulation performance, coupled with the fact that percutaneous delivery … Show more

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Cited by 7 publications
(4 citation statements)
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“…The active ingredient components of the avocado oil nanoemulsion can be absorbed by using IPM in conjunction with surfactants and cosurfactants, such as tween 80 and PEG 400, because the nanoemulsion's smaller droplet size can improve the active ingredient's ability to permeate the membrane (Iliopoulos et al, 2022;Pakki et al, 2019). Tween and PEG 400 play an important role in the ability of nanoemulsions to release active ingredients by influencing the surface layer of the nanoemulsion (Akhtar et al, 2011;Nastiti et al, 2017).…”
Section: The Results Of the Effectiveness Of Avocado Oil Nanoemulsion...mentioning
confidence: 99%
“…The active ingredient components of the avocado oil nanoemulsion can be absorbed by using IPM in conjunction with surfactants and cosurfactants, such as tween 80 and PEG 400, because the nanoemulsion's smaller droplet size can improve the active ingredient's ability to permeate the membrane (Iliopoulos et al, 2022;Pakki et al, 2019). Tween and PEG 400 play an important role in the ability of nanoemulsions to release active ingredients by influencing the surface layer of the nanoemulsion (Akhtar et al, 2011;Nastiti et al, 2017).…”
Section: The Results Of the Effectiveness Of Avocado Oil Nanoemulsion...mentioning
confidence: 99%
“…A nuanced understanding and deliberate adjustment of composition facilitate the design of formulations poised to enhance skin penetration, presenting promising avenues for advancements in dermatological and transdermal therapeutic applications. [29] Numerous active pharmaceutical ingredients (APIs) exhibit limited aqueous solubility, resulting in suboptimal bioavailability following both oral and topical administration. Nanocrystals, a widely accepted and versatile formulation strategy, have proven efficacious in mitigating poor solubility.…”
Section: Composition Of Nanocrystalmentioning
confidence: 99%
“…A nuanced understanding and deliberate adjustment of composition facilitate the design of formulations poised to enhance skin penetration, presenting promising avenues for advancements in dermatological and transdermal therapeutic applications. [ 29 ]…”
Section: Evolution and Challenges Associated With Current Drug Delive...mentioning
confidence: 99%
“…Cutaneous topical administration of drugs and cosmetic actives presents numerous advantages for the treatment of dermatological diseases or conditions, such as fewer adverse effects related to systemic drug exposure, avoidance of the first-pass metabolism that impacts bioavailability and dose reduction, and targeted drug delivery [ 1 , 2 ]. However, topical therapies are always limited by the skin barrier function, mainly provided by the stratum corneum—the most superficial epidermal layer [ 3 , 4 ].…”
Section: Introductionmentioning
confidence: 99%