We report organic solar cells fabricated with small-molecule organic semiconductor tetracene/ C 60 heterojunction as the photoactive layer. The external power conversion efficiency of the devices under AM 1.5 solar illumination at 100 mW/ cm 2 ͑1 sun͒ is 2.3± 0.5% with relatively high open-circuit voltage ͑Voc= 0.58± 0.06 V͒ compared to most of the other small-molecular donor-acceptor ͑D-A͒ heterojunction solar cells reported so far. Using atomic force microscopy and x-ray diffraction we found that tetracene thin films consist of submicron-sized grains with rough surface and well defined molecular order. Therefore, using high mobility polycrystalline tetracene thin films for D-A heterojunction devices dramatically increases area of tetracene and C 60 interface for exciton diffusion to reduce the recombination.