The role of exercise training on cardiovascular peptides in patients with heart failure: A systematic review and meta-analysis

Malandish, Abbas; Ghadamyari, Niloufar; Karimi, Asma; Naderi, Mahdi

doi:10.1016/j.crphys.2022.06.004

Cited by 6 publications

(15 citation statements)

References 59 publications

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“…According to the findings, ET, particularly aerobic exercise, can increase natriuretic peptide levels, which may indicate that the body has adapted positively to aerobic exercise. 34) …”

Section: Exercisementioning

confidence: 99%

Lifestyle Modification in Heart Failure Management: Are We Using Evidence-Based Recommendations in Real World Practice?

2023

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The heart failure (HF) guideline’s purpose is to assist medical professionals while treating patients with HF in accordance with the best current research. Many cases of HF are both, avoidable and treatable thanks to scientific trials. Management is, therefore, based on lifestyle changes, also called non-pharmacological treatment. These, based on lifestyle changes, should be recommended in every patient at risk for HF or with diagnosed of HF, but evidence in itself is scarce. DASH Diet could be clearly beneficial while Mediterranean diet doesn't have enough evidence at the present moment. Smoking should be stopped, and excessive amounts of alcohol drinking avoided, but there is no clinical trial nor registry performed on these aspects. A moderate salt restriction is better than a strict reduction. Exercise and cardiac rehabilitation are beneficial but there are no clear recommendations about type, duration, etc. Most of the evidence that we have in HF patients with obesity is contradictory. Finally, due to the high number of aged frail patients in HF lifestyle changes should be individualized, but again available data is scant. Therefore, due to the lack of current evidence, these gaps need to be considered and need new efforts on investigation in the next future.

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“…According to the findings, ET, particularly aerobic exercise, can increase natriuretic peptide levels, which may indicate that the body has adapted positively to aerobic exercise. 34) …”

Section: Exercisementioning

confidence: 99%

Lifestyle Modification in Heart Failure Management: Are We Using Evidence-Based Recommendations in Real World Practice?

2023

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“…A meta-analysis study shows that exercise, especially aerobic exercise, significantly decreases the N-terminal-pro hormone B-type natriuretic peptide (BNP) in patients with heart failure, regardless of obesity status [ 89 ]. A 12 week exercise program combining aerobic and resistance training on obese β-amyloid-treated rats significantly alleviated the side effects of β-amyloid plaque on brain function, and improved cardiopulmonary function, muscular endurance, and short-term memory ability [ 90 ].…”

Section: Clinical Management Of Obesitymentioning

confidence: 99%

The Related Metabolic Diseases and Treatments of Obesity

2022

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Obesity is a chronic disease characterized by the abnormal or excessive accumulation of body fat, affecting more than 1 billion people worldwide. Obesity is commonly associated with other metabolic disorders, such as type 2 diabetes, non-alcoholic fatty liver disease, cardiovascular diseases, chronic kidney disease, and cancers. Factors such as a sedentary lifestyle, overnutrition, socioeconomic status, and other environmental and genetic conditions can cause obesity. Many molecules and signaling pathways are involved in the pathogenesis of obesity, such as nuclear factor (NF)-κB, Toll-like receptors (TLRs), adhesion molecules, G protein-coupled receptors (GPCRs), programmed cell death 1 (PD-1)/programmed death-ligand 1 (PD-L1), and sirtuin 1 (SIRT1). Commonly used strategies of obesity management and treatment include exercise and dietary change or restriction for the early stage of obesity, bariatric surgery for server obesity, and Food and Drug Administration (FDA)-approved medicines such as semaglutide and liraglutide that can be used as monotherapy or as a synergistic treatment. In addition, psychological management, especially for patients with obesity and distress, is a good option. Gut microbiota plays an important role in obesity and its comorbidities, and gut microbial reprogramming by fecal microbiota transplantation (FMT), probiotics, prebiotics, or synbiotics shows promising potential in obesity and metabolic syndrome. Many clinical trials are ongoing to evaluate the therapeutic effects of different treatments. Currently, prevention and early treatment of obesity are the best options to prevent its progression to many comorbidities.

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“…Inflammaging and obesity are chronic low-grad inflammation statuses during aging [1] , [2] as well as risk factors for cardiovascular diseases (CVDs), especially heart failure (HF) [2] . HF is a heterogeneous pathophysiological syndrome of ventricular dysfunction [3] , [4] , which is associated with high circulating chronic inflammatory cytokines, low-grad inflammation, systemic inflammation, and obesity [3] , [4] , [5] , [6] . Chronic inflammatory cytokines (tumor-necrosis-factor-alpha [TNF-α], interleukin-6 [IL-6], IL-1-beta, IL-8) and low-grad inflammation (high sensitivity C-reactive protein [hs-CRP]) during aging are inflammaging biomarkers that can be translated to metabolic disorders such as clinical HF [1] , [2] .…”

Section: Introductionmentioning

confidence: 99%

“…To date, the role of the inflammaging process in clinical HF remains unknown. The American Heart Association (AHA) endorses the use of exercise-based cardiac rehabilitation as a class-1 recommendation for clinical HF [4] , [7] . Numerous studies demonstrated that regular exercise training reduces chronic inflammatory cytokines, systemic inflammation and cardiovascular peptides [4] , and improves restore endothelial function [8] , cardiorespiratory fitness (CRF) [9] , cardiac function, and clinical progression and survival in patients with HF [4] , [8] , [9] .…”

Section: Introductionmentioning

confidence: 99%

“…The American Heart Association (AHA) endorses the use of exercise-based cardiac rehabilitation as a class-1 recommendation for clinical HF [4] , [7] . Numerous studies demonstrated that regular exercise training reduces chronic inflammatory cytokines, systemic inflammation and cardiovascular peptides [4] , and improves restore endothelial function [8] , cardiorespiratory fitness (CRF) [9] , cardiac function, and clinical progression and survival in patients with HF [4] , [8] , [9] . Data has been conflicting regarding the impacts of exercise interventions and the inflammaging process in HF, with some studies reporting that aerobic [10] , [11] , resistance [12] and concurrent [13] , [14] interventions reduced inflammatory cytokines in patients with HF, whereas other studies did not report any significant changes [5] , [15] , [16] , [17] .…”

Section: Introductionmentioning

confidence: 99%

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The impacts of exercise interventions on inflammaging markers in overweight/obesity patients with heart failure: A systematic review and meta-analysis of randomized controlled trials

Malandish

Gulati

2023

IJC Heart & Vasculature

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The role of exercise training on cardiovascular peptides in patients with heart failure: A systematic review and meta-analysis

Cited by 6 publications

References 59 publications

Lifestyle Modification in Heart Failure Management: Are We Using Evidence-Based Recommendations in Real World Practice?

Lifestyle Modification in Heart Failure Management: Are We Using Evidence-Based Recommendations in Real World Practice?

The Related Metabolic Diseases and Treatments of Obesity

The impacts of exercise interventions on inflammaging markers in overweight/obesity patients with heart failure: A systematic review and meta-analysis of randomized controlled trials

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