The role of exosomal non‐coding<scp>RNAs</scp>in aging‐related diseases

Shakouri, Seyed Kazem; Dolatkhah, Neda; Yousefi, Mehdi; Niaragh, Farhad Jadidi; Sanaie, Sarvin

doi:10.1002/biof.1715

Cited by 14 publications

(5 citation statements)

References 170 publications

(152 reference statements)

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“…Interestingly, the exosome function most likely depends on the biological materials they encapsulate[ 23 , 24 ]. Mounting evidence suggests that exosomal ncRNAs (miRNA, lncRNA, and circRNA) are actively involved in the initiation and progression of various diseases by regulating cellular proliferation, differentiation, angiogenesis, and immune response[ 25 - 27 ].…”

Section: Discussionmentioning

confidence: 99%

Exosome-mediated transfer of circRNA563 promoting hepatocellular carcinoma by targeting the microRNA148a-3p/metal-regulatory transcription factor-1 pathway

Lyu,

Li,

Yang

et al. 2023

World J Gastroenterol

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BACKGROUND Mesenchymal stem cells (MSCs) exert anti-oncogenic effects via exosomes containing non-coding RNA (ncRNA), which play important roles in tumor biology. Our preliminary study identified the interaction of the ncRNA hsa_circ_0000563 (circ563) and the circ563-associated miR-148a-3p in exosomes, as miR-148a-3p and its target metal-regulatory transcription factor-1 (MTF-1) are implicated in hepatocellular carcinoma (HCC) progression. AIM To identify the clinical significance, functional implications, and mechanisms of circ563 in HCC. METHODS The expression levels of miR-148a-3p and MTF-1 in exosomes derived from MSC and HCC cells were compared, and their effects on HCC cells were assessed. Using a dual-luciferase reporter assay, miR-148a-3p was identified as an associated microRNA of circ563, whose role in HCC regulation was assessed in vitro and in vivo . RESULTS The silencing of circ563 blocked the HCC cell proliferation and invasion and induced apoptosis. Co-culturing of HCC cells with MSC-derived exosomes following circ563 overexpression promoted cell proliferation and metastasis and elicited changes in miR-148a-3p and MTF-1 expression. The tumor-promoting effects of circ563 were partially suppressed by miR-148a-3p overexpression or MTF-1 depletion. Xenograft experiments performed in nude mice confirmed that circ563-enriched exosomes facilitated tumor growth by upregulating the expression of MTF-1. In HCC tissues, circ563 expression was negatively correlated with miR-148a-3p expression but positively correlated with MTF-1 levels. CONCLUSION MSCs may exhibit anti-HCC activity through the exosomal circ563/miR-148a-3p/MTF-1 pathway, while exosomes can transmit circ563 to promote oncogenic behavior by competitively binding to miR-148a-3p to activate MTF-1.

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Section: Discussionmentioning

confidence: 99%

Exosome-mediated transfer of circRNA563 promoting hepatocellular carcinoma by targeting the microRNA148a-3p/metal-regulatory transcription factor-1 pathway

Lyu,

Li,

Yang

et al. 2023

World J Gastroenterol

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“…The BBB protects the brain from many types of diseases but also makes it difficult to create a drug treatment that targets the specific regions in brain (Dong, 2018 ). Because of the biocompatibility of exosomes and the singular function of ncRNAs, scientists in mounting numbers have been exploring exosomal ncRNAs as a promising strategy for CNS disease therapy (Li et al, 2018 ; Iranifar et al, 2019 ; Xia et al, 2019 ; Wu and Kuo, 2020 ; Dolati et al, 2021 ; Mattingly et al, 2021 ; Figure 3 ).…”

Section: Exosomal Ncrna As a Potential Therapeutic Strategy For Cns D...mentioning

confidence: 99%

Exosomal noncoding RNAs in central nervous system diseases: biological functions and potential clinical applications

Wang

Wen

et al. 2022

Front. Mol. Neurosci.

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Central nervous system (CNS) disease is a general term for a series of complex and diverse diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), CNS tumors, stroke, epilepsy, and amyotrophic lateral sclerosis (ALS). Interneuron and neuron-glia cells communicate with each other through their homeostatic microenvironment. Exosomes in the microenvironment have crucial impacts on interneuron and neuron-glia cells by transferring their contents, such as proteins, lipids, and ncRNAs, constituting a novel form of cell-to-cell interaction and communication. Exosomal noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), circular RNAs (circRNAs), and PIWI-interacting RNAs (piRNAs), regulate physiological functions and maintain CNS homeostasis. Exosomes are regarded as extracellular messengers that transfer ncRNAs between neurons and body fluids due to their ability to cross the blood-brain barrier. This review aims to summarize the current understanding of exosomal ncRNAs in CNS diseases, including prospective diagnostic biomarkers, pathological regulators, therapeutic strategies and clinical applications. We also provide an all-sided discussion of the comparison with some similar CNS diseases and the main limitations and challenges for exosomal ncRNAs in clinical applications.

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“…Exosomes takes part in various biological processes and establish intracellular communication among cells, which is essential in diverse diseases such as tumorigenesis, immunological diseases and neurodegenerative diseases hence, exosomes makes up an important cellular component (Kalluri & LeBleu, 2020). The miRNAs can be packed in exosomes and takes place in PD, before the transport of exosomes, the miRNAs should be guided by EXOmotifs to be sorted into exosomes were sorting happens in six potential mechanisms (Dolati et al, 2021; D. Li, Li, et al, 2018). MiRNA binding and sorting in exosomes are regulated by the proteins heterogeneous nuclear ribonucleoprotein (hnRNPA2B1) and synaptotagmin‐binding cytoplasmic RNA‐interacting protein (SYNCRIP) (Santangelo et al, 2016; Villarroya‐Beltri et al, 2013).…”

Section: Exosomal Mirna Driven Pathogenicity In Pdmentioning

confidence: 99%

miRNA in Parkinson's disease: From pathogenesis to theranostic approaches

Elangovan

Venkatesan

Selvaraj

et al. 2022

Journal Cellular Physiology

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Parkinson's disease (PD) is an age associated neurological disorder which is specified by cardinal motor symptoms such as tremor, stiffness, bradykinesia, postural instability, and non‐motor symptoms. Dopaminergic neurons degradation in substantia nigra region and aggregation of αSyn are the classic signs of molecular defects noticed in PD pathogenesis. The discovery of microRNAs (miRNA) predicted to have a pivotal part in various processes regarding regularizing the cellular functions. Studies on dysregulation of miRNA in PD pathogenesis has recently gained the concern where our review unravels the role of miRNA expression in PD and its necessity in clinical validation for therapeutic development in PD. Here, we discussed how miRNA associated with ageing process in PD through molecular mechanistic approach of miRNAs on sirtuins, tumor necrosis factor‐alpha and interleukin‐6, dopamine loss, oxidative stress and autophagic dysregulation. Further we have also conferred the expression of miRNAs affected by SNCA gene expression, neuronal differentiation and its therapeutic potential with PD. In conclusion, we suggest more rigorous studies should be conducted on understanding the mechanisms and functions of miRNA in PD which will eventually lead to discovery of novel and promising therapeutics for PD.

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The role of exosomal non‐codingRNAsin aging‐related diseases

Cited by 14 publications

References 170 publications

Exosome-mediated transfer of circRNA563 promoting hepatocellular carcinoma by targeting the microRNA148a-3p/metal-regulatory transcription factor-1 pathway

Exosome-mediated transfer of circRNA563 promoting hepatocellular carcinoma by targeting the microRNA148a-3p/metal-regulatory transcription factor-1 pathway

Exosomal noncoding RNAs in central nervous system diseases: biological functions and potential clinical applications

miRNA in Parkinson's disease: From pathogenesis to theranostic approaches

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