The Role of Extracellular Vesicles in SARS-CoV-2-Induced Acute Kidney Injury: An Overview

Bernal, Carter; How-Volkman, Christiane; Spencer, Madison; El-Shamy, Ahmed; Mohieldin, Ashraf M.

doi:10.3390/life14020163

Cited by 3 publications

(1 citation statement)

References 118 publications

(136 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These EVs can transfer viral components like CD9 and ACE2, aiding in virus docking and entry into cells. Studies have shown that EVs can carry many virus particles, contributing to the transmission of SARS-CoV-2 [73][74][75]. Furthermore, EVs released from SARS-CoV-2infected cells are involved in reprogramming the proteome and transcriptome of host cells, promoting the viral life cycle, and sustaining infection.…”

Section: Vaccination With Nanoparticles (Lnp) and Extracellular Vesic...mentioning

confidence: 99%

Understanding the Molecular Actions of Spike Glycoprotein in SARS-CoV-2 and Issues of a Novel Therapeutic Strategy for the COVID-19 Vaccine

Matsuzaka,

Yashiro

2024

BioMedInformatics

View full text Add to dashboard Cite

In vaccine development, many use the spike protein (S protein), which has multiple “spike-like” structures protruding from the spherical structure of the coronavirus, as an antigen. However, there are concerns about its effectiveness and toxicity. When S protein is used in a vaccine, its ability to attack viruses may be weak, and its effectiveness in eliciting immunity will only last for a short period of time. Moreover, it may cause “antibody-dependent immune enhancement”, which can enhance infections. In addition, the three-dimensional (3D) structure of epitopes is essential for functional analysis and structure-based vaccine design. Additionally, during viral infection, large amounts of extracellular vesicles (EVs) are secreted from infected cells, which function as a communication network between cells and coordinate the response to infection. Under conditions where SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) molecular vaccination produces overwhelming SARS-CoV-2 spike glycoprotein, a significant proportion of the overproduced intracellular spike glycoprotein is transported via EVs. Therefore, it will be important to understand the infection mechanisms of SARA-CoV-2 via EV-dependent and EV-independent uptake into cells and to model the infection processes based on 3D structural features at interaction sites.

show abstract

Section: Vaccination With Nanoparticles (Lnp) and Extracellular Vesic...mentioning

confidence: 99%

Understanding the Molecular Actions of Spike Glycoprotein in SARS-CoV-2 and Issues of a Novel Therapeutic Strategy for the COVID-19 Vaccine

Matsuzaka,

Yashiro

2024

BioMedInformatics

View full text Add to dashboard Cite

show abstract

The Role of Dental-derived Stem Cell-based Therapy and Their Derived Extracellular Vesicles in Post-COVID-19 Syndrome-induced Tissue Damage

Rostami,

Farahani,

Esmaelian

et al. 2024

Stem Cell Rev and Rep

View full text Add to dashboard Cite

Circulating extracellular vesicles from severe COVID-19 patients induce lung inflammation

Qian,

Zang,

Zhang

et al. 2024

mSphere

View full text Add to dashboard Cite

Circulating extracellular vesicles (EVs) have been associated with the development of COVID-19 due to their roles in viral infection, inflammatory response, and thrombosis. However, the direct induction of lung inflammation by circulating EVs from severe COVID-19 patients remains unknown. EVs were extracted from the plasma of severe COVID-19 patients admitted to intensive care and healthy controls. To study the effect of COVID-19 EVs on lung inflammation, mice were intratracheally instilled with EVs. To examine the proinflammatory effects of EVs in vitro , bone marrow-derived macrophages were treated with EVs. COVID-19 but not control EVs triggered lung inflammation, as assessed by total protein level, total cell count, neutrophil count, and levels of proinflammatory cytokines in the bronchoalveolar lavage. COVID-19 EVs also promoted M1 polarization of alveolar macrophages in vivo . Treatment of bone marrow-derived macrophages with COVID-19 EVs enhanced the M1 phenotype and augmented the production of IL-1β, IL-6, and TNF-α. In summary, circulating EVs from severe COVID-19 patients induce lung inflammation in mice. EVs could become a potential therapeutic target for alleviating lung injury in COVID-19. IMPORTANCE Extracellular vesicles (EVs) have been reported to facilitate cytokine storm, coagulation, vascular dysfunction, and the spread of the virus in COVID-19. The direct role of circulating EVs from severe COVID-19 patients in lung injury remains unrecognized. Our study demonstrated that plasma EVs obtained from severe COVID-19 patients induced lung inflammation and polarization of alveolar macrophages in vivo . In vitro experiments also revealed the proinflammatory effects of COVID-19 EVs. The present study sheds fresh insight into the mechanisms of COVID-19-induced lung injury, highlighting EVs as a potential therapeutic target in combating the disease.

show abstract

The Role of Extracellular Vesicles in SARS-CoV-2-Induced Acute Kidney Injury: An Overview

Cited by 3 publications

References 118 publications

Understanding the Molecular Actions of Spike Glycoprotein in SARS-CoV-2 and Issues of a Novel Therapeutic Strategy for the COVID-19 Vaccine

Understanding the Molecular Actions of Spike Glycoprotein in SARS-CoV-2 and Issues of a Novel Therapeutic Strategy for the COVID-19 Vaccine

The Role of Dental-derived Stem Cell-based Therapy and Their Derived Extracellular Vesicles in Post-COVID-19 Syndrome-induced Tissue Damage

Circulating extracellular vesicles from severe COVID-19 patients induce lung inflammation

Contact Info

Product

Resources

About