The Role of Extracorporeal Shock Wave Therapy and Manual Lymphatic Drainage in Chronic Ulcers Treatment

Saggini, Raoul; Saggini, Andrea; Sm, Carmignano; Palermo, Tonya M.; Barassi, G; Mg, Onesti; Rg, Bellomo; Scuderi, N

doi:10.15344/2394-1502/2016/119

Cited by 1 publication

(2 citation statements)

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“…Meanwhile, the oxygen supply from Nano-PFC could neutralize the hypoxic microenvironment due to the vascular disruption and the oxygen consumption by inflammatory and stromal cells within the wound. And rESW treatment might reduce oxidative stress, compared to HBOT, which overcame the drawbacks of HBOT [35,36]. At present, although many adjunctive therapies have been applied for the healing of DFUs, just as previously discussed [5][6][7]12], the clinic treatment of DFUs remained as an enormous challenge due to the multifactors of that.…”

Section: Nano-pfc Plus Resw Treatment Accelerated Diabeticmentioning

confidence: 99%

“…Thus, the rESW is a candidate trigger source to enhance inclusion release inside an NDDS. Furthermore, ESW therapy has been reported to distinctly improve and promote the healing of DFUs by mainly enhancing blood microcirculation and tissue regeneration and reducing oxidative stress [35,36]. However, the corresponding studies about rESWT are few.…”

Section: Introductionmentioning

confidence: 99%

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Improved Healing of Diabetic Foot Ulcer upon Oxygenation Therapeutics through Oxygen-Loading Nanoperfluorocarbon Triggered by Radial Extracorporeal Shock Wave

Wang

Yin

Han

et al. 2019

Oxidative Medicine and Cellular Longevity

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Diabetic foot ulcers (DFUs), the most serious complication of diabetes mellitus, can induce high morbidity, the need to amputate lower extremities, and even death. Although many adjunctive strategies have been applied for the treatment of DFUs, the low treatment efficiency, potential side effects, and high cost are still huge challenges. Recently, nanomaterial-based drug delivery systems (NDDSs) have achieved targeted drug delivery and controlled drug release, offering great promises in various therapeutics for diverse disorders. Additionally, the radial extracorporeal shock wave (rESW) has been shown to function as a robust trigger source for the NDDS to release its contents, as the rESW harbors a potent capability in generating pressure waves and in creating the cavitation effect. Here, we explored the performance of oxygen-loaded nanoperfluorocarbon (Nano-PFC) combined with the rESW as a treatment for DFUs. Prior to in vivo assessment, we first demonstrated the high oxygen affinity in vitro and great biocompatibility of Nano-PFC. Moreover, the rESW-responsive oxygen release behavior from oxygen-saturated Nano-PFC was also successfully verified in vitro and in vivo. Importantly, the wound healing of DFUs was significantly accelerated due to improved blood microcirculation, which was a result of rESW therapy (rESWT), and the targeted release of oxygen into the wound from oxygen-loaded Nano-PFC, which was triggered by the rESW. Collectively, the oxygen-saturated Nano-PFC and rESW provide a completely new approach to treat DFUs, and this study highlights the advantages of combining nanotechnology with rESW in therapeutics.

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