The role of FASL, BCL-2 and BAX polymorphisms in brazilian patients with prostate cancer and benign prostatic hyperplasia

Lawisch, Gabriela Kniphoff da Silva; Biolchi, Vanderlei; Kaufmann, Gabriela; Nicolai, Gabriela; Capitaneo, Eduarda; Rosembach, Thais Regina; Zang, Janaina; Brum, Ilma Simoni; Chies, Jose Artur Bogo

doi:10.1007/s11033-022-07805-3

Cited by 3 publications

(3 citation statements)

References 32 publications

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“…Finally, the identification of PCA susceptibility genetic markers, as well as genetic markers associated with clinical outcomes, is another important field of research. In our laboratory, research has been carried out with important contributions in the field of biomarkers for prostate cancer and benign prostatic hyperplasia, such as associations with polymorphisms in the apoptosis genes BCL-2 , FASL and BAX ( da Silva Lawisch et al, 2022 ), HLA-G variant ( Zambra et al, 2016 ) and polymorphisms in the CCR2 and CCR5 genes ( Zambra et al ., 2013 ).…”

Section: Resultsmentioning

confidence: 99%

Prostate tumor markers: diagnosis, prognosis and management

Lawisch,

Dexheimer,

Biolchi

et al. 2023

Genet. Mol. Biol.

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Prostate cancer (PCA) is the second most common type of cancer in the world. Nevertheless, diagnosis is still based on nonspecific methods, or invasive methods which makes clinical decision and diagnosis difficult, generating risk of both underdiagnosis and overdiagnosis. Given the high prevalence, morbidity and mortality of PCA, new strategies are needed for its diagnosis. A review of the literature on available biomarkers for PCA was performed, using the following terms: prostate cancer AND marker OR biomarker. The search was carried out in Pubmed, Science Direct, Web of Science and Clinical Trial. A total of 35 articles were used, and PHI (Prostate Health Index) and the 4Kscore tests were identified as the best well-established serum markers. These tests are based on the evaluation of expression levels of several molecules. For analysis of urine samples, Progensa, ExoDXProstate, and Mi Prostate Score Urine Test are available. All these tests have the potential to help diagnosis, avoiding unnecessary biopsies, but they are used only in association with digital rectal examination and PSA level data. The search for biomarkers that can help in the diagnosis and therapeutic management of PCA is still in its initial phase, requiring more efforts for an effective clinical application.

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Section: Resultsmentioning

confidence: 99%

Prostate tumor markers: diagnosis, prognosis and management

Lawisch,

Dexheimer,

Biolchi

et al. 2023

Genet. Mol. Biol.

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“…Upon activation, Bax undergoes dimerization on the mitochondrial membrane, which in turn boosts the formation of MOMP pores, thereby allowing pro-apoptotic proteins to enter the cell [ 78 ]. Conversely, proteins such as Bcl-2 and Mcl-1 restrain the formation of MOMP pores, preventing the leakage of pro-apoptotic proteins into the cytoplasm and subsequent apoptosis [ 79 ]. They exert their function by sequestering pro-apoptotic factors, such as Bax or Bak, thereby preventing MOMP [ 80 ].…”

Section: Biological Role Of Tctp In Tumorigenesis and Developmentmentioning

confidence: 99%

Biological role and expression of translationally controlled tumor protein (TCTP) in tumorigenesis and development and its potential for targeted tumor therapy

Liu,

Wang

et al. 2024

Cancer Cell Int

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Translationally controlled tumor protein (TCTP), also known as histamine-releasing factor (HRF) or fortilin, is a highly conserved protein found in various species. To date, multiple studies have demonstrated the crucial role of TCTP in a wide range of cellular pathophysiological processes, including cell proliferation and survival, cell cycle regulation, cell death, as well as cell migration and movement, all of which are major pathogenic mechanisms of tumorigenesis and development. This review aims to provide an in-depth analysis of the functional role of TCTP in tumor initiation and progression, with a particular focus on cell proliferation, cell death, and cell migration. It will highlight the expression and pathological implications of TCTP in various tumor types, summarizing the current prevailing therapeutic strategies that target TCTP.

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“…Bcl2 gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells, including lymphocytes. Constitutive expression of BCL2 is thought to be the cause of follicular lymphoma, mature T-cell lymphomas [ 27 ], prostate cancer [ 28 ], and renal cell carcinomas [ 29 ]. Most importantly for the brain death, stress activates cell survival and cell death signaling pathways that converge on mitochondria, a process that is controlled by the activities of BCL-2 proteins.…”

Section: Ex Vivo Organ Viability and Gene Expressionmentioning

confidence: 99%

Induced Coma, Death, and Organ Transplantation: A Physiologic, Genetic, and Theological Perspective

Coliță

Olaru

Coliță

et al. 2023

IJMS

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In the clinic, the death certificate is issued if brain electrical activity is no longer detectable. However, recent research has shown that in model organisms and humans, gene activity continues for at least 96 h postmortem. The discovery that many genes are still working up to 48 h after death questions our definition of death and has implications for organ transplants and forensics. If genes can be active up to 48 h after death, is the person technically still alive at that point? We discovered a very interesting parallel between genes that were upregulated in the brain after death and genes upregulated in the brains that were subjected to medically-induced coma, including transcripts involved in neurotransmission, proteasomal degradation, apoptosis, inflammation, and most interestingly, cancer. Since these genes are involved in cellular proliferation, their activation after death could represent the cellular reaction to escape mortality and raises the question of organ viability and genetics used for transplantation after death. One factor limiting the organ availability for transplantation is religious belief. However, more recently, organ donation for the benefit of humans in need has been seen as “posthumous giving of organs and tissues can be a manifestation of love spreading also to the other side of death”.

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The role of FASL, BCL-2 and BAX polymorphisms in brazilian patients with prostate cancer and benign prostatic hyperplasia

Cited by 3 publications

References 32 publications

Prostate tumor markers: diagnosis, prognosis and management

Prostate tumor markers: diagnosis, prognosis and management

Biological role and expression of translationally controlled tumor protein (TCTP) in tumorigenesis and development and its potential for targeted tumor therapy

Induced Coma, Death, and Organ Transplantation: A Physiologic, Genetic, and Theological Perspective

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