The role of feed regulating peptides on weight loss in patients with pulmonary tuberculosis

Yurt, Sibel; Erman, Hayriye; Korkmaz, Gülcan Güntaş; Koşar, Altuğ; Uysal, Pelin; Gelışgen, Remise; Şimşek, Gönül; Uzun, Hafize

doi:10.1016/j.clinbiochem.2012.09.008

Cited by 18 publications

(25 citation statements)

References 27 publications

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“…Herlina and his colleagues have found that the PTB patients had lower body mass index and downregulated circulating leptin levels as compared to the healthy adults, and indicated that down-regulated leptin levels due to the loss of body weight may lead to the reduction of leptin production, which may be correlated with the progression of PTB (5). Yurt et al have also proved that PTB patients were related to lower leptin levels and also implied that a catabolic/anabolic imbalance may be associated with the down-regulated leptin levels which may induce the development of PTB (27). In this study, we propose that the down-regulated serum leptin levels may be connected with the development of PTB, which corroborates with the results of previous studies on adult PTB development.…”

Section: Discussionsupporting

confidence: 91%

“…Mainly produced by white adipose tissue, serum leptin levels were significantly associated with body fat mass as well as adipocyte size, and serum leptin levels were changed by nutritional status of individuals, decreasing with starvation and increasing with obesity (35). Further, downregulated serum leptin levels might be one underlying mechanism of the loss of body weight which is induced by acute inflammatory conditions, and also the prolonged inflammation may further restrain the production of leptin (27). As we all known, patients with PTB often suffer from severe weight loss, probably caused by the production of inflammatory mediators in PTB development (26).…”

Section: Discussionmentioning

confidence: 99%

“…Of these articles, 31 were excluded based on the titles and key words; the full text of 36 was obtained and another 24 papers were eliminated after reviewing the abstract and full text. Eventually, 12 studies met our inclusion criteria were enrolled in this meta-analysis (5,18,(20)(21)(22)(26)(27)(28)(29)(30)(31)(32). These 12 case-control studies included 332 PTB patients and 292 healthy controls.…”

Section: Baseline Characteristics Of Included Studiesmentioning

confidence: 99%

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Association of serum leptin levels and pulmonary tuberculosis: a meta-analysis

Ye¹,

Bian²

2018

J. Thorac. Dis.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Baseline Characteristics Of Included Studiesmentioning

confidence: 99%

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Association of serum leptin levels and pulmonary tuberculosis: a meta-analysis

Ye¹,

Bian²

2018

J. Thorac. Dis.

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“…Santucci et al found a positive correlation between leptin concentrations and BMI (11), while another study found no correlation between these two parameters (27). Animal experiments suggest that leptin contributes to protection against M.tb by inducing Th1 cytokine responses (28).…”

Section: Discussionmentioning

confidence: 97%

“…Some have suggested that leptin does not form part of the pro-inflammatory response (30) and in agreement with this, leptin did not correlate with any of the inflammatory markers investigated in this study. Ghrelin, which is produced by the stomach and acts as an orexigenic factor (31), is present at higher concentrations in TB patients and the increase in ghrelin concentrations could act as a compensatory mechanism to weight loss (27). Ghrelin can furthermore downregulate pro-inflammatory cytokine responses (32, 33).…”

Section: Discussionmentioning

confidence: 99%

Changes in Host Immune–Endocrine Relationships during Tuberculosis Treatment in Patients with Cured and Failed Treatment Outcomes

et al. 2017

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A bidirectional communication between the immune and endocrine systems exists and facilitates optimum responses in the host during infections. This is in part achieved through changes in secretion patterns of hypothalamic hormones induced by inflammatory cytokines. The aim of this study was to elucidate the immune–endocrine alterations during tuberculosis (TB) treatment in patients with cured and failed TB treatment outcomes. Blood samples were collected from 27 cured and 10 failed patients and hormone as well as cytokine concentrations quantified at baseline, week 4, and month 6 of TB treatment. Hormone profiles of the two treatment outcome groups were different from each other prior to as well as during TB treatment. Treatment response effects were observed for cortisol, estradiol, T3, T4 ghrelin, leptin, amylin, adiponectin, and dehydroepiandrosterone (DHEA). Trends suggest that T4, amylin, and DHEA concentrations were different between treatment outcomes, although these did not reach statistical significance. Relationships between endocrine and inflammatory markers and the biological pathways involved differed between cured and failed treatment patients. These results highlight the complex interaction between the endocrine and immune system during active TB disease and throughout treatment and suggest that endocrine markers in conjunction with inflammatory markers may be useful in predicting unfavorable treatment outcomes.

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Profiles of Volatile Biomarkers Detect Tuberculosis from Skin

et al. 2021

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Tuberculosis (TB) is an infectious disease that threatens >10 million people annually. Despite advances in TB diagnostics, patients continue to receive an insufficient diagnosis as TB symptoms are not specific. Many existing biodiagnostic tests are slow, have low clinical performance, and can be unsuitable for resource‐limited settings. According to the World Health Organization (WHO), a rapid, sputum‐free, and cost‐effective triage test for real‐time detection of TB is urgently needed. This article reports on a new diagnostic pathway enabling a noninvasive, fast, and highly accurate way of detecting TB. The approach relies on TB‐specific volatile organic compounds (VOCs) that are detected and quantified from the skin headspace. A specifically designed nanomaterial‐based sensors array translates these findings into a point‐of‐care diagnosis by discriminating between active pulmonary TB patients and controls with sensitivity above 90%. This fulfills the WHO's triage test requirements and poses the potential to become a TB triage test.

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The role of feed regulating peptides on weight loss in patients with pulmonary tuberculosis

Cited by 18 publications

References 27 publications

Association of serum leptin levels and pulmonary tuberculosis: a meta-analysis

Association of serum leptin levels and pulmonary tuberculosis: a meta-analysis

Changes in Host Immune–Endocrine Relationships during Tuberculosis Treatment in Patients with Cured and Failed Treatment Outcomes

Profiles of Volatile Biomarkers Detect Tuberculosis from Skin

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