The role of fibroblasts in the remodeling of periodontal ligament during physiologic tooth movement

Cate, A. R. Ten; Deporter, Douglas; Freeman, Eric

doi:10.1016/0002-9416(76)90194-9

Cited by 135 publications

(24 citation statements)

References 17 publications

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“…Orthodontic treatments frequently lead to post-treatment relapse, particularly rotational relapse (Little, 1990). In this context, we note that the collagen fibers of the periodontium are remodeled by fibroblasts in response to applied force (Ten Cate et al, 1976). Following significant tooth rotation, the re-orientation of the collagen fibers in the gingival and transseptal region is histologically (Reitan and Skillen, 1940) and clinically (Edwards, 1970) slower than that of periodontal ligament collagen fibers, perhaps reflecting the much slower collagen turnover that is exhibited by gingiva (Sodek, 1977).…”

Section: (5) Orthodontic Tooth Movement and Treatment Relapsementioning

confidence: 93%

Is Fibroblast Heterogeneity Relevant To the Health, Diseases, and Treatments of Periodontal Tissues?

Lekic

Pender

McCulloch

1997

Critical Reviews in Oral Biology & Medicine

122

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There are wide variations of gene expression and strikingly different responses to extracellular signals among different fibroblast populations. This has prompted a large number of in vitro studies which suggest that fibroblasts are not homogeneous but instead comprise multiple subpopulations with extensive site-to-site and intra-site variations. Conceivably, either fibroblasts are not all created equal, or, alternatively, discrete subpopulations may emerge in development, inflammatory lesions, or wound healing. While the heterogeneous nature of cultured fibroblasts has been known for some time, are these variations relevant to our understanding of the biology of oral tissues, their involvement in disease, and their response to therapy? Since fibroblasts are the predominant cell type in soft connective tissue matrices, the regulation of their proliferative, synthetic, and degradative behavior is likely to be important in tissue physiology and pathology. In this review, we use the current literature to assess whether fibroblast subpopulations really make a difference in the health and disease of periodontal tissues. We address the following questions: (1) Is fibroblast heterogeneity a real in vivo phenomenon? (2) How can we advance our knowledge of phenotypic variations and the regulation of fibroblast differentiation? (3) Could a knowledge of fibroblast heterogeneity have an impact on the development of new approaches to pathogenesis and the treatment of periodontal tissues?

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Section: (5) Orthodontic Tooth Movement and Treatment Relapsementioning

confidence: 93%

Is Fibroblast Heterogeneity Relevant To the Health, Diseases, and Treatments of Periodontal Tissues?

Lekic

Pender

McCulloch

1997

Critical Reviews in Oral Biology & Medicine

122

View full text Add to dashboard Cite

show abstract

“…The cells thought to be responsible are the fibroblasts within the periodontal ligament, which have contractile potential. An early paper by Ten Cate et al 6 discussed the role of fibroblasts in the remodelling of the periodontal ligament, citing various studies indicating the role of fibroblasts in phagocytosis during re-modelling, increased fibroblastic activity during eruption and the distribution of fibroblasts within the periodontal ligament as indicators that fibroblasts play a key role in physiologic tooth movement. Although informative, this study consisted of histological observations, and did not provide sufficient data on the origins of the tissues studied (ie species, age, whether eruption was occurring) to enable the reader to accurately extrapolate the findings to eruptive tooth movement in humans.…”

Section: Periodontal Ligamentmentioning

confidence: 99%

Eruptive tooth movement — the current state of knowledge

Craddock

Youngson

2004

Br Dent J

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How the dentition erupts, and what controls it, is fundamental to almost all aspects of clinical dentistry, yet the mechanisms behind this have not yet been fully elucidated. When the process continues into space that has been created through toothwear or tooth loss, problems in placing restorations can be encountered. This review examines the possible mechanisms of tooth eruption. Differences between processes in animals and humans are highlighted. The limitations of conclusions drawn from animal studies are then discussed with reference to human dental conditions. The differing forms of overeruption in humans are described and the treatment options for overerupted teeth, including prevention of the situation arising, are provided with a discussion of the quality of the evidence base behind these.

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“…Wound contraction occurs over a period of few weeks and months. [18] The tissue gradually becomes normal, healing is complete and no scar is observed. The three month post operative photograph, [Figure 4d] represents this stage.…”

Section: Discussionmentioning

confidence: 99%

Perio-esthetic surgery: Using LPF with frenectomy for prevention of scar

Chaubey¹,

Arora²,

Thakur³

et al. 2011

J Indian Soc Periodontol

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An aberrant frenum is postulated to create functional and aesthetic problems. Archer's ‘classical frenectomy’ is an extensive procedure including the excision of fibers, interdental papilla, and exposure of alveolar bone up to the palatine papilla. The resultant delayed healing, loss of interdental papilla, and abnormal scar led towards the conservative approaches like Edward's frenectomy, frenum relocation by Z-plasty and free gingival graft; with their technical and aesthetic limitations. A better approach to make a primary closure in midline and to avoid anesthetic scar by creating a zone of attached gingiva, frenectomy is assisted with lateral pedicle graft. The interdental papilla is left surgically undisturbed and healing takes place by primary intention. Miller, in his study on 27 subjects, suggested that the newly created zone of attached gingiva might have bracing effect inhibiting reopening of diastema. A case series of this technique with its distinct advantages is presented.

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The role of fibroblasts in the remodeling of periodontal ligament during physiologic tooth movement

Cited by 135 publications

References 17 publications

Is Fibroblast Heterogeneity Relevant To the Health, Diseases, and Treatments of Periodontal Tissues?

Is Fibroblast Heterogeneity Relevant To the Health, Diseases, and Treatments of Periodontal Tissues?

Eruptive tooth movement — the current state of knowledge

Perio-esthetic surgery: Using LPF with frenectomy for prevention of scar

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